Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma

Melander, Olle; Wowern, Fredrik von; Frandsen, Erik; Burri, Philippe; Willsteen, Gunilla; Aurell, Mattias; Hulthén, U L

doi:10.1097/hjh.0b013e328013cd50

Cited by 65 publications

(49 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…76 In contrast, other investigators have failed to detect differences in the ANP responses to high-salt intake between SS and SR subjects, 77 and some actually detected significantly higher levels of ANP in SS than SR, 78 whether on high-(220 mEq/d) or low-(20 mEq/d) salt diets. 79 Finally, opposite to the observations on N-terminal ANP in the Framingham cohort, increased levels of plasma pro-ANP have been shown to be predictors of SSBP in normal volunteers 80 and prehypertensive subjects. 81 This controversial information in humans can be reconciled only if ANP plays a pathogenic role in the BP response to salt in some SS subjects, whereas it is stimulated as a compensatory response to hypertension in others, analogous to the observations in different genetic SS strains of rats.…”

Section: Atrial Natriuretic Peptides (Anps)mentioning

confidence: 60%

Salt Sensitivity of Blood Pressure

Elijovich¹,

Weinberger²,

Anderson³

et al. 2016

Hypertension

370

230

View full text Add to dashboard Cite

The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee on January 23, 2016, and the American Heart Association Executive Committee on February 23, 2016. A copy of the document is available at http://professional.heart.org/statements by using either "Search for Guidelines & Statements" or the "Browse by Topic" area. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@ wolterskluwer.com.The American Heart Association requests that this document be cited as follows: Elijovich F, Weinberger MH, Anderson CAM, Appel LJ, Bursztyn M, Cook NR, Dart RA, Newton-Cheh CH, Sacks FM, Laffer CL; on behalf of the American Heart Association Professional and Public Education Committee of the Council on Hypertension; Council on Functional Genomics and Translational Biology; and Stroke Council. Salt sensitivity of blood pressure: a scientific statement from the American Heart Association. Hypertension. 2016;68:e7-e46. doi: 10.1161/HYP.0000000000000047.Expert peer review of AHA Scientific Statements is conducted by the AHA Office of Science Operations. For more on AHA statements and guidelines development, visit http://professional.heart.org/statements. Select the "Guidelines & Statements" drop-down menu, then click "Publication Development."Permissions: Multiple copies, modification, alteration, enhancement, and/or distribution of this document are not permitted without the express permission of the American Heart Association. Instructions for obtaining permission are located at http://www.heart.org/HEARTORG/General/CopyrightPermission-Guidelines_UCM_300404_Article.jsp. A link to the "Copyright Permissions Request Form" appears on the right side of the page. Figure 2 shows the major effect of aging in increasing the prevalence of SSBP in both normotensive and hypertensive subjects. An important and encouraging observation is that the multiple phenotypic characteristics described in pure SS strains of rodents reproduce those observed in humans, indicating that the phenotypic cluster of SSBP can be brought out in humans by the current techniques used in carefully controlled research. Additionally, despite the unquestionable influence of environmental factors in the determination of SSBP in humans, estimates of its heritability have been as high as 74% in blacks 9 and 50% in Chinese subjects, 10 both higher than those for hypertension. Salt Sensitivity of Blood PressureAn important issue is the clinical significance of the SSBP phenotype. There was increasing understanding that it represents an abnormality. The reasons w...

show abstract

Section: Atrial Natriuretic Peptides (Anps)mentioning

confidence: 60%

Salt Sensitivity of Blood Pressure

Elijovich¹,

Weinberger²,

Anderson³

et al. 2016

Hypertension

370

230

View full text Add to dashboard Cite

show abstract

“…Chimpanzees fed with high-sodium diets show a consistent increase in blood pressure that also consistently decreases when the sodium content of the diet is reduced (Denton et al 1995). A similar parallel between sodium intake and blood pressure is seen in healthy humans, where a low-salt diet is associated with a significant reduction in arterial blood pressure (Melander et al 2007). Most of the complications arising from an elevated salt intake apparently derive from inefficient physiologic mechanisms implemented to maintain sodium homeostasis.…”

Section: The Salt Factormentioning

confidence: 87%

Salt, Na+,K+-ATPase and hypertension

Jaitovich

Bertorello

2010

Life Sciences

View full text Add to dashboard Cite

“…One may, however, speculate what will happen with blood pressure in the next decades if the high Na intake is maintained, as the kidneys' ability to excrete excess Na is reduced with age (18,19) . It is well known that reducing salt intake reduces blood pressure moderately but significantly in hyper-as well as normotensive middle-aged men and women (1,3,4,20) . This fact is underlined in the extensively controlled meta-analysis by He and MacGregor (3) , based on twenty-eight carefully selected studies with in total 734 hypertensive and 2220 normotensive individuals.…”

Section: Discussionmentioning

confidence: 99%