Moderate-to-severe early-onset hyperuricaemia: a prognostic marker of long-term kidney transplant outcome

Yun, Ik Jin; Kang, Jin Mo; Park, Yang Jin; Min, Sang Il; Ahn, Curie; Kim, Sang Joon; Ha, Jong‐Won

doi:10.1093/ndt/gfp192

Cited by 30 publications

(35 citation statements)

References 26 publications

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“…But this is in contraindication to another study by Kanby M who found that uric acid level didn't differ significantly between renal transplant recipients receiving cyclosporine and non calcinurin inhibitors 36 . Also during the course of study 15% of normouricemic patients after 1 month of kidney transplant were converted at 6 months to patients having high uric acid level (data not shown).Our finding is consistent with adult kidney transplantation 37,38 and other solid organ transplantation 39,40,41 .…”

Section: Discussionsupporting

confidence: 84%

A retrospective study of hyperurecemia in renal transplant recipients

Baruah

Datta

Nath

et al. 2014

Int Jour of Biomed Res

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Section: Discussionsupporting

confidence: 84%

A retrospective study of hyperurecemia in renal transplant recipients

Baruah

Datta

Nath

et al. 2014

Int Jour of Biomed Res

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“…Late-onset hyperuricemia mainly develops because of a gradual decrease in graft function, and it should therefore be regarded as a marker of chronic allograft nephropathy [13]. In contrast, early-onset hyperuricemia can develop without regard to reduced graft function and many previous reports suggest that it may play a predictive role in allograft outcome.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Early-Onset Hyperuricemia in Renal Transplant Recipients

Chung¹,

Kang²,

Hwang³

et al. 2010

Nephron Clin Pract

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Background/Aims: It is undetermined whether the effect of uric acid (UA) on graft outcome is independent of graft dysfunction. This study was designed to explore whether early-onset hyperuricemia has clinical significance regardless of graft function. Methods: This study was conducted based on a retrospective chart review. We calculated time-averaged UA and estimated glomerular filtration rate from the values at 3, 6, and 9 months after transplantation. Cardiovascular complications during follow-up and long-term graft survival were assessed according to UA levels and graft function. Results: 351 patients were enrolled into this study. Hyperuricemia increased the risk of cardiovascular complications (HR = 2.8, 95% CI 1.1–7.1; p = 0.02), but reduced graft function did not. In the hyperuricemia group, 5- and 10-year graft survival was significantly lower than in the normouricemia group (89 and 81% vs. 96 and 92%, respectively; p = 0.02). In the reduced graft function group, these values were also lower than in the normal graft function group (89 and 81% vs. 96 and 93%, respectively; p = 0.02). In the multivariate analysis, both hyperuricemia and reduced graft function were independent risk factors for graft failure and the presence of both factors presented the highest risk. Conclusion: Early-onset hyperuricemia is a significant predictor of cardiovascular complications and graft survival independently of graft function.

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“…Some studies indicate that HUA is only a marker of graft dysfunction, [136][137][138][139] whereas some other studies suggest that UA is an independent risk factor for graft dysfunction. [140][141][142][143][144][145][146] Recently, Hart et al 147 reported that HUA correlated with tubular atrophy and interstitial fibrosis in chronic allograft nephropathy. Similar to the experimental findings, HUA in humans may exacerbate CsA nephrotoxicity.…”

Section: Hua and Renal Transplantationmentioning

confidence: 99%

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

et al. 2014

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The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation.

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Moderate-to-severe early-onset hyperuricaemia: a prognostic marker of long-term kidney transplant outcome

Abstract: Moderate-to-severe early-onset hyperuri- caemia may be a prognostic marker of the long-term graft outcome in RTRs, which needs further investigation.

Cited by 30 publications

References 26 publications

A retrospective study of hyperurecemia in renal transplant recipients

A retrospective study of hyperurecemia in renal transplant recipients

Clinical Significance of Early-Onset Hyperuricemia in Renal Transplant Recipients

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

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