Modern genetic markers of chronic heart failure

Abstract

Due to the rapid spread and large coverage, chronic heart failure (CHF) is reaching the state of a pandemic of the 21st century. Among elderly patients, HF is the main reason for referral to hospital. Half of patients with this pathology die within 5 years after diagnosis. Currently, the diagnosis of CHF is gaining momentum due to the importance of this disease. There are more and more studies and works that prove the high sensitivity of cardiac markers for diagnosing CHF. There are many genes that can participate in the formation of a hereditary predisposition, both independently and through interaction with each other. This literature review was carried out in order to identify genetic markers for diagnosing CHF. The results of studies that can be used to analyze the effect of polymorphism of the genes coding angiotensinogen, angiotensin-converting enzyme, β2-adrenoreceptor, nitric oxide synthase, aldosterone synthase are presented. An in-depth study of molecular genetic markers, as well as determining their significance in the development of heart failure, is an urgent problem of modern medicine, the solution of which will make it possible to carry out effective prevention of cardiovascular complications, optimize treatment and improve the prognosis of patients. Information on the topic from publications based on the PubMed, eLibrary databases was used.