Moderate exercise, postprandial lipaemia and triacylglycerol clearance

Gill, Jason M. R.; Mees, G; Frayn, Keith N.; Hardman, Adrianne E.

doi:10.1046/j.1365-2362.2001.00799.x

Cited by 82 publications

(72 citation statements)

References 34 publications

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“…In accordance with most of the relevant studies (Tsetsonis & Hardman, 1996a;Gill et al, 1998Gill et al, , 2001bHerd et al, 1998Herd et al, , 2001Malkova et al, 1999Malkova et al, , 2000, the postprandial response of total NEFA was not significantly different between exercise and control. This was also the case for the individual NEFA except for the ones most abundant in the test meal relative to plasma TG (ie, 16:1o7 and 20:1o9).…”

Section: Exercise and Lipemia After A Moderate Fat Meal M Kolifa Et Alsupporting

confidence: 88%

“…No difference was found in the insulinemic response either. The relevant literature is split in this respect, with some studies being in agreement with ours (Tsetsonis & Hardman, 1996a;Herd et al, 1998Herd et al, , 2001Malkova et al, 2000;Gill et al, 2001b;, some reporting significantly lower posprandial insulin AUC after exercise Malkova et al, 1999;Gill & Hardman, 2000;Gill et al, 2001a;, and some producing different outcomes for different exercise conditions or subject characteristics (Tsetsonis & Hardman, 1996b;Tsetsonis et al, 1997;Gill et al, 1998;Petitt et al, 2003). The insulinemic response in the present study was markedly higher than in the other studies due to the higher carbohydrate content of the test meal (2.14 vs 1.44 g/ kg at the most).…”

Section: Exercise and Lipemia After A Moderate Fat Meal M Kolifa Et Alsupporting

confidence: 86%

“…This hypothesis has been based on the fact that the attenuation of postprandial lipemia is observed within the time frame of enhanced LPL expression and activity after acute exercise (Seip & Semenkovich, 1998), but experimental evidence is either weak (Herd et al, 2001; or not supportive Gill et al, 2001b;Thomas et al, 2001). An alternative (or complementary) mechanism, decreased secretion of TG by the liver, has gained indirect experimental support Gill et al, 2001a).…”

Section: Introductionmentioning

confidence: 99%

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Effect of prior exercise on lipemia after a meal of moderate fat content

2004

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Objective: Prior exercise has been repeatedly shown to reduce lipemia after meals of exaggerated fat content (over 60% of total energy). The aim of the present study was to investigate whether the same applies to meals closer to the composition of the typical Western diet and explore whether exercise affects the release of dietary fat into the bloodstream. Design: Randomized counterbalanced. Setting: Laboratory. Subjects: Nine healthy young male volunteers. Intervention: Subjects consumed a meal of moderate fat content (35% of total energy, 0.66 g/kg body mass) 14 h after having either cycled for 1 h at 70-75% of maximal heart rate or rested. Macadamia nuts were used as the main source of dietary fat to trace its entry into the circulation because of their unusual fatty acid composition. Blood samples were drawn before the meal and for 8 h postprandially. Results: Plasma triacylglycerol concentrations and total area under the triacylglycerol concentration vs time curve (AUC) were significantly lower after exercise (P ¼ 0.001 and 0.003, respectively; effect size for the latter, 0.84). However, incremental (above baseline) AUC was not affected by exercise significantly. When controlling for differences in baseline plasma concentrations, only the fatty acids that were more abundant in the meal than in plasma triacylglycerols were decreased in the early postprandial period following exercise, implying either a suppressive effect of exercise on the rate of triacylglycerol release from the intestine or a more rapid chylomicron clearance after meal consumption. Conclusions: Exercise performed between 15 and 14 h before a meal of moderate fat content reduced postprandial lipemia, mainly by lowering fasting triacylglycerols. The effect of exercise on postprandial triacylglycerol metabolism may be mediated, at least in part, by attenuated release of dietary fat from the intestine.

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Section: Exercise and Lipemia After A Moderate Fat Meal M Kolifa Et Alsupporting

confidence: 88%

Section: Exercise and Lipemia After A Moderate Fat Meal M Kolifa Et Alsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Effect of prior exercise on lipemia after a meal of moderate fat content

2004

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“…The same exercise energy expenditure will attenuate postprandial lipemia to the same degree whether the exercise is performed in a single session or in multiple sessions 32) . It is also reported that an exercise-induced energy deficit induces a much greater reduction of postprandial lipemia than a dietary-induced energy deficit of the same magnitude, implying that the exercise-induced change of TG metabolism cannot be mimicked by simply reducing energy intake 33) . However, in the present study the effects of shortly preprandial exercise and postprandial exercise were surprisingly different in spite of the fact that they entailed the same energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

Hashimoto

Ootani

Hayashi

et al. 2011

JAT

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“…Other studies (17) have reported fasting triglyceride CVs of 22% in nondiabetic subjects. Because the intraindividual variation of triglyceride levels can be influenced by smoking, alcohol, and exercise (18,19), these were prohibited during and the day before the OTTT. Also, we found 2-h postchallenge glucose CVs of ϳ15 and ϳ8% in diabetic and nondiabetic subjects, respectively.…”

Section: Correlationsmentioning

confidence: 99%

A Standardized Triglyceride and Carbohydrate Challenge

Mohanlal

Holman

2004

Diabetes Care

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OBJECTIVE -A standardized method of assessing postprandial triglyceride changes is not available. We evaluated an oral triglyceride tolerance test (OTTT) designed for routine clinical and research use. RESEARCH DESIGN AND METHODS-A 200-ml strawberry-flavored test drink (50 g fat, 50 g carbohydrate) was administered twice to 30 diabetic and 20 nondiabetic subjects. Venous plasma triglyceride and glucose levels were measured when fasting and every 2 h for 8 h after the drink. Fingerprick plasma triglyceride levels were measured when fasting and at 6 and 8 h after the drink.RESULTS -The drink was consumed within 3 min and well tolerated by all subjects. The median triglyceride rise at 6 h was similar in diabetic and nondiabetic subjects (0.23 vs. 0.42 mmol/l, NS) and correlated with glucose increase at 2 h (r ϭ 0.429, P ϭ 0.018 and r ϭ 0.509, P ϭ 0.026; respectively). Diabetic subjects had higher 6-h geometric mean (1 SD range) triglyceride levels (1. CONCLUSIONS -The OTTT permits simple evaluation of postchallenge triglyceride levels, is acceptable to subjects, and can be performed with capillary sampling. It could be used to monitor triglyceride-lowering therapies and to provide additional information concerning cardiovascular disease risk, particularly in diabetic subjects. Diabetes Care 27:89 -94, 2004P eople with type 2 diabetes have a two-to fourfold increased risk of coronary heart disease (CHD) compared with the general population (1) that is only partly explained by the addition of hyperglycemia to traditional CHD risk factors (2). In diabetes, a mixed fasting dyslipidemia is common, characterized by an increased LDL-to-HDL cholesterol ratio, an increase in small dense LDL particles, and elevated triglyceride levels (3). Although fasting triglyceride levels may be an independent risk factor for CHD (4), their exact contribution remains uncertain because of displacement in most analyses by HDL cholesterol (2). This has led some authors to suggest that part of the excess CHD risk seen in type 2 diabetes may related more to postprandial rather than fasting triglyceride levels (5).In the absence of a standardized triglyceride challenge, studies to date have used a variety of different test meals consisting of "everyday" foods such as dairy products, bacon, margarine, and eggs or liquid formulations. These have contained various amounts of fat (33-66%; up to 110 g), carbohydrate (14 -43%; up to 75 g), and protein (16 -20%; up to 46 g) and, occasionally, have had vitamin A added (6 -11). To facilitate routine triglyceride tolerance assessment, we have formulated an easily produced and palatable 200-ml test drink. This oral triglyceride tolerance test (OTTT) has been evaluated in subjects with and without type 2 diabetes. In addition, the possibility of using capillary fingerprick samples as a simple alternative to venepuncture for use in the community or in large-scale studies has been investigated. RESEARCH DESIGN AND METHODS -The study was approved by the Central Oxford Research Ethics Committee (COREC). A tot...

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Moderate exercise, postprandial lipaemia and triacylglycerol clearance

Cited by 82 publications

References 34 publications

Effect of prior exercise on lipemia after a meal of moderate fat content

Effect of prior exercise on lipemia after a meal of moderate fat content

Acute Effects of Shortly Pre- Versus Postprandial Aerobic Exercise on Postprandial Lipoprotein Metabolism in Healthy but Sedentary Young Women

A Standardized Triglyceride and Carbohydrate Challenge

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