Moderate-Intensity Ultrasound-Triggered On-Demand Analgesia Nanoplatforms for Postoperative Pain Management

Song, Xinye; Luan, Mengxiao; Zhang, Weiyi; Zhang, Ruizheng; Xue, Li; Luan, Yihui

doi:10.2147/ijn.s367190

Cited by 3 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, inertial cavitation could significantly avoid ROS production generated by sonodynamic therapy [56]. In addition, the inertial cavitation effect in the gas environment can dramatically reduce the power of ultrasound stimuli and stimuli-related subsidiary injury [57]. These data support that the cavitation effect enhanced mechanical effect may be more suitable for triggering levobupivacaine release during pain management.…”

Section: Discussionmentioning

confidence: 77%

Intensity-adjustable pain management with prolonged duration based on phase-transitional nanoparticles-assisted ultrasound imaging-guided nerve blockade

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background The lack of a satisfactory strategy for postoperative pain management significantly impairs the quality of life for many patients. However, existing nanoplatforms cannot provide a longer duration of nerve blockage with intensity-adjustable characteristics under imaging guidance for clinical applications. Results To overcome this challenge, we proposed a biocompatible nanoplatform that enables high-definition ultrasound imaging-guided, intensity-adjustable, and long-lasting analgesia in a postoperative pain management model in awake mice. The nanoplatform was constructed by incorporating perfluoropentane and levobupivacaine with red blood cell membranes decorated liposomes. The fabricated nanoplatform can achieve gas-producing and can finely escape from immune surveillance in vivo to maximize the anesthetic effect. The analgesia effect was assessed from both motor reactions and pain-related histological markers. The findings demonstrated that the duration of intensity-adjustable analgesia in our platform is more than 20 times longer than free levobupivacaine injection with pain relief for around 3 days straight. Moreover, the pain relief was strengthened by repeatable ultrasound irradiation to effectively manage postoperative pain in an intensity-adjustable manner. No apparent systemic and local tissue injury was detected under different treatments. Conclusion Our results suggest that nanoplatform can provide an effective strategy for ultrasound imaging-guided intensity-adjustable pain management with prolonged analgesia duration and show considerable transformation prospects.

show abstract

Section: Discussionmentioning

confidence: 77%

Intensity-adjustable pain management with prolonged duration based on phase-transitional nanoparticles-assisted ultrasound imaging-guided nerve blockade

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The application of nanotechnology can effectively reduce the side effects of pain medications and mitigate tolerance development, thereby improving treatment efficiency. Different pain drugs can be loaded onto various nanocarriers, including natural, synthetic, and copolymer nanocarriers, for different medical interventions ( Mendoza and Arruebo, 2020 ; Song et al, 2022 ). The development of nanotechnology has facilitated the emergence of pain relief strategies utilising various nanomaterials and targeted surface modifications.…”

Section: Introductionmentioning

confidence: 99%

Global research trends of nanotechnology for pain management

Zhu,

Yao,

Kuang

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Background: Nanotechnology has been increasingly used in healthcare during recent years. However, the systematic evaluation of research on nanotechnology for pain management is lacking. In this study, we employed a bibliometric approach to examine the status of the research and global trends of nanotechnology in relation to pain management.Methods: We selected relevant papers published in the Web of Science Core Collection database between 2013 and 2022 using search terms related to nanotechnology and pain management. Subsequently, the following bibliographic information was collected: publication year, originating country/region, affiliated authors and institutions, published journal, references cited, citation frequency, and keywords. The bibliometric software programs VOSViewer and CiteSpace were employed to obtain bibliometric statistics and perform visual analysis.Results: A total of 2680 papers were retrieved. The number of publications in the field of nanotechnology for pain management has been increasing annually since 2013. China had the highest number of published papers, whereas the United States led in total citations. The Chinese Academy of Sciences was the most prolific institution, while the Tehran University of Medical Sciences had the highest overall citations. Furthermore, De Paula was the most prolific author. Papers associated with nanotechnology for pain management were mainly published in the International Journal of Pharmaceutics, Pharmaceutics, and the International Journal of Nanomedicine. Keyword analysis showed that “in-vitro” and “drug-delivery” appeared most frequently, with the top 10 common keywords comprising nanoparticles, pain, in-vitro, drug-delivery, delivery, release, inflammation, neuropathic pain, formulation, and expression. Lastly, the latest emerging keyword was “electrochemical sensor”.Conclusion: Research on applying nanotechnology for pain management is growing steadily. China is the top country in terms of number of publications, with institutions under the Chinese Academy of Sciences making significant contributions to this field. “In-vitro” and “drug-delivery” are the current hotspots in this area, with “electrochemical sensor” as the latest topic at the research forefront. However, national and inter-institutional collaborations should be strengthened to enable patients with pain disorders to benefit from nanotechnology implementation in pain management.

show abstract