Moderate static magnetic fields enhance antitumor CD8+ T cell function by promoting mitochondrial respiration

Abstract

With the discovery of magnetoreceptor mechanisms in animals, it materialized the novel applications of controlling cell and animal behaviors using magnetic fields. T cells have shown to be sensitive to magnetic fields. Here, we reported that exposure to moderate SMFs (static magnetic fields) led to increased granule and cytokine secretion as well as ATP production and mitochondrial respiration from CD8 + T cells. These effects were inhibited by knocking down the Uqcrb and Ndufs6 genes of mitochondrial respiratory chain, whose transcriptions were regulated by candidate magnetoreceptor genes Isca1 and Cry1 / Cry2 . SMF exposure also promoted CD8 + T cell granule and cytokine secretion and repressed tumor growth in vivo. SMFs enhanced CD8 + T cell cytotoxicity, and the adoptive transfer into tumor-bearing mice resulted in enhanced antitumor effects. Collectively, our study suggests that moderate SMFs enhance CD8 + T cell cytotoxicity by promoting mitochondrial respiration and promoted the antitumor function of CD8 + T cells.

A moderate static magnetic field promotes C. elegans longevity through cytochrome P450s

“…Consistently, we found that mutating tax-4 could affect the SMF-dependent upregulation of three CYP genes. Moreover, recent studies on cellular effects of SMFs, together with our findings, highlight the role of mitochondria 8 , 9 , suggesting mitochondria could be an SMF sensor in the cell. Exploring the transcription factors driving the transcriptomic changes upon SMF treatment is another exciting issue to pursue.…”

“…S1 ). Similarly, a recent report showed that 0.3 T SMF is more potent than 0.6 T SMF in inducing cytokine secretion of CD8 + T cells 8 . The dose-dependent feature of SMF-induced biological effects makes it intriguing to find optimal SMF treatment in the future.…”

“…A recent report shows that moderate SMF promotes mitochondrial respiration 8 . Since mitochondria are also critical in ageing 1 , we next checked the impact of SMF on mitochondria morphology in the body wall muscle (BWM) of worms at different ages.…”

“…Other organisms across taxa, such as butterflies, salmon, and birds, are considered to navigate over long distances by tracing GMF 5 – 7 . The moderate magnetic field has recently been shown to regulate immune cell function and redox homeostasis 8 – 10 . Given its various biological effects, it is intriguing to explore the potential influence of the moderate magnetic field in ageing and the underlying mechanisms.…”

Human Cryptochrome Mediates Oxidative Stress Responses Modulated by Static and Electromagnetic Fields in Doxorubicin-Treated Cells

“…MFs can be classi ed the static magnetic elds (SMF) in various intensity ranges including week (< 1 mT), moderate (1 mT-1 T) and high (1 T <), and also electromagnetic eld (EMF) in various frequency including extremely low-frequency (< 300 Hz), intermediate (300 Hz-10 MHz) and radiofrequency (10 MHz-300 GHz) 6,7 . Moreover, pulsed EMF (PEMF) represent a sub-class of EMFs containing frequencies from 6 Hz up to 500 Hz 8,9 .…”