Moderate wine drinkers have lower hypertension-related mortality: a prospective cohort study in French men

Renaud, S.; Guéguen, R; Conard, Pascale; Lanzmann‐Petithory, Dominique; Orgogozo, Jean‐Marc; Henry, Olivier

doi:10.1093/ajcn/80.3.621

Cited by 68 publications

(29 citation statements)

References 21 publications

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“…No comparisons were made with normotensive individuals. Total mortality has been investigated in prior studies [9,[12][13][14]24], but with inconsistent conclusions about the potential beneficial effects of a light-to-moderate alcohol intake in men with hypertension [9,14]. We found that moderate drinkers had a lower all-cause mortality than non-drinkers and heavy drinkers, which seems to apply to both men and women with normal blood pressure and hypertension.…”

Section: Discussionmentioning

confidence: 65%

Alcohol intake and risk of acute coronary syndrome and mortality in men and women with and without hypertension

et al. 2011

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Although a light to moderate alcohol intake is associated with a lower risk of acute coronary syndrome (ACS), alcohol is also associated with risk of hypertension, which in turn is a strong risk factor of ACS. We examined whether middle-aged men and women with hypertension also benefit from a light to moderate alcohol intake in relation to risk of ACS and overall mortality. We used data from 57,053 men and women, aged 50-64, who participated in the Danish Diet, Cancer and Health study. Information on alcohol intake (amount and frequency) was reported by the participants. Hypertension status was assessed at baseline by combining blood pressure measurements and self-reports. During follow-up, 860 and 271 ACS events occurred among men and women. Irrespective of alcohol intake, participants with hypertension had a higher risk than participants with normal blood pressure. Alcohol intake was associated with a lower risk of ACS among participants both with and without hypertension and there was no evidence of interaction between alcohol intake and hypertension. Those who drank moderately had a lower mortality than abstainers and those who drank heavily; and for all levels of alcohol intake, participants with hypertension had a higher risk than participants with normal blood pressure. Results were similar for men and women. These findings indicate that a light to moderate alcohol intake has similar effects on the risk of ACS in men and women with and without hypertension.

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Section: Discussionmentioning

confidence: 65%

Alcohol intake and risk of acute coronary syndrome and mortality in men and women with and without hypertension

et al. 2011

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“…Recent large epidemiological studies on cardiovascular health include those by Grønbaek et al [55] (13,064 men and 11,459 women; follow-up about 10 years), Renaud et al [56] (36,583 men; follow-up 13-21 years), and Klatsky et al [57] (56,926 men and 72,008 women; followup 20 years or known death). From these studies, a conservative estimate on the reduced risk of cardiovascular mortality for moderate drinkers of red wine (1-3 glasses a day) amounts to 0.7 compared to nondrinkers.…”

Section: Studies On Winementioning

confidence: 99%

The Protective Effect of the Mediterranean Diet: Focus on Cancer and Cardiovascular Risk

Pauwels¹

2011

Med Princ Pract

120

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The lower occurrence of cancer and cardiovascular disease in the population around the Mediterranean basin has been linked to the dietary habits of the region. Indeed, this so-called Mediterranean diet is essentially different from the diets consumed in Western and Northern European countries and is rich in nuts, fruits, vegetables, legumes, whole-wheat bread, fish, and olive oil, with moderate amounts of red wine, which is mainly consumed during meals. Although a variety of cultural and religious traditions exist among the peoples of the Mediterranean area, olive oil, fish, and red wine hold a traditional and central position in the culinary routines of the region. The components of the diet contain an ample source of molecules with antioxidant and anti-inflammatory actions, among which omega-3 fatty acids, oleic acid, and phenolic compounds hold a prominent place. This review will summarize the results of important epidemiological studies that have investigated the protective effect of fish and olive oil on the risk of breast, prostate, and colorectal cancer and of wine on the risk of cardiovascular disease. The present review also aims to elucidate the various mechanisms by which various dietary components exhibit their beneficial action. In this respect, emphasis will be placed on the properties of omega-3 fatty acids from fish, oleic acid from olive oil, and phenolic compounds from olive oil and red wine.

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“…Previous studies on resveratrol and wine polyphenols were indicative of their role in the prevention of cardiovascular diseases, since a number of epidemiological findings À known as "French Paradox" À have revealed an inverse correlation between the red wine consumption and cardiovascular disease incidences (Renaud & de Lorgeril, 1992;Renaud et al, 2004). In addition, trans-resveratrol exhibits significant anticancer (Jang et al, 1997), antiinflammatory, antibacterial, (Chan, 2002) and phytoestrogenic properties (Gehm, McAndrews, Chien, & Jameson, 1997).…”

Section: Introductionmentioning

confidence: 99%

Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties

Anastasiadi

Pratsinis

Kletsas

et al. 2012

LWT - Food Science and Technology

116

122

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Moderate wine drinkers have lower hypertension-related mortality: a prospective cohort study in French men

Abstract: A moderate intake of wine is associated with a lower risk of mortality from all causes in persons with hypertension.

Cited by 68 publications

References 21 publications

Alcohol intake and risk of acute coronary syndrome and mortality in men and women with and without hypertension

Alcohol intake and risk of acute coronary syndrome and mortality in men and women with and without hypertension

The Protective Effect of the Mediterranean Diet: Focus on Cancer and Cardiovascular Risk

Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties

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