Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet☆

Bargalló, Montserrat Vadillo; Ardévol, Anna; Fernández-Larrea, Juan de Dios; Anguiano, G; Segarra, M.; Rovira, Maria Josepa Salvadó; Ferré, Lluia Arola; Blay, Mayte

doi:10.1016/j.jnutbio.2005.06.005

Cited by 31 publications

(12 citation statements)

References 16 publications

(16 reference statements)

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“…This is largely in accordance with several other studies that reported similar results in rats and mice following ethanol and red wine consumption [4, 5, 11, 12]. Furthermore, for the first time, we showed that this holds true in both fast-growing younger animals and mature animals which were close to their body weight plateau.…”

Section: Discussionsupporting

confidence: 93%

“…Also, it appears that the type of alcoholic beverage is an important element in modifying the effect of alcohol consumption on weight gain with wine being regarded as an alcoholic beverage with more favourable effects [3]. Several animal studies, conducted under controlled experimental conditions, found that red wine intake did not cause an increase in body weight, compared to the water-only-drinking rats [4, 5]. Advantageous effects of wine were largely attributed to different biological actions of wine polyphenols.…”

Section: Introductionmentioning

confidence: 99%

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Effects of White Wine Consumption on Weight in Rats: Do Polyphenols Matter?

Milat

Mudnić

Grković

et al. 2017

Oxidative Medicine and Cellular Longevity

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Introduction Effects of white wine and the role of wine polyphenols on weight gain in rats of different age were examined in the 4-week-voluntary-consumption trial. Methods and Materials Biochemically characterized standard (low polyphenols, W) and macerated (high polyphenolic content, PW) white wines were compared. One- and three-month-old Sprague-Dawley male rats (n = 78) were used. Each age group was subdivided into water-only-drinking controls (C), W, and PW-drinking animals. Daily wine and total liquid consumption, food intake, and body weight were measured, and energy intake and feed efficiency index were calculated. Results In both age categories, wine-drinking animals consumed less food and gained less weight in comparison to C (181 ± 2, 179 ± 6, and 201 ± 5 in younger animals and 32 ± 5, 28 ± 6, and 47 ± 4 grams in older animals, resp.), regardless of wine type. Total energy intake was the lowest in PW-drinking animals. Conclusion Wine-drinking animals gained less weight in comparison to C, regardless of the wines' polyphenol content. Although our results are indicative of the major role of nonphenolic constituents of the wines (probably ethanol), the modifying role of wine phenolics on weight gain cannot be excluded as the group consuming PW had lower total energy intake than other groups.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Effects of White Wine Consumption on Weight in Rats: Do Polyphenols Matter?

Milat

Mudnić

Grković

et al. 2017

Oxidative Medicine and Cellular Longevity

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show abstract

“…Furthermore, recent data showed that voluntary red wine consumption prevented weight gain in rats fed a highfat diet. This effect was mediated through a decrease in energy intake [62]. The question of whether a specific component of red wine affects mechanisms of satiety has not yet been answered.…”

Section: Alcohol Consumptionmentioning

confidence: 99%

Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes

Schröder

2007

The Journal of Nutritional Biochemistry

289

217

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“…Given the role of leptin in maintaining body weight, this study was performed in both obese and non-obese animals. Additionally, numerous studies report the metabolic protective effects of grapes, grape by-products, cherries or their pure compounds 14 – 19 , and thus, we chose red grape and cherry as representative polyphenol-rich fruits for autumn and spring, respectively.…”

Section: Introductionmentioning

confidence: 99%

Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode

Ibars

Aragonès

Ardid-Ruiz

et al. 2018

Sci Rep

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Leptin has a central role in the maintenance of energy homeostasis, and its sensitivity is influenced by both the photoperiod and dietary polyphenols. The aim of this study was to investigate the effect of seasonal consumption of polyphenol-rich fruits on the hypothalamic leptin signaling system in non-obese and obese animals placed under different photoperiods. Non-obese and diet-induced obese male Fischer 344 rats were placed under either a short-day (SD) or long-day (LD) photoperiod and were supplemented with either 100 mg/kg of lyophilized red grapes or cherries. In non-obese animals, both fruits reduced energy balance independent of the photoperiod to which they were placed. However, the hypothalamic gene expression of Pomc was significantly up-regulated only in the SD photoperiod. In contrast, in obese animals only cherry significantly decreased the energy balance, although both fruits were able to counteract the diet-induced increase in hypothalamic AgRP mRNA levels when consumed during the SD photoperiod. In conclusion, the consumption of rich-polyphenol fruits may increase leptin sensitivity through the modulation of the hypothalamic leptin signal pathway mainly when consumed in the SD photoperiod. Therefore, fruit seasonality should be considered, as it can influence energy homeostasis and obesity.

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Moderate red-wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet☆

Cited by 31 publications

References 16 publications

Effects of White Wine Consumption on Weight in Rats: Do Polyphenols Matter?

Effects of White Wine Consumption on Weight in Rats: Do Polyphenols Matter?

Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes

Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode

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