Moderate exercise may attenuate some aspects of immunosenescence

Drela, Nadzieja; Kozdroń, Ewa; Szczypiorski, Piotr

doi:10.1186/1471-2318-4-8

Cited by 72 publications

(57 citation statements)

References 37 publications

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“…Given the susceptibility of the elderly to bacterial pneumonia and the ability of moderate AE to modulate the immune system [12-16], the present study hypothesized that in PS-induced lung infection in elderly mice, low-intensity AE (running at 50% maximum speed for 60 min, 5 days a week for 5 weeks) increases bacterial clearance accompanied by attenuation of the proinflammatory cytokine and oxidative stress responses.…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice

et al. 2018

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Background: Pseudomonas aeruginosa (PS) infection results in severe morbidity and mortality, especially in immune-deficient populations. Aerobic exercise (AE) modulates the immune system, but its effects on the outcomes of pulmonary PS infection in elderly mice are unknown. Methods: BALB/c mice (24 weeks old) were randomized to sedentary, exercise (EX), PS, and PS + EX groups for the acute experimental setting, and PS and PS + EX groups for the chronic setting. Low-intensity AE was performed for 5 weeks, 60 min/day; 24 h after the final AE session, mice were inoculated with 5 × 10⁴ colony-forming units (CFU) of PS, and 24 h and 14 days after PS inoculation, mice were studied. Results: AE inhibited PS colonization (p < 0.001) and lung inflammation (total cells, neutrophils, lymphocytes [p < 0.01] in bronchoalveolar lavage [BAL]), with significant differences in BAL levels of IL-1β (p < 0.001), IL-6 (p < 0.01), CXCL1 (p < 0.001), and TNF-α (p < 0.001), as well as parenchymal neutrophils (p < 0.001). AE increased BAL levels of IL-10 and parenchymal (p < 0.001) and epithelial (p < 0.001) IL-10 expression, while epithelial (p < 0.001) and parenchymal (p < 0.001) NF-κB expression was decreased. AE diminished pulmonary lipid peroxidation (p < 0.001) and increased glutathione peroxidase (p < 0.01). Pre-incubation of BEAS-2B with IL-10 inhibited PS-induced epithelial cell expression of TNF-α (p < 0.05), CD40 (p < 0.01), and dichlorodihydrofluorescein diacetate (p < 0.05). Conclusions: AE inhibits PS-induced lung inflammation and bacterial colonization in elderly mice, involving IL-10/NF-κB, and redox signaling.

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Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice

et al. 2018

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“…Consequently, neuromuscular changes occur which may explain a reduction of muscle power, the motor decrease, functional dependence and the increase in disability and morbidity 8,9 . The habit of doing exercises on a regular basis has been suggested as one of the preventive methods for the muscular alterations that occur in the aging process [10][11][12][13][14] . However, there is no consensus about which exercise program is the best to increase muscle strength with regards to frequency, duration and intensity for elderly patients with frailty syndrome.…”

Section: Introductionmentioning

confidence: 99%

Efeito de um programa de resistência muscular na capacidade funcional e na força muscular dos extensores do joelho em idosas pré-frágeis da comunidade: ensaio clínico aleatorizado do tipo crossover

Lustosa

Silva²,

Coelho

et al. 2011

Rev. bras. fisioter.

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Impact of resistance exercise program on functional capacity and muscular strength of knee extensor in pre-frail community-dwelling older women: a randomized crossover trialEfeito de um programa de resistência muscular na capacidade funcional e na força muscular dos extensores do joelho em idosas pré-frágeis da comunidade: ensaio clínico aleatorizado do tipo crossover AbstractBackground: Frailty syndrome in elderly people is characterized by a reduction of energy reserves and also by a decreased of resistance to stressors, resulting in an increase of vulnerability. Objective: The aim of this study was to verify the effect of a muscle-strengthening program with load in pre-frail elder women with regards to the functional capacity, knee extensor muscle strength and their correlation.Methods: Thrity-two pre-frail community-dwelling women participated in this study. Potential participants with cognitive impairment (MEEM), lower extremities orthopedic surgery, fractures, inability to walk unaided, neurological diseases, acute inflammatory disease, tumor growth, regular physical activity and current use of immunomodulators were excluded. All partcipants were evaluated by a

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“…That has been shown by a Polish study, which examined elderly women undergoing moderate-intensity exercise. The results demonstrated that the percentage of lymphocytes expressing intracellular IL-2 was higher than sedentary control women, and it was the same for young women [13]. The intracellular IL-4-expressing lymphocytes have been decreased, thus contributing to control higher levels of memory cells than naïve cells [13].…”

Section: Physical Activity and Cytokinesmentioning

confidence: 84%

The role of exercise on the innate immunity of the elderly

Cristaldi

Vinci

Malaguarnera

2007

Eur Rev Aging Phys Act

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The increased life span in human population has shown that some diseases, as infections, cancer and autoimmune phenomena, occur more frequently in the elderly than in the younger. We describe the ageing process involving the innate immune system and the improvement given by moderate physical activity. In addition, we discuss the altered neutrophil granulocytes function, the role of macrophages and natural killer cells, besides the influence of cytokines and secretory IgA. The acquired information help us to explain how these changes could favor the onset of diseases in the elderly and how they may boost their immune function.

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Moderate exercise may attenuate some aspects of immunosenescence

Cited by 72 publications

References 37 publications

Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice

Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice

Efeito de um programa de resistência muscular na capacidade funcional e na força muscular dos extensores do joelho em idosas pré-frágeis da comunidade: ensaio clínico aleatorizado do tipo crossover

The role of exercise on the innate immunity of the elderly

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