Modern Approaches in Wounds Management

Tatarusanu, Simona-Maria; Lupascu, Florentina-Geanina; Profire, Bianca-Stefania; Szilagyi, Andrei; Gardikiotis, Ioannis; Iacob, Andreea-Teodora; Caluian, Iulian; Herciu, Lorena; Giscă, Tudor-Catalin; Baican, Mihaela-Cristina; Crivoi, Florina; Profire, Lenuta

doi:10.3390/polym15173648

Cited by 2 publications

References 183 publications

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Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds

Urakov,

Urakova,

Reshetnikov

et al. 2024

Rev Clin Pharm Drug Ther

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It is shown that traditional treatment of chronic wounds is a course of daily single procedures of cleansing the wound surface from purulent-necrotic masses by mechanical and medicinal methods, accompanied by regular renewal of wound dressings. In this case, the procedures of medicinal wound cleansing last 10 - 15 minutes between the replacement of "old" wound dressings with "new" wound dressings. According to the established practice, medicinal sanitation of infected and purulent wounds during dressings consists in irrigation of the wound surface with cleansing solutions, solutions of antiseptics and/or antibiotics. In severe cases, the above therapy is supplemented with live larvae of the necrophage fly, which are injected into purulent-necrotic masses and left in them under wound dressings until complete cleansing of wounds from pus. Nevertheless, the effectiveness of the generally accepted course treatment of chronic wounds remains insufficiently high. It is reported that the use of pyolytics and their supplementation with wound dressings made in the form of warm wet compresses, which create a local greenhouse effect in wounds, can accelerate the healing of chronic wounds. It is shown that pyolytics is a group of antiseptics developed in Russia, which are warm alkaline solutions of hydrogen peroxide, which in interaction with purulent-necrotic masses very quickly dissolve and foam them. As a result of interaction with pyolytics, thick purulent immediately turns into fluffy oxygenated foam. It is shown that pyolytics have been developed due to physicochemical repurposing of aqueous solutions of sodium hydrogen carbonate and hydrogen peroxide. To accelerate the healing of chronic wounds it was proposed to irrigate the surface of chronic wounds with a solution of 3% hydrogen peroxide and 2-10% sodium bicarbonate, heated to a temperature of +37 - +45C, having alkaline activity at pH 8.4 - 8.5 and enriched with dissolved carbon dioxide or oxygen (due to excess pressure of 0.2 ATM). The essence of the invented technology of treatment of chronic wounds with the use of pyolytics is indicated and the results of treatment of chronic wounds with pyolytics in combination with warm moist dressings-compresses are given, which confirm the presence of wound-healing effect. Consequently, physical and chemical re-profiling of antiseptics allows turning them into effective pyolytics, and the combination of pyolytics with warm wound dressings made in the form of warm moist compresses, which create a local greenhouse effect in wounds, allows accelerating the healing of chronic wounds.

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Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds

Urakov,

Urakova,

Reshetnikov

et al. 2024

Rev Clin Pharm Drug Ther

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Biomaterials-based hydrogels for therapeutic applications

Chelu,

Magdalena Musuc

2024

Biomaterials in Microencapsulation [Working Title]

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Conventional therapeutic models based on the premise of a universal solution are facing a decrease in efficiency, emphasized by the large number of patients who show resistance or who do not respond positively to classic treatments. This perspective highlights the urgency for more precise approaches based on personalized treatments that are adaptable to the specific complexities and unique challenges faced by each patient. Hydrogels are biocompatible and biodegradable systems for well-controlled and targeted administration of therapeutic agents, being formed by 3D reticulated networks of water-soluble polymeric biomaterials, of natural, synthetic, or hybrid origin, with specific intrinsic and extrinsic properties. Due to the easily adjustable porous structure, hydrogels allow the encapsulation of macromolecular drugs, proteins, small molecules, cells, hormones, or growth factors in the gel matrix and their subsequent controlled release. The biomaterials used, the crosslinking methods, the design, and the functionalization strategies in obtaining hydrogels with improved properties are presented. The different possibilities of application are described transdermally, as dressing materials, oral, ocular, spray-able, or injectable, up to the intracellular level. This chapter extensively investigates the advances and unique advantages of hydrogels that enable effective, noninvasive, personalized treatments and provide greater patient comfort for a wide range of applications.

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Modern Approaches in Wounds Management

Cited by 2 publications

References 183 publications

Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds

Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds

Biomaterials-based hydrogels for therapeutic applications

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