Moderate ethanol ingestion, redox status, and cardiovascular system in the rat

Martín, Carmen González; Agapito, V Vega; Obeso, Ana; Prieto‐Lloret, Jesus; Bustamante, Rosa; Castañeda, Javier; Agapito, Teresa; González, C.

doi:10.1016/j.alcohol.2010.08.003

Cited by 11 publications

(6 citation statements)

References 44 publications

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“…A recent study indicates 1% ethanol intake in drinking water reduces the level of liver lipid peroxides (TBARS) in rats (6), although the parameters of liver injury are unaffected. The source of the discrepancy between the results of their study and our study is unknown.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of a Low Dose of Ethanol on Liver Function and Serum Urate in Rats Fed a High-Fat Diet

Osaki

Okazaki

Kimoto

et al. 2014

J Nutr Sci Vitaminol

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Summary This study investigated the effects of the consumption of 1% or 2% (v/v) ethanol in drinking water for 12 wk on rats fed a high-fat diet. Body weight gain, food intake, and fluid intake were unaffected by ethanol intake. Adipose tissue weight, and serum glucose and lipids were unaffected. Compared to the control (no ethanol), 1% ethanol intake significantly reduced serum levels of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ammonia (p,0.05), whereas 2% ethanol intake did so to a lesser extent. Serum urate was significantly lower in both the 1% and 2% ethanol groups than that in the control group (p,0.05). The results suggest a low dose of ethanol has beneficial effects on liver function and serum urate in rats fed a high-fat diet.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effect of a Low Dose of Ethanol on Liver Function and Serum Urate in Rats Fed a High-Fat Diet

Osaki

Okazaki

Kimoto

et al. 2014

J Nutr Sci Vitaminol

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“…Osaki et al reported that 1% ethanol intake revealed a J-curve effect and significantly reduced the serum levels of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ammonia as compared to the no-ethanol intake (18). In this study, the animals were provided free access to 1% ethanol through a drinking bottle as the moderate-alcohol dose based on the J-curve studies in rodents (18,22) and other studies (48,49).…”

Section: Introductionmentioning

confidence: 99%

“…Although numerous alcohol studies in rodents mainly focused on the responses to high alcohol doses, several studies have been conducted on moderate alcohol intake and healthy effects (15)(16)(17)(18)(19)(20)(21)(22). However, the relationship between moderate/sustained alcohol intake and health during a lifespan has been poorly studied.…”

Section: Introductionmentioning

confidence: 99%

Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

et al. 2016

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-Purpose: Heavy and long-term alcohol consumption increase the risk of alcohol-related diseases. Epidemiological studies show moderate drinking reduces the risk of mortality, cardiovascular diseases, and brain infarction in the J-shaped or U-shaped curve effect. However, why moderate drinkers may be healthy and non-drinkers may be ill in diverse populations remains controversial. Herein, we examined the relationship between moderate/lifelong alcohol intake and aging, especially aging-related cognitive functions in senescenceaccelerated mouse prone 8 (SAMP8) model. Methods: SAMP8 model (5-week-old, male, n = 36), a model of age-related cognitive deficit, were group-housed (n = 6/cage) and provided free access to water (water group, n = 18) or 1% ethanol (EtOH group, n = 18, intake started when mice were 9 weeks old). The object recognition test (ORT) and object location test (OLT) were used to evaluate cognitive functions. The intestinal flora at the age of 87 weeks was analyzed by terminal restriction fragment length polymorphism (T-RFLP). Results: The lifespan of the EtOH-group mice was about 4 weeks longer than that of the water-group mice. In the EtOH group, spatial recognition impairment, assessed by OLT, was observed later (age, 73 weeks) than that in the water group (age, 52 weeks). The spinal curvature and skin conditions progressed significantly slower in the EtOH group than in the water group. Moreover, diarrhea symptoms only appeared in the water group, at the age of 82 weeks. The T-RFLP analysis of the intestinal flora indicated higher Lactobacillales order and lower Clostridium cluster XI in the EtOH group than in the water group, although those were extremely high in some mice close to death in both groups. Water-group mice with diarrhea presented significantly higher Clostridium cluster XI than did those without diarrhea (P = 0.017). Conclusion: Moderate alcohol intake changes intestinal flora and positively affects aging of SAMP8 model.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

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“…[29]. Moreover, moderate consumption of alcohol reduced the activity of SOD and GPx [30,31]. Therefore, it is likely that the reduced activity of SOD may be associated with this reduced OR, although we have no data for the activity of antioxidative enzymes.…”

Section: Multiple Logistic Regression Analysis For Urinary H 2 Omentioning

confidence: 91%

Evaluation of urinary hydrogen peroxide as an oxidative stress biomarker in a healthy Japanese population

Sato

Oginö

Sakano

et al. 2013

Free Radical Research

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The usefulness of urinary hydrogen peroxide (H(2)O(2)) as an oxidative stress biomarker was evaluated in 766 healthy Japanese. The mean level of urinary concentrations of H(2)O(2) was 5.66 ± 8.27 μmol/g creatinine, and was significantly higher in females than in males. Significant correlations of H(2)O(2) were observed with age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), insulin, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and exercise habit in females. In both sexes, H(2)O(2) showed a significant correlation with 8-OHdG. By a multiple logistic regression analysis, urinary H(2)O(2) was positively associated with urinary 8-OHdG and TC and was inversely associated with insulin. By stratification of sex and age, the association of urinary H(2)O(2) with TC was positive in both sexes under 50 years old and was inverse in males over 50 years old, and that with insulin was inverse in males over 50 years old and in females under 50 years old. Moreover, by stratification of sex and age, a positive association of H(2)O(2) with exercise and an inverse association of H(2)O(2) with alcohol consumption became clear in males under 50 years old, although there were no significant odds for H(2)O(2) after adjustment for covariates. In conclusion, the present results suggest that urinary H(2)O(2) is a useful biomarker for oxidative stress, showing an association with 8-OHdG, TC, and insulin independently.

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Moderate ethanol ingestion, redox status, and cardiovascular system in the rat

Cited by 11 publications

References 44 publications

Beneficial Effect of a Low Dose of Ethanol on Liver Function and Serum Urate in Rats Fed a High-Fat Diet

Beneficial Effect of a Low Dose of Ethanol on Liver Function and Serum Urate in Rats Fed a High-Fat Diet

Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

Evaluation of urinary hydrogen peroxide as an oxidative stress biomarker in a healthy Japanese population

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