Modern cell technologies in the treatment of patients with tympanic membrane injury inflicted by mine explosion

Abstract

We evaluated the efficiency of transplantation of cultured human allofibroblasts onto tympanic membrane damaged by mine explosion in combination with Tampograss dressing (Paul Hartman). Transplantation of cultured human allofibroblasts was effective in 100% cases. Application of the film with fibroblasts onto perforation occupying from 1/4 to 1/2 of the tympanic membrane was more effective by 15% (by 59% in subtotal perforation) than tympanoplasty with amnion membrane. The mean duration of tympanic membrane restoration after spontaneous healing and amnionoplasty is virtually the same, while transplantation of allofibroblasts accelerated the process in comparison with other groups in perforation of any size; in subtotal defect the duration of tympanic membrane restoration was shorter by 14 +/- 1 days.

Application of amniotic membranes in reconstructive surgery of internal organs—A systematic review and meta‐analysis

“…In the case report on bronchial stump closure, no significant change in fistula size was reported after AM application (Kumar et al., 2015 ). The closure rate in the other clinical studies varied between 44% and 100% (Ambrus, 1967 ; Catalano & Conticello, 1968 ; Eichberg et al., 2018 , 2019 ; Kakabadze et al., 2016 ; Marton et al., 2018 ; Razzaghi et al., 2020 ; Rohleder et al., 2013 ; Schrimpf, 1954 ; Tahami et al., 2020 ; Tomita et al., 2012 ; Ts'ao, 1960 ; Tumanov et al., 2006 ; Turchan et al., 2018 ; Walker et al., 2018 ; Zmijewski & Pietraszek, 2005 ) (Table 3 ). In the only RCT on anal fistulas, the reduction in wound size was superior after AM application compared to the control group ( p < 0.01) (Ghahramani et al., 2017 ).…”

“…The PRISMA flowchart is shown in Figure 2. Sixty references containing 26 human studies (Ambrus, 1967; Barski et al., 2015; Catalano & Conticello, 1968; De Weerd et al., 2013, 2020; Eichberg et al., 2018, 2019; Frigerio et al., 2019; Ghahramani et al., 2017; Kakabadze et al., 2016; Kumar et al., 2015; Marton et al., 2021; Pignatti et al., 2020; Price & Price, 2016; Razzaghi et al., 2020; Rohleder et al., 2013; Schoellhammer et al., 2018; Schrimpf, 1954; Singh et al., 2011; Tahami et al., 2020; Tomita et al., 2012; Ts'ao, 1960; Tumanov et al., 2006; Turchan et al., 2018; Walker et al., 2018; Zmijewski & Pietraszek, 2005) and 36 animal studies (Barski et al., 2017; Brown et al., 2014; Demir et al., 2021; Ercin et al., 2019; Erdener et al., 1992; Ferhatoglu et al., 2019; Fishman et al., 1987; Francisco et al., 2016; Ghahramani et al., 2014; Güneş et al., 2016, 2017; Hariastawa et al., 2020; Iijima et al., 2007; Ismail, Marcos, et al., 2009; Ismail, Ramsis, et al., 2009; Kesting et al., 2008, 2010; Li et al., 2019; Liu et al., 2021; Mohajeri et al., 2014; Moslemi et al., 2016; Orman et al., 2020; Rohleder et al., 2013; Roshanravan et al., 2014; Schimidt et al., 2010; Scott et al., 2021; Scudamore et al., 1988; Senthil‐Kumar et al., 2016; Tomita et al.,…”

“…Price, 2016;Razzaghi et al, 2020;Rohleder et al, 2013;Schoellhammer et al, 2018;Schrimpf, 1954;Singh et al, 2011;Tahami et al, 2020;Tomita et al, 2012;Ts'ao, 1960;Tumanov et al, 2006;Turchan et al, 2018;Walker et al, 2018;Zmijewski & Pietraszek, 2005) and 36 animal studies(Barski et al, 2017;Brown et al, 2014;Demir et al, 2021;Ercin et al, 2019;Erdener et al, 1992;Ferhatoglu et al, 2019;Fishman et al, 1987; Francisco et al, 2016;Ghahramani et al, 2014;Güneş et al, 2016Güneş et al, , 2017Hariastawa et al, 2020;Iijima et al, 2007;Ismail, Marcos, et al, 2009;Ismail, Ramsis, et al, 2009;Kesting et al, 2008Kesting et al, , 2010Li et al, 2019;Liu et al, 2021;Mohajeri et al, 2014;Moslemi et al, 2016;Orman et al, 2020;Rohleder et al, 2013;Roshanravan et al, 2014;Schimidt et al, 2010;Scott et al, 2021;Scudamore et al, 1988;Senthil-Kumar et al, 2016;…”