Modern biomaterials: a review—bulk properties and implications of surface modifications

Roach, Paul; Eglin, David; Rohde, Kirsty; Perry, Carole C.

doi:10.1007/s10856-006-0064-3

Cited by 467 publications

(387 citation statements)

References 165 publications

Supporting

Mentioning

372

Contrasting

Unclassified

Order By: Relevance

“…The chemical properties of the material surface play an important role on determining the efficiency of protein adsorption and the amount of protein adsorbed by interaction between the functional groups on substratum and proteins, and even the conformation of adsorbed proteins. The chemical nature of the surface can induce greater protein-surface interactions through either electrostatic or hydrophobic interactions [104]. It is generally accepted that electrostatic force played a vital role in the protein adsorption process and has been proved by lots of experimental and computer simulation studies [98,[105][106][107] ) on HA is far different from that on OCP (figure 3).…”

Section: Protein Adsorption On Ca-p Ceramicsmentioning

confidence: 99%

A review of protein adsorption on bioceramics

et al. 2012

View full text Add to dashboard Cite

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic -protein interactions.

show abstract

Section: Protein Adsorption On Ca-p Ceramicsmentioning

confidence: 99%

A review of protein adsorption on bioceramics

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Gas discharge plasma processes are well-known for their high potential to optimize surface properties regarding specific applications, including biomedical ones [1][2][3][4][5][6]. Such application include bone contacting implants, which can be equipped with rough surfaces and hydroxylapatite coating to improve healing [7].…”

Section: Introductionmentioning

confidence: 99%

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Schröder

Finke

Polák

et al. 2010

MSF

View full text Add to dashboard Cite

Abstract.A crucial factor for in-growth of metallic implants in the bone stock is the rapid cellular acceptance whilst prevention of bacterial adhesion on the surface. Such contradictorily adhesion events could be triggered by surface properties. There already exists fundamental knowledge about the influence of physicochemical surface properties like roughness, titanium dioxide modifications, cleanness, and (mainly ceramic) coatings on cell and microbial behavior in vitro and in vivo.The titanium surface can be equipped with antimicrobial properties by plasma-based copper implantation, which allows the release and generation of small concentrations of copper ions during contact with water-based biological liquids.Additionally, the titanium surface was equipped with amino groups by the deposition of an ultrathin plasma polymer. This coating on the one hand does not significantly reduce the generation of copper ions, and on the other hand improves the adhesion and spreading of osteoblast cells.The process development was accompanied by physicochemical surface analyses like XPS, FTIR, contact angle, SEM, and AFM. Very thin modified layers were created, which are resistant to hydrolysis and delamination. These titanium surface functionalizations were found to have either an antimicrobial activity or cell-adhesive properties. Intramuscular implantation of titanium samples coated with the cell-adhesive plasma polymer in rats revealed a reduced inflammation reaction compared to uncoated titanium.

show abstract

“…Previous reports have described the significant influence that the chemical grafting of carboxyl groups onto polymeric surfaces has on osteoblast cell adhesion 39,43 . However, such an effect was not observed here.…”

Section: Discussionmentioning

confidence: 99%

Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds

et al. 2014

View full text Add to dashboard Cite

Surface modification techniques based on the grafting of chemical functional groups and immobilization of bioactive molecules have been used to improve biocompatibility and clinical performance of bioabsorbable scaffolds in tissue engineering and medicine regenerative applications. This study aimed at developing and characterizing a biomimetic surface to stimulate bone regeneration by a simple and low-cost method of surface biofunctionalization of the poly (L-co-D,L lactic acid)-PLDLA scaffolds. The method was obtained by grafting reaction of carboxyl groups (-COOH) on their surface via acrylic acid (AAc) polymerization process, followed by immobilization of collagen type I (Col). Such approach resulted in a surface morphology markedly modified after treatment, with increase of pores and roughness on PLDLA-AAc surfaces and a network of fibrillar collagen deposition in nonspecific areas of PLDLA-Col surfaces. The cytocompatibility of collagen-immobilized scaffolds was significantly improved in terms of cellular adhesion, proliferation, collagen synthesis and maintenance of osteoblast-like phenotype, indicating, therefore, the fundamental role of collagen protein over the biological interactions that occur by bio-recognition mimetic mechanisms at biomaterials interface. These results indicate that the surface modification method used here may be useful as a strategy to develop biofunctional scaffolds, which provide a more successful clinical application of biomaterials in the tissue engineering field.

show abstract

Modern biomaterials: a review—bulk properties and implications of surface modifications

Cited by 467 publications

References 165 publications

A review of protein adsorption on bioceramics

A review of protein adsorption on bioceramics

Gas-Discharge Plasma-Assisted Functionalization of Titanium Implant Surfaces

Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds

Contact Info

Product

Resources

About