Moderate exercise training has anorexogenic effect associated with improved oxidative stress in obese women

Abstract

Endocrine derangement and oxidative stress are two distinguishing features of obesity that have limited the success rate of various management strategies, especially physical activities. The objective of the current study was to examine the effect of 8 weeks of moderate-intensity regular exercise training on oxidative stress, appetite and weight loss in obese women compared with normal-weight women. Sixteen normal-weight (body mass index (BMI) < 25 kg/m 2 ) and fifteen obese women (BMI > 30 kg/m 2 ) exercised on the bicycle ergometer at moderate intensity for 30 min, 3 times per week for 8 weeks. Blood samples were collected at the first day of training and 72 h after the completion of the training program which were then used for the measurement of F2-Isoprostanes, glutathione (GSH), oxidized glutathione (GSSG), leptin, adiponectin and nesfatin-1. Eight (8) weeks of training resulted in lower BMI, insulin, GSSG (P < 0.05), leptin (P < 0.01), and F2-Isoprostanes (P < 0.001) and higher nesfatin-1 levels (P < 0.01) relative to the levels at the pre-test stage in obese women. Also ∆leptin levels after exercise were positively correlated with ∆F2-Isoprostanes and ∆BMI. Eight weeks of moderateintensity regular exercise program did not only induce weight loss and improve oxidative stress, but also modified insulin, leptin and nesfatin-1 concentrations, particularly in obese women.

A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR

“…In accordance with our results, a negative correlation has been reported between nesfatin-1 and variables such as body fat percentage by a few previous studies (Tsuchiya et al, 2010;Mogharnasi et al, 2019b). In addition, it has been reported that 8 weeks of moderateintensity aerobic exercise diminished BMI and insulin and raised serum levels of nesfatin-1 in obese women (Nabil and El Sayyad, 2015). As noted in the literature, nesfatin-1 is highly sensitive to long-term training and significant loss of weight and fat percentage (Nabil and El Sayyad, 2015;Mogharnasi et al, 2019a).…”

“…In addition, it has been reported that 8 weeks of moderateintensity aerobic exercise diminished BMI and insulin and raised serum levels of nesfatin-1 in obese women (Nabil and El Sayyad, 2015). As noted in the literature, nesfatin-1 is highly sensitive to long-term training and significant loss of weight and fat percentage (Nabil and El Sayyad, 2015;Mogharnasi et al, 2019a).…”

Effects of physical activity and exercise on Nucleobindin‐2 gene expression and Nesfatin‐1 concentration: A rapid review

“…The purpose of conducting this review is to assess the existing research evidence regarding the impact of exercise on Nucleobindin-2 (NUCB2) gene expression and Nesfatin-From the 36 included studies, 23 examined humans with 13 examining animal models. [64][65][66][67][68][69][70][71][72][73][74][75][76] Studies investigated the effects of chronic exercise training [41][42][43][44][45][46][47][48][49][50][51]63 and acute exercise 48,[52][53][54][55][56][57][58][59][60][61][62] in humans.…”

“…Several studies have investigated the effect of endurance exercise training on Nesfatin-1 concentration in humans. 41,46,48,50,51,63 Ahmadizad et al investigated the effects of 6 weeks of highintensity interval training (HIIT: 3 days per week for 6 weeks) and moderate-intensity continuous exercise training (MICT: 3 days per week for 6 weeks) followed by a week of detraining on plasma Nesfatin-1 of physically inactive overweight men. They showed that plasma Nesfatin-1 only increased as a result of HIIT.…”

“…Eight weeks of moderate-intensity regular exercise program modified Nesfatin-1 concentrations, particularly in women living with obesity. 63 Some studies have investigated the effect of RT on Nesfatin-1 concentration in humans. 42,49 Mogharnasi et al investigated the effects of an 8-week upper-body RT (bench press, seated rows, sitting lat pulldown, arm extension, and arm curls; 3 sessions/week at a 60%-80% maximum amount of force) on Nesfatin-1 concentration in paraplegic men living with obesity.…”