Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis

Fernandes, Olavo; Sabharwal, Mona; Smiley, Tom; Pastuszak, Anne; Koren, Gideon; Einarson, Thomas R.

doi:10.1016/s0890-6238(98)00024-0

Cited by 108 publications

(63 citation statements)

References 35 publications

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“…However, our results should be interpreted with caution in consideration of methodological limitations of the original studies and other potential issues such as residual confounding and publication bias that may have influenced our results. Most previous reviews on maternal caffeine intake and pregnancy loss included only a qualitative summary of the evidence (17,48,49) , used estimates that were not adjusted for potential confounders (50) or included only five studies on preconception caffeine intake (51) . A recent meta-analysis reported significant associations stronger than those observed in our meta-analysis between higher maternal caffeine intakes and higher risks of miscarriage (summary RR = 1·14 per 100 mg caffeine/d, 95 % CI 1·10, 1·19 in that study compared with 1·08, 95 % CI 1·04, 1·13 in our study) and stillbirth (summary RR = 1·19, 95 % CI 1·05, 1·35 in that study compared with 1·09, 95 % CI 1·02, 1·16 in our study) (18) .…”

Section: Discussionmentioning

confidence: 99%

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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Objective: To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis. Design: Categorical and dose-response meta-analysis of prospective studies. Setting: Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95 % CI for specific categories of caffeine consumption and for a continuous association using generalized leastsquares trend estimation. Subjects: A total of 130 456 participants and 3429 cases in fourteen included studies. Results: Compared with the reference category with no or very low caffeine intake, the RR (95 % CI) of pregnancy loss was 1·02 (0·85, 1·24; I 2 = 28·3 %) for low intake (50-149 mg/d), 1·16 (0·94, 1·41; I 2 = 49·6 %) for moderate intake (150-349 mg/d), 1·40 (1·16, 1·68; I 2 = 18·6 %) for high intake (350-699 mg/d) and 1·72 (1·40, 2·13; I 2 = 0·0 %) for very high intake (≥700 mg/d). In the dose-response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7 % (95 % CI 3 %, 12 %) higher risk of pregnancy loss. Our results may have been affected by publication bias, but the association remained significant for the subset of larger studies. Furthermore, adjustment for smoking and pregnancy symptoms may have been incomplete, potentially resulting in residual confounding. Conclusions: Albeit inconclusive, higher maternal caffeine intake was associated with a higher risk of pregnancy loss and adherence to guidelines to avoid high caffeine intake during pregnancy appears prudent.

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Section: Discussionmentioning

confidence: 99%

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Chen

Neelakantan

et al. 2015

Public Health Nutr.

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“…In humans, studies have reached mixed conclusions, in part because of difficulties measuring caffeine intake, but also because of other clinical influences on fetal growth and birth outcomes [4][5][6]. Only one randomised controlled trial of caffeine reduction during pregnancy has been conducted to date, concluding that "moderate reductions" in caffeine intake (of around 200mg) do not substantially alter birthweight or length of gestation [7].…”

Section: Introductionmentioning

confidence: 99%

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

et al. 2014

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“…Ces deux substances sont des métabolites de la caféine, obtenus après ingestion de café correspondant à une dose de 300 mg de caféine. Le café est un produit qui s'avère être non toxique même à dose élevée, il n'a pas de contre-indication et l'expression du phénotype de la caféine n'est pas influencée par l'âge, ni par le sexe [38][39][40]. Le choix de ce test est basé sur son utilisation simple, sa sécurité relative [33,[41][42][43].…”

Section: Discussionunclassified

Détermination du polymorphisme d’acétylation de la N-acétyltransférase 2 dans la population sénégalaise par utilisation du test à la caféine

Touré¹,

Cabral²,

Diop³

et al. 2012

Ann Toxicol Anal

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Résumé -Introduction : L'isoniazide (INH) est métabolisée par une N-acétyltransfèrase (NAT), la NAT2. Il existe de nombreux polymorphismes de la NAT2 qui peuvent être associés à des toxicités ou à des échecs thérapeutiques au cours d'un traitement par INH. Objectif : L'objectif de ce travail est de déterminer l'indice d'acétylation de la NAT2 dans la population sénégalaise afin de les répartir en acétyleurs lents et rapides. Méthodes : L'étude du profil d'acétylation a été effectuée sur des urines de 247 sujets en utilisant la caféine comme marqueur. La proportion molaire du 5-acétamino-6-formylamine-3-méthyluracile (AFMU) sur le 1-méthylxanthine (1X) a été déterminée. La répartition de la population étudiée en phénotype lent ou rapide a été réalisée en se basant sur l'antimode = 0,55. Les sujets possédant un rapport ([AFMU]/[1X]) inférieur à 0,55 sont considérés comme des acétyleurs lents et ceux dont le rapport est >0,55 sont des acétyleurs rapides. Résultats : Les résultats obtenus ont montré une ségrégation en deux modes apparents de capacité d'acétylation dans la population sénégalaise testée avec 63,8 % et 36,2 % d'acétyleurs lents et rapides respectivement. Conclusion : La réponse au traitement de maladies comme la tuberculose dépend du polymorphisme d'acétylation de la NAT2, il est donc important de connaître le phénotype de la NAT2 chez les sujets atteints de tuberculose pour éviter des effets indésirables tels que l'hépatotoxicité ou la neurotoxicité. Mots clés : N-acétyltransférase, polymorphisme, indice d'acétylation, test caféineAbstract -Introduction: Isoniazid (INH) is metabolized by an N-acetyltransferase (NAT), the NAT2. There are many of NAT2 polymorphisms that may be associated to toxicity or therapeutic failure of INH. Objective: The objective of this study is to determine the index of acetylation of NAT2 in the Senegalese population. Methods: The study of the profile of acetylation was performed on urine from 247 subjects using caffeine as a marker. The molar ratio of 5-acetamino-6-formyl amine-3-methyluracil (AFMU) on the 1-methylxanthine (IX) was determined. The distribution of the population studied in slow or fast phenotype was performed based on the antimode = 0.55. Subjects who have ratio ([AFMU]/[IX]) less than 0.55 are considered slow acetylators and those, whose ratio is >0.55, are rapid acetylators. Results:The results showed segregation of two apparent modes of acetylation capacity in the Senegalese population tested with 63.8% and 36.2% of slow and fast acetylators respectively. Conclusion: Response to treatment of diseases such as tuberculosis depends on the polymorphism of NAT2 acetylation, it is significant to know the phenotype of NAT2 in patients with tuberculosis to avoid such side effects as hepatotoxicity or neurotoxicity.

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Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis

Cited by 108 publications

References 35 publications

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose–response meta-analysis of prospective studies

Caffeine intake during pregnancy and adverse birth outcomes: a systematic review and dose–response meta-analysis

Détermination du polymorphisme d’acétylation de la N-acétyltransférase 2 dans la population sénégalaise par utilisation du test à la caféine

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