Modern Assay Techniques for Cancer Drugs: Electroanalytical and Liquid Chromatography Methods

Precision Oncology by Point-of-Care Therapeutic Drug Monitoring and Dosage Adjustment of Conventional Cytotoxic Chemotherapies: A Perspective

“…Applied or not, TDM has been actually repeatedly advised for this class of therapeutics [1,7], and analytical methods presently available allow for the quantification of a wide range of cytotoxic substances [78,79]. Additionally, TDM was shown to be cost-effective in oncology for both cytotoxic agents and targeted therapeutics in a recent review [80].…”

Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) methods for the therapeutic drug monitoring of cytotoxic anticancer drugs: An update

“…Applied or not in clinics due to the many obstacles evoked in the present article, TDM has nevertheless stimulated the development of numerous analytical methods to quantify a wide range of cytotoxic chemotherapeutic agents and their relevant metabolites in patients' blood [10,[17][18][19]. Among these analytical methods, liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) stands as the gold standard, by providing unsurpassed specificity and selectivity as compared to immunoassays.…”

Electrochemistry as a Powerful Tool for Investigations of Antineoplastic Agents: A Comprehensive Review

“…All aspects related to hazardous oncological drugs illustrate that their quantitative and qualitative monitoring in biological samples both in vitro and in vivo is essential to minimize the associated risks. Many analytical techniques have been used to control ANAs, and these include, e.g., liquid chromatography coupled to various detectors, [20][21][22][23][24][25][26][27][28] gas chromatography, [21,23,24] capillary electrophoresis, [25,29] chemiluminescence, [30] or spectroscopy-based methods. [25,27,31] Although these techniques are sensitive, specific, and accurate, they require sophisticated and expensive equipment along with trained staff.…”

“…[23] These problems can be overcome with electroanalytical techniques assuring simplicity, fast response, low cost, reliability, and usually no need for a sample pretreatment process. [28] Electrochemical sensing units can be easily miniaturized, which enables the development of devices that can be used at the point-of-care analysis. [32,33] In addition, the modification of the sensing interface with nanomaterials or specific affinity layers may significantly improve the selectivity and sensitivity.…”