Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation

Washington, N.; Harris, Margaret; Mussellwhite, Amanda; Spiller, Robin C.

doi:10.1093/ajcn/67.2.237

Cited by 83 publications

(42 citation statements)

References 30 publications

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“…decreasing the viscosity of hard stool in constipation (softer stool, increased transit rate, improved bowel movement frequency), and increasing the viscosity of loose/liquid stool in diarrhea (firmer stool, slower transit rate, less frequent bowel movements) [3,[66][67][68] . The gel-forming, water-holding capacity of psyllium has been shown to soften hard stool better than docusate, a marketed stool softener [59] , and to firm loose/liquid stool in diarrhea, normalizing stool form [66][67][68] .…”

Section: Ge Intesmentioning

confidence: 99%

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A review of gastrointestinal physiology and the mechanisms underlying the health benefits of dietary fiber: Matching an effective fiber with specific patient needs

McRorie¹,

Fahey²

2013

Clinical Nursing Studies

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A primary function of the gastrointestinal tract is to provide the body with water, electrolytes and nutrients. It accomplishes this by ingestion, mechanical shearing, mixing and movement of the food through the gastrointestinal tract (motor events), secretion of digestive juices (≈ 6 liters per day) for degradation of complex nutrients into simple nutrients (e.g. complex carbohydrate into simple sugars), absorption of simple nutrients, water and electrolytes, and bacterial degradation of residue in the large bowel / elimination of waste. The small bowel is ≈ 7 meters long with a mucosa that is studded with millions of villi (each with microvilli), giving the small bowel a surface area approximately the size of a tennis court. Most digestion/absorption normally occurs early in the proximal small bowel. Non-digested/absorbed chyme arrives as a liquid in the cecum, and, under normal conditions, is gradually dehydrated as it slowly passes through the large bowel until it is eliminated as formed stool. Different types of dietary fiber can exert specific mechanical effects on each of these gastrointestinal functions, which can lead to local benefits (e.g. relief of constipation) as well as systemic benefits (e.g. cholesterol lowering, improved glycemic control). Three characteristics of fiber (solubility, viscosity and fermentation) are predictive of the health benefits of different fiber types. Based on these three characteristics, dietary fiber can be divided into four clinically meaningful designations that support recommendations to address the specific healthcare needs of each patient. This review will describe the four clinically meaningful designations for dietary fiber, and provide a summary of the clinical studies that support the health benefits for each.

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Section: Ge Intesmentioning

confidence: 99%

“…The gel-forming, water-holding capacity of psyllium has been shown to soften hard stool better than docusate, a marketed stool softener [59] , and to firm loose/liquid stool in diarrhea, normalizing stool form [66][67][68] . The stool normalizing benefit (e.g.…”

Section: Ge Intesmentioning

confidence: 99%

A review of gastrointestinal physiology and the mechanisms underlying the health benefits of dietary fiber: Matching an effective fiber with specific patient needs

McRorie¹,

Fahey²

2013

Clinical Nursing Studies

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“…The husk obtained after milling is white hydrophilic material forming clear and colorless mucilaginous gel after water absorption. Psyllium seed husk is composed of mucilaginous polysaccharides, with a highly branched acidic arabinoxylan containing a xylan backbone (Washington et al, 1998 andBlumenthal et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Studies on Exploration of Psyllium Husk as Prebiotic for the Preparation of Traditional Fermented Food “Buttermilk”

Shree¹,

Deshpande²,

Bhate³

2017

Int.J.Curr.Microbiol.App.Sci

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“…Recently, psyllium was used for the controlled delivery of peptides such as insulin [22] . It has been shown that psyllium could reduce the concentration of low-density lipoprotein (LDL) and cholesterol in the plasma, [23] and can be used in the treatment of irritable bowel syndrome (IBS), [24][25][26][27] maintaining remission in ulcerative colitis, [28,29] and inhibiting carcinogenic processes. [30,31] Psyllium not only has pharmacological importance but it also can be used to develop drug delivery devices such as sustained release matrix tablets and hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymers

Kaialy

Emami

Asare-Addo

et al. 2013

Pharmaceutical Development and Technology

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Psyllium has a mucilaginous property that makes it a good candidate to be utilized as an excipient in the preparation of controlled release systems. Various formulations were prepared using theophylline as a model drug and investigated with view to achieve an ideal slow drug release profile. The addition of HPMC to psyllium significantly reduced burst release however the percentage of drug release within a 12 h period was too slow and thereby inadequate. This was overcome by the addition of lactose as hydrophilic filler which enabled a slow release with roughly 80% drug release in 12 h. The inclusion of HPMC within psyllium formulations changed the drug release kinetics from Fickian diffusion to anomalous transport. Granulated formulations demonstrated slower drug release than ungranulated or physical mixture and caused a change in dissolution kinetics from Fickian diffusion to anomalous transport. Milled granules showed more efficient controlled drug release with no burst release. Milling of the granules also changed the drug release kinetics to anomalous transport. Although, psyllium was proved to be a promising polymer to control the drug release, a combination of psyllium-HPMC and formulation processes should be considered in an attempt to achieve a zero-order release.

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Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation

Cited by 83 publications

References 30 publications

A review of gastrointestinal physiology and the mechanisms underlying the health benefits of dietary fiber: Matching an effective fiber with specific patient needs

A review of gastrointestinal physiology and the mechanisms underlying the health benefits of dietary fiber: Matching an effective fiber with specific patient needs

Studies on Exploration of Psyllium Husk as Prebiotic for the Preparation of Traditional Fermented Food “Buttermilk”

Psyllium: a promising polymer for sustained release formulations in combination with HPMC polymers

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