Moderate loading of the human osteoarthritic knee joint leads to lowering of intraarticular cartilage oligomeric matrix protein

Helmark, I. C.; Petersen, M. Christine H.; Christensen, H. E.; Kjær, Michael; Langberg, Henning

doi:10.1007/s00296-010-1716-7

Cited by 28 publications

(30 citation statements)

References 27 publications

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“…Levels were analyzed in the SF, serum, and urine after 30 minutes of exercise. A significant decrease in COMP concentration was observed in the SF following exercise, whereas aggrecan, CTX‐II, and IL‐6 remained unchanged compared to baseline . No differences in any of the markers were observed in serum or urine between baseline and post‐exercise.…”

Section: The Effects Of Exercise On Cartilage Bio‐composition In Humansmentioning

confidence: 75%

“…No differences in any of the markers were observed in serum or urine between baseline and post‐exercise. Based on this study, short term exercise probably induced movement facilitated transport of large COMP molecules from the intra‐articular space through the synovial membrane . It has been suggested that changes in COMP concentration within SF were not sufficient to result in any change at the whole body level.…”

Section: The Effects Of Exercise On Cartilage Bio‐composition In Humansmentioning

confidence: 99%

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Osteoarthritis biomarker responses and cartilage adaptation to exercise: A review of animal and human models

Mazor

Best

Césaro

et al. 2019

Scandinavian Med Sci Sports

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Regular physical activity has been suggested as having both preventive and therapeutic benefits for individuals with osteoarthritis (OA). However, evidence of whether exercise and which type of exercise constitutes a benefit or a risk in the development and progression of OA remains debatable. This may be due to the evaluation of the effect of physical activity or new disease‐modifying OA drugs which is currently based on radiographic criteria (eg, joint space width) and the lack of correlation with clinical signs and symptoms (eg, pain and loss of function). Moreover, OA typically manifests itself as changes within the joint space and subchondral bone as well as the whole joint structure, including progressive degradation of cartilage, menisci, ligaments, and synovial inflammation. Biomarkers are being developed to quantify joint remodeling and disease progression notably involving the articular cartilage and synovial fluid. The primary purpose of this review was to evaluate the current literature and to provide further insight based on OA biomarkers and the role physical activity plays in the management of OA. Osteoarthritis biomarkers together with radiographic imaging evidence will ideally guide healthcare providers to incorporate exercise recommendations into clinical management and offer patients evidence‐based and individually tailored exercise prescriptions.

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Section: The Effects Of Exercise On Cartilage Bio‐composition In Humansmentioning

confidence: 75%

Section: The Effects Of Exercise On Cartilage Bio‐composition In Humansmentioning

confidence: 99%

Osteoarthritis biomarker responses and cartilage adaptation to exercise: A review of animal and human models

Mazor

Best

Césaro

et al. 2019

Scandinavian Med Sci Sports

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“…COMP synthesis and release by chondrocytes is mechanically regulated (Piscoya et al, 2005; Wong et al, 1999) and has been shown to be elevated following canine meniscectomy, with peaks around 4 – 8 weeks after injury (Lindhorst et al, 2000). Previous studies have shown that 30 minutes of one-legged knee extension exercise decreases synovial fluid COMP in osteoarthritic knees (Helmark et al, 2012). Furthermore, the knee state and type of exercise impact alterations in COMP levels, as in healthy knees serum COMP levels correlate with cartilage volume changes after drop landing but not after running (Niehoff et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity

Carter

Taylor

Spritzer

et al. 2015

Journal of Biomechanics

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Meniscal tears are common injuries, and while partial meniscectomy is a frequent treatment option, general meniscus loss is a risk factor for the development of osteoarthritis. The goal of this study was to measure the in vivo tibiofemoral cartilage contact patterns in patients with meniscus tears in relation to biomarkers of cartilage catabolism in the synovial fluid of these joints. A combination of magnetic resonance imaging and biplanar fluoroscopy was used to determine the in vivo motion and cartilage contact mechanics of the knee. Subjects with isolated medial meniscus tears were analyzed while performing a quasi-static lunge, and the contralateral uninjured knee was used as a control. Synovial fluid was collected from the injured knee and matrix metalloproteinase (MMP) activity, sulfated glycosaminoglycan, cartilage oligomeric matrix protein, prostaglandin E2, and the collagen type II cleavage biomarker C2C were measured. Contact strain in the medial compartment increased significantly in the injured knees compared to contralateral control knees. In the lateral compartment, the contact strain in the injured knee was significantly increased only at the maximum flexion angle (105°). The average cartilage strain at maximum flexion positively correlated with total MMP activity in the synovial fluid. These findings show that meniscal injury leads to loss of normal joint function and increased strain of the articular cartilage, which correlated to elevated total MMP activity in the synovial fluid. The increased strain and total MMP activity may reflect, or potentially contribute to, the early development of osteoarthritis that is observed following meniscal injury.

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“…Thus, biomarkers from proteins in serum and synovium have recently been used to study changes in the knee osteoarthritis disease process. Furthermore, some recent studies have reported the effect of exercise interventions on circulating cartilage markers [26,27]. Exercises have shown to cause rise in circulating cartilage markers like cartilage oligomeric matrix protein (COMP), aggrecan and C-terminal telopeptides of collagen type II (CTX-II) [27,28].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, some recent studies have reported the effect of exercise interventions on circulating cartilage markers [26,27]. Exercises have shown to cause rise in circulating cartilage markers like cartilage oligomeric matrix protein (COMP), aggrecan and C-terminal telopeptides of collagen type II (CTX-II) [27,28]. Additionally, exercises have shown to increase the production of the anti-inflammatory mediator interleukin-10 [29].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of strength and aerobic exercise on patient-reported outcomes and structural changes in patients with knee osteoarthritis: study protocol for a randomized controlled trial

Øiestad

Østerås

Frobell

et al. 2013

BMC Musculoskelet Disord

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BackgroundDespite an extensive literature on treatment interventions for patients with knee osteoarthritis, studies comparing the efficacy of different exercise interventions and living the life as usual on quality of life, cartilage quality and cost-effectiveness are lacking. The aim of the present study is to compare the efficacy of two different exercise programs compared to a control group in individuals with established radiographic and symptomatic knee osteoarthritis on self-reported knee-related quality of life, knee pain, physical function, and cartilage quality.Methods/DesignA three-armed randomized controlled trial involving two exercise interventions and a control group of individuals doing as they usually do is described. The patients will have mild to moderate radiographic osteoarthritis according to the Kellgren and Lawrence classification (grade 2–3), and fulfill the American College of Rheumatology clinical criteria, be aged between 45 and 65 years, and have no other serious physical or mental illnesses. The patients will be randomly allocated to a strength exercise group; a cycling group, or a control group. The primary outcome is the Knee injury and Osteoarthritis Outcome Score knee-related quality of life subscale. Secondary outcomes include all five Knee Injury and Osteoarthritis Outcome Score subscales, morphological evaluation of cartilage including focal thickness, subchondral bone marrow edema, proteoglycan content and collagen degradation (measured using magnetic resonance imaging clinical sequences, T2 mapping and T1ρ), specific serum biomarkers, isokinetic muscle strength, maximal oxygen uptake, quality of life (EuroQol 5D), and self-efficacy (Arthritis Self-Efficacy Scale). A sample size calculation on the primary outcome showed that 207 individuals, 69 in each group, is needed to detect a clinically relevant difference of 10 points with 80% power and a significance level of 5%. Assessments will be conducted at baseline, 14 weeks, 1 year and 2 years post-randomization. The interventions will be a 14 weeks exercise program.DiscussionAlthough exercise therapy has been found to be effective in knee osteoarthritis, the knowledge of the underlying mechanisms for why exercise works is lacking. This study will contribute with knowledge on the efficacy of strength exercise versus cycling on patient-reported outcomes, cartilage quality and cost-effectiveness.Trial registrationClinicaltrial.gov Identifier: NCT01682980.

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Moderate loading of the human osteoarthritic knee joint leads to lowering of intraarticular cartilage oligomeric matrix protein

Cited by 28 publications

References 27 publications

Osteoarthritis biomarker responses and cartilage adaptation to exercise: A review of animal and human models

Osteoarthritis biomarker responses and cartilage adaptation to exercise: A review of animal and human models

In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity

Efficacy of strength and aerobic exercise on patient-reported outcomes and structural changes in patients with knee osteoarthritis: study protocol for a randomized controlled trial

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