Moderate Exercise Attenuates Lipopolysaccharide-Induced Inflammation and Associated Maternal and Fetal Morbidities in Pregnant Rats

Abstract

Fetal growth restriction (FGR) and coagulopathies are often associated with aberrant maternal inflammation. Moderate-intensity exercise during pregnancy has been shown to increase utero-placental blood flow and to enhance fetal nutrition as well as fetal and placental growth. Furthermore, exercise is known to reduce inflammation. To evaluate the effect of moderate-intensity exercise on inflammation associated with the development of maternal coagulopathies and FGR, Wistar rats were subjected to an exercise regime before and during pregnancy. To model inflammation-induced FGR, pregnant rats were administered daily intraperitoneal injections of E. coli lipopolysaccharide (LPS) on gestational days (GD) 13.5–16.5 and sacrificed at GD 17.5. Control rats were injected with saline. Maternal hemostasis was assessed by thromboelastography. Moderate-intensity exercise prevented LPS-mediated increases in white blood cell counts measured on GD 17.5 and improved maternal hemostasis profiles. Importantly, our data reveal that exercise prevented LPS-induced FGR. Moderate-intensity exercise initiated before and maintained during pregnancy may decrease the severity of maternal and perinatal complications associated with abnormal maternal inflammation.

Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry

“… 33 In contrast, daily moderate exercise attenuated systemic inflammation in response to lipopolysaccharide injection in mice. 34 Recently, Aqel, et al 35 demonstrated that daily moderate exercise improves the inflammatory response of LN in NZM2410/J mice through blocking the expression of inflammatory mediators IL-6, tumor necrosis factor-α, CXCL1, and anti-dsDNA antibodies. Their findings also implicated the possibility of adjunct therapeutic strategy for LN.…”

Influence of a Concurrent Exercise Training Program During Pregnancy on Colostrum and Mature Human Milk Inflammatory Markers: Findings From the GESTAFIT Project

“…There are several immune-protective components in human milk, including cytokines (Field, 2005; Goldman, Chheda, Garofalo, & Schmalstieg, 1996), that could affect the development and immunologic function of the neonate (Goldman et al, 1996). In this sense, maternal inflammation could be down-regulated by exercise during pregnancy (Kasawara et al, 2016; Tinius et al, 2016).…”

“…In this context, regular and moderate exercise might be a powerful intervention for reducing subclinical inflammation (Volpe et al, 2007). Moreover, it may in turn decrease the severity of maternal and perinatal complications associated with abnormal maternal inflammation (Kasawara et al, 2016). However, although exercise is well known to reduce systemic inflammation during pregnancy (Tinius, Cahill, Strand, & Cade, 2016), information regarding its influence on human milk markers is scarce or inexistent.…”

RNA binding protein, tristetraprolin in a murine model of recurrent pregnancy loss

“…Inflammation has been found to be closely linked with thrombotic events during fetal loss as well as fetal distress and indeed, both of the molecular pathways can directly influence the fetal health outcome [ 3 , 4 ]. LPS-induced inflammation during pregnancy has also been shown to increase maternal inflammation as well as thrombosis status [ 5 ].…”