Moderation of hematological and plasma biochemical indices of sub-chronic salt-loaded rats by aqueous extract of the sclerotia of Pleurotus tuberregium (Fr) Sing's: Implications for the reduction of cardiovascular risk

Ikewuchi, Jude Chigozie; Ikewuchi, Catherine C.; Ifeanacho, Mercy O.; Igboh, Ngozi M.; Ijeh, Ifeoma I.

doi:10.1016/j.jep.2013.09.002

Cited by 25 publications

(23 citation statements)

References 47 publications

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“…The saponins' extraction was carried out in a similar manner as the one reported by Guo, Zhang, and Liu (2009). The extract obtained was subjected to gas chromatography with similar conditions as was earlier reported by Ikewuchi et al (2013). The terpenes' extraction was carried out in a similar way as reported by Ortan et al (2009).…”

Section: Determination Of Phytochemical Compositionmentioning

confidence: 88%

“…Extraction of oil was carried out according to the AOAC method 999.02 (AOAC International, 2006), while the analysis of sterols was carried out according to the AOAC method 994.10 (AOAC International, 2006) with similar gas chromatographic conditions as was earlier reported by Ikewuchi et al (2011). The glycosides' extract was obtained in a similar manner as the one reported by Oluwaniyi and Ibiyemi (2007), and subjected to gas chromatography, with similar conditions as earlier reported by Ikewuchi, Ikewuchi, Ifeanacho, Igboh, and Ijeh (2013). The allicins' extraction was carried out in a similar way as reported by Roy, Shakleya, Callery, and Thomas (2006); and the resultant extract was subjected to gas chromatography with similar conditions as was earlier reported by Ikewuchi et al (2013).…”

Section: Determination Of Phytochemical Compositionmentioning

confidence: 90%

“…The carotenoids' extract was prepared according to the method of Rodriguez-Amaya and Kimura (2004) (2007), and subjected to gas chromatography, with similar conditions as earlier reported by Ikewuchi, Ikewuchi, Ifeanacho, Igboh, and Ijeh (2013). The allicins' extraction was carried out in a similar way as reported by Roy, Shakleya, Callery, and Thomas (2006); and the resultant extract was subjected to gas chromatography with similar conditions as was earlier reported by Ikewuchi et al (2013). The saponins' extraction was carried out in a similar manner as the one reported by Guo, Zhang, and Liu (2009).…”

Section: Determination Of Phytochemical Compositionmentioning

confidence: 99%

“…The terpenes' extraction was carried out in a similar way as reported by Ortan et al (2009). The resultant extract was subjected to gas chromatography, with similar conditions as was earlier reported by Ikewuchi et al (2013).…”

Section: Determination Of Phytochemical Compositionmentioning

confidence: 99%

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Bioactive phytochemicals in an aqueous extract of the leaves of Talinum triangulare

Ikewuchi

Ifeanacho

2016

Food Science & Nutrition

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An aqueous leaf extract of Talinum triangulare was screened for the presence of bioactive molecules, using gas chromatography coupled with pulse and flame ionization detectors. It had high carotenoids; moderate benzoic acid derivatives, hydroxycinnamates and flavonoids; and low terpenes, alkaloids, phytosterols, allicins, glycosides, saponins, and lignans contents. Ten known carotenoids (mainly 50.42% carotene and 33.30% lycopene), nine benzoic acid derivatives (mainly 84.63% ferulic acid and 11.92% vanillic acid), and six hydroxycinnamates (55.44% p‐coumaric acid and 44.46% caffeic acid) were detected. Also detected were eight lignans (88.02% retusin) and thirty flavonoids (50.35% quercetin and 39.36% kaempferol). The medicinal properties of the major components of these phytochemical families that were detected in the aqueous extract of the leaves were discussed herein and proposed to be explored for their potential health benefits. The great number of potentially active biomolecules and their multifunctional properties make Talinum triangulare a ready source of health‐promoting substances.

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Section: Determination Of Phytochemical Compositionmentioning

confidence: 88%

Section: Determination Of Phytochemical Compositionmentioning

confidence: 90%

Section: Determination Of Phytochemical Compositionmentioning

confidence: 99%

Section: Determination Of Phytochemical Compositionmentioning

confidence: 99%

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Bioactive phytochemicals in an aqueous extract of the leaves of Talinum triangulare

Ikewuchi

Ifeanacho

2016

Food Science & Nutrition

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“…The atherogenic indices were calculated using the following formulae: Cardiac risk ratio = [Total cholesterol]/[HDL cholesterol] (Ikewuchi & Ikewuchi, ) Atherogenic coefficiecnt = ([Non‐HDL cholesterol])/([HDL cholesterol]) (Ikewuchi, Ikewuchi, Ifeanacho, Igboh, & Ijeh, ) Castelli's risk index II = [LDL cholesterol]/[HDL cholesterol] (Bhardwaj, Bhattacharjee, Bhatnagar, & Tyagi, ) Atherogenic index of plasma = log ([Triglyceride])/([HDL cholesterol]) (Ikewuchi, Onyeike, Uwakwe, & Ikewuchi, ) …”

Section: Methodsmentioning

confidence: 99%

Effect of “edible clay” (takere) suspension on serum lipid profiles and atherogenic indices of normal Wistar rats

Ikewuchi

Ezeka

et al. 2019

Food Science & Nutrition

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This study was undertaken to ascertain the effect of an aqueous suspension of a commonly available preparation of edible clay (“takere”) on serum lipid profiles and atherogenic indices of normal Wistar rats. Ninety‐five adult Wistar rats of average weight of 100 g were assigned into seven groups. Group 1 (Baseline) was immediately sacrificed at the commencement of study; Group 2 (Control) daily received distilled water, orally; and Groups 3 to 7 received via the same route (per body weight), 125 mg/kg (T125), 250 mg/kg (T250), 500 mg/kg (T500), 1,000 mg/kg (T1000), and 2,000 mg/kg (T2000) of the takere suspension, respectively, for 28 days. In week 1, the treatments significantly ( p < 0.05) lowered the levels of serum triglyceride (by T250, T1000, and T2000), VLDL cholesterol (by T250, T1000, and T2000), and atherogenic index of plasma ( AIP ; by T250) and significantly ( p < 0.05) raised the levels of serum HDL (T250), LDL (T250 and T2000), non‐ HDL (T2000) cholesterols, atherogenic coefficient ( AC ; T2000), cardiac risk ratio ( CRR ; T2000), and Castelli's risk index II ( CRI ‐ II ; T2000) of the rats. In week 2, the treatments significantly ( p < 0.05) lowered the levels of serum triglyceride (T2000), HDL (T125, T500, T1000, and T2000), VLDL (T2000) cholesterols and significantly ( p < 0.05) raised levels of serum LDL (T125, T1000, and T2000), non‐ HDL (T125, T1000, and T2000) cholesterols, AC (T125, T500, and T1000), CRR (T125, T500, and T1000), CRI ‐ II (T125 and T1000), AIP (T125, T500, and T1000) of the rats. In week 4, the treatments significantly ( p < 0.05) raised the levels of serum total (T500 and T2000), HDL (T2000), non‐ HDL (T500 and T1000) cholesterols, AC (T500), CRR (T500), and CRI ‐ II (T500). This result indicates that the consumption of takere suspension may have adverse effects on serum lipid profiles and atherogenic indices of Wistar rats, at least at the doses administered in this study.

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A Review on Bioactive Compounds, Ethnomedicinal Importance and Pharmacological Activities of Talinum triangulare (Jacq.) Willd

Dinesh,

Kumar

2023

Chemistry & Biodiversity

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Talinum triangulare (Jacq.) Willd. is a traditional leafy vegetable used by tribal communities for ethnomedicinal and ethnoculinary preparations. This article reviews the current knowledge of its multiple uses, including pharmacological activities and nutritional composition. The literature survey shows that it has been traditionally useful in the treatment of several diseases, such as anaemia, diabetes, measles, and ulcers and the preparation of various traditional foods. Analysis of the literature on its phytochemicals shows its richness in bioactive compounds. Further, research also shows that this plant has antidiabetic, antiobesity, antitumor, antiulcer, hepatoprotective, and neuroprotective activities besides anti‐inflammatory and antioxidant properties. Nutrient analysis of the plant reveals the presence of Ca, Zn, Fe, vitamins C and E, dietary fibre and protein in considerable quantities. The results of the pharmacological studies on the antidiabetic, antiulcer and anti‐anaemic activities provide support in favour of its ethnomedicinal uses. The presence of bioactive compounds and pharmacological activities show the usefulness of this plant as a functional food.

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Moderation of hematological and plasma biochemical indices of sub-chronic salt-loaded rats by aqueous extract of the sclerotia of Pleurotus tuberregium (Fr) Sing's: Implications for the reduction of cardiovascular risk

Cited by 25 publications

References 47 publications

Bioactive phytochemicals in an aqueous extract of the leaves of Talinum triangulare

Bioactive phytochemicals in an aqueous extract of the leaves of Talinum triangulare

Effect of “edible clay” (takere) suspension on serum lipid profiles and atherogenic indices of normal Wistar rats

A Review on Bioactive Compounds, Ethnomedicinal Importance and Pharmacological Activities of Talinum triangulare (Jacq.) Willd

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