Modern evaluation of left ventricular diastolic function using Doppler echocardiography

Gabriel, Ruvin; Klein, Allan L.

doi:10.1007/s11886-009-0033-9

Cited by 27 publications

(36 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the hope for new technologies and enhancements of current tools, it is still important to use the mainstay measures of left atrial size and pulmonary pressure as these basic parameters are frequently invaluable in making the distinction between normal and abnormal diastolic function. Left atrial enlargement and pulmonary hypertension are unlikely in the setting of truly normal diastolic function [27,[32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

Increased mortality in patients with conflicting diastolic parameters

Bahrainy

Gill

2011

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

The aim of this study was to describe the clinical characteristics and mortality of patients with conflicting diastolic function during follow-up. Up to 30% of patients have conflicting diastolic function by echo Doppler and therefore cannot be classified into a distinct diastolic dysfunction category of stage 1, 2 or 3. Using our established echocardiography data base, we studied a cohort of 250 subjects with conflicting diastolic function. Each individual was compared to two controls with normal diastolic and systolic function. The pre-specified goal of the analysis was a 6-year follow-up. Patients with conflicting diastolic function were more likely to have diabetes, hypertension, and established coronary artery disease. The Cox proportional hazards model determined that the risk of death was significantly higher for conflicting patients compared to patients with normal diastolic parameters (HR: 1.83; 95% CI: 1.32-2.53), P < 0.001. After adjustment for covariates, the risk of death remained elevated for the conflicting group (HR: 1.56; 95% CI: 1.11-2.18), P = 0.009. Conflicting diastolic dysfunction is associated with an increased risk of death compared to individuals with normal function. In conclusion, this emphasizes the need to attain a more precise characterization and categorization for patients with diastolic dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased mortality in patients with conflicting diastolic parameters

Bahrainy

Gill

2011

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

show abstract

“…Pulsed-wave Doppler tissue imaging was performed using the same machine and was used to measure the mitral annulus velocity during diastole in the assessment of diastolic function. The E/E 0 value (the quotient of E and the average of the diastolic annular velocity (E 0 )) was calculated as a preload independent index used for estimating the LV filling pressure [19].…”

Section: Echocardiography Measurementsmentioning

confidence: 99%

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Porcar-Almela

Codoñer‐Franch

Tuzón

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

“…This metric has since become the most broadly used clinical measure of diastolic function. [25][26][27] Other measures of transmitral flow, including the E-wave deceleration time and velocity-time integral of the E and A wave, have also been used to describe LV diastolic function. However, there are drawbacks to the use of the transmitral inflow alone in the assessment of diastolic function, 28 and particularly in the description of diastolic ventricular filling pertaining to the atria and the development of AF.…”

Section: Measurement Of Ventricular Diastolic Functionmentioning

confidence: 99%

Diastolic Dysfunction and Risk of Atrial Fibrillation

2012

View full text Add to dashboard Cite

A trial fibrillation (AF) is the most common sustained arrhythmia, and its prevalence in the population is increasing. 1 Diastolic dysfunction shares many common risk factors with AF, including age, hypertension, 2-5 obesity, 6,7 and diabetes. 8,9 Like AF, diastolic dysfunction increases with age, 10 and patients given the diagnosis of diastolic dysfunction are more likely to have AF at the time. 11 Diastolic dysfunction has significant pathological effects on atrial structure and function, many of which are proarrhythmic. However, much remains to be learned about the specific mechanisms through which diastolic dysfunction ultimately promotes AF.Previous reviews have examined the broad association of diastolic dysfunction and AF. 12 In this review, we attempt to examine this association on a mechanistic level. We begin with a basic review of the physiology of diastolic function, with particular attention to the complex interaction between the atrium and the ventricle during diastole. We then provide an overview of some of the most common clinical methods to quantify diastolic function and highlight the strengths and weaknesses of these methods with regard to providing an accurate picture of this physiology. We describe how these methods are applied to diagnose diastolic dysfunction, including the development of a widely adopted classification scheme of diastolic dysfunction. We then review the limited clinical data available connecting diastolic dysfunction with the risk of incident, nonvalvular AF, with a focus on studies examining diastolic dysfunction in populations without structural heart disease-ie, with preserved systolic function in the absence of hypertrophic cardiomyopathic disease or congenital heart disease. Finally, we attempt to reconcile the results of these clinical studies with experimental data in both human, animal, and cellular models, to create a mechanistic link between diastolic dysfunction and pathological changes that increase the likelihood of AF. Atrial and Ventricular Diastolic DynamicsA number of excellent resources are available for more detailed review of the dynamics of ventricular diastole, including invasive 13 and noninvasive 14 -17 descriptions. Ventricular diastole is the period of the cardiac cycle that begins with the closure of the aortic valve and ends with mitral valve closure, during which the ventricle is filling with blood. It can be further divided into 4 sequential components: (1) isovolumic relaxation, (2) early rapid filling, (3) diastasis, and (4) atrial systole (late filling). Dynamically, none of the components is completely independent of each other, or the systolic function of the heart, and changes in one can influence the others in predictable and unpredictable ways.Essentially, there are 2 characteristics of ventricular function that contribute to diastolic function: relaxation (lusitropy) and compliance. Relaxation refers to the process by which the ventricular pressure drops after contraction to a level below that of the atrium, causing blood to flow dow...

show abstract

Modern evaluation of left ventricular diastolic function using Doppler echocardiography

Cited by 27 publications

References 47 publications

Increased mortality in patients with conflicting diastolic parameters

Increased mortality in patients with conflicting diastolic parameters

Left ventricular diastolic function and cardiometabolic factors in obese normotensive children

Diastolic Dysfunction and Risk of Atrial Fibrillation

Contact Info

Product

Resources

About