Moderate or severe valvular heart disease and outcomes in allogeneic stem cell transplantation

Brusen, Robin; Cheng, Richard K.; Masri, S.C.; Leedy, Douglas; Sorror, Mohamed L.

doi:10.1016/j.ijcard.2019.05.032

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…Stem cells can be expanded and differentiated into specific target cells for replacing diseased or damaged tissues. Therefore, stem cells have been studied for cell therapies for diseases including spinal cord injuries [4], type 1 diabetes [5], Parkinson's disease [6], Alzheimer's disease [7], amyotrophic lateral sclerosis [8], burns [9], heart disease [10], stroke [11], cancer [12], and osteoarthritis [13]. However, obtaining enough numbers of appropriate stem cells has been challenging because of difficulties in isolating stem cells and ethical issues in using pluripotent embryotic stem cells [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells

Kim

Gil

Dayem

et al. 2020

JCM

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The availability of autologous adult stem cells is one of the essential prerequisites for human stem cell therapy. Urine-derived stem cells (USCs) are considered as desirable cell sources for cell therapy because donor-specific USCs are easily and non-invasively obtained from urine. Efficient isolation, expansion, and differentiation methods of USCs are necessary to increase their availability. Here, we developed a method for efficient isolation and expansion of USCs using Matrigel, and the rho-associated protein kinase (ROCK) inhibitor, Y-27632. The prepared USCs showed significantly enhanced migration, colony forming capacity, and differentiation into osteogenic or chondrogenic lineage. The USCs were successfully reprogramed into induced pluripotent stem cells (USC-iPSCs) and further differentiated into kidney organoid and hematopoietic progenitor cells (HPCs). Using flavonoid molecules, the isolation efficiency of USCs and the production of HPCs from the USC-iPSCs was increased. Taken together, we present an improved isolation method of USCs utilizing Matrigel, a ROCK inhibitor and flavonoids, and enhanced differentiation of USC-iPSC to HPC by flavonoids. These novel findings could significantly enhance the use of USCs and USC-iPSCs for stem cell research and further application in regenerative stem cell-based therapies.

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Section: Introductionmentioning

confidence: 99%

Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells

Kim

Gil

Dayem

et al. 2020

JCM

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Cardiovascular Issues in Hematopoietic Stem Cell Transplantation (HSCT)

López‐Fernández

Vadillo

Guía

et al. 2021

Curr. Treat. Options in Oncol.

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Cardiovascular Considerations in Patients Undergoing Hematopoietic Cell Transplantation

Hundal,

Curley,

Hamilton

2024

Curr. Treat. Options in Oncol.

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Opinion StatementCardiac dysfunction is a serious adverse effect of cancer therapies that can interfere with quality of life and impact long-term survival in patients with cancer. Hematopoietic cell transplantation is a potentially curative therapy for many advanced hematologic malignancies and bone marrow failure syndromes, however is associated with several short- and long-term adverse effects, including importantly, cardiovascular toxicities. The goal of this review article is to describe the cardiovascular events that may develop before, during, and after hematopoietic cell transplantation, review risk factors for short- and long-term cardiovascular toxicities, discuss approaches to cardiovascular risk stratification and evaluation, and highlight the research gaps in the consideration of cardiovascular disease in patients undergoing hematopoietic cell transplantation. Further understanding of cardiovascular events and the factors associated with cardiovascular disease will hopefully lead to novel interventions in managing and mitigating the significant long-term burden of late cardiovascular effects in transplant survivors.

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Moderate or severe valvular heart disease and outcomes in allogeneic stem cell transplantation

Cited by 4 publications

References 6 publications

Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells

Improved Isolation and Culture of Urine-Derived Stem Cells (USCs) and Enhanced Production of Immune Cells from the USC-Derived Induced Pluripotent Stem Cells

Cardiovascular Issues in Hematopoietic Stem Cell Transplantation (HSCT)

Cardiovascular Considerations in Patients Undergoing Hematopoietic Cell Transplantation

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