Moderate egg consumption and all-cause and specific-cause mortality in the Spanish European Prospective into Cancer and Nutrition (EPIC-Spain) study

Zamora-Ros, Raúl; Cayssials, Valerie; Clèries, Ramón; Redondo, María Luisa; Sánchez, María‐José; Rodríguez‐Barranco, Miguel; Sánchez-Cruz, José-Juan; Mokoroa, Olatz; Gil, Leire; Amiano, Pilar; Navarro, Carmen; Chirlaque, María Dolores; Huerta, José María; Barricarte, Aurelio; Ardanáz, Eva; Moreno‐Iribas, Conchi; Agudo, Antonio

doi:10.1007/s00394-018-1754-6

Cited by 29 publications

(45 citation statements)

References 27 publications

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“…The Japanese dietary pattern, Washoku, may be sufficient to avoid the influence of cholesterol by consumption of eggs. The correlation between consumption of eggs and cancer may also be a matter of concern, though not conclusive [162,163].…”

Section: Discussionmentioning

confidence: 99%

Nutritional Viewpoints on Eggs and Cholesterol

Sugano

Matsuoka²

2021

Foods

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Although most current epidemiologic studies indicate no significant association between consuming one egg daily and blood cholesterol levels and cardiovascular risk, arguments still persist with a positive association. Since the diet is one of the most influential factors for this association, we illustrate characteristic features in Japanese people whose dietary pattern is distinct from that, for example, the US (United States) population. Available epidemiologic studies in healthy Japanese people show no association between consumption of one egg daily and blood cholesterol level, consistent with those observed in the US population. However, when consumption of major nutrients and food sources of cholesterol are compared to the US population, Japanese people may have an extra-reserve against the influence of eggs on cardiovascular risk markers, despite consuming relatively more eggs. Further discussion on the influence of nutrients contained in the egg and dietary pattern, including interaction with gut microbes, is necessary. In addition, special consideration at the personalized level is needed for judgment regarding dietary cholesterol not only for hypercholesterolemic patients but for hyper-responsive healthy persons. Although randomized controlled trials with long-term follow-up are required to evaluate the association between consumption of eggs and human health, available information, at least from the nutritional viewpoint, suggests that egg is a healthy and cost-efficient food worldwide.

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Section: Discussionmentioning

confidence: 99%

Nutritional Viewpoints on Eggs and Cholesterol

Sugano

Matsuoka²

2021

Foods

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“…The Japan Collaborative Cohort Study found that consumption of fish showed a significant inverse association with HCC mortality among participants without history of liver diseases 43 . Studies on associations between eggs and prognosis of cancers were inconsistent 39,43,44 . Patients in this study had a low consumption of egg (1 g/day), far below the recommendation for eggs.…”

Section: Discussionmentioning

confidence: 65%

“…43 Studies on associations between eggs and prognosis of cancers were inconsistent. 39,43,44 Patients in this study had a low consumption of egg (1 g/day), far below the recommendation for eggs. At low egg intake levels, increasing egg consumption may provide high-quality protein and essential micronutrients for patients with HCC.…”

Section: Discussionmentioning

confidence: 68%

Association between dietary patterns and prognosis of hepatocellular carcinoma in the Guangdong liver cancer cohort study

Luo

Zhang

et al. 2020

Hepatology Research

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Adherence to dietary recommendations has been linked to a reduced risk of developing hepatocellular carcinoma (HCC) and dying of chronic liver disease. However, its role in the prognosis of HCC is still unclear. We prospectively investigated the association of two dietary quality indices, the Chinese Healthy Eating Index (CHEI) and the Healthy Eating Index 2015 (HEI 2015), with all cause and HCC specific mortality in a large prospective cohort of HCC survivors. Methods: We included 887 patients with newly diagnosed, previously untreated HCC enrolled in the Guangdong Liver Cancer Cohort (GLCC) between September 2013 and April 2017 in the analysis. CHEI and HEI 2015 scores were calculated based on the dietary intake in the year before diagnosis of HCC. Cox proportional hazards regression models were used to estimate multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for each index. Results: During a median follow up of 797 days, 389 deaths were identified, including 347 from HCC. Higher CHEI scores, reflecting favorable adherence to the 2016 Dietary Guidelines for Chinese, were associated with a lower risk of all cause mortality (T 3 vs. T 1 : HR=0.75, 95% CI: 0.58-0.98) and HCC specific mortality (T 3 vs. T 1 : HR=0.74, 95% CI: 0.56-0.98). Non significant, inverse associations of HEI 2015 score with all cause mortality (T 3 vs. T 1 : HR=0.86, 95% CI: 0.67-1.11) and HCC specific mortality (T 3 vs. T 1 : HR=0.93, 95% CI: 0.71-1.21) were suggested. Conclusions: Our findings suggest that better adherence to the 2016 Dietary Guidelines for Chinese may reduce the risk of all cause and HCC specific mortality in patients with HCC.

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“…Therefore, the question about the role of sex steroid hormones in milk in the development of prostate and testicular cancer in humans remains open. Additionally, high egg consumption is also associated with the occurrence of several cancers, including breast and prostate cancer [57], while there is no correlation between the consumption of up to one egg per day and any cause of mortality [58]. Although preventing cardiovascular disorders, a diet high in fi sh increases the risk of ovarian and endometrial cancer [59].…”

Section: Hormones In Food Of Animal Origin and Consumers' Healthmentioning

confidence: 99%

Hormones in Food as a Potential Risk for Human Reproductive and Health Disorders

Snoj

2019

Acta Veterinaria

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In the last 60 years, milk, meat, and egg worldwide consumption per capita increased 2-, 3-, and 5-fold, respectively. In the same period, several studies have reported a drop of semen quality and an increased incidence of cryptorchidism, hypospadias, and some hormone-related cancers (testicular, prostate, breast, endometrial cancer) in humans. A possible reason for these disruptions is increased exposure to exogenous hormones in food of animal origin. Hormones in food are considered to affect the endocrine system and cell signaling and thus disrupt homeostasis in the consumers. Since food safety assurance is a part of the veterinary service, the risk assessment of hormones in food as potential disruptive compounds is a significant challenge. Numerous cohort and epidemiologic studies and meta-analyses have been performed with respect to find an association between the consumption of food of animal origin and particular health disorders. Additionally, several studies in animal models have been performed to explain the mechanisms of disruptive effects of exogenous hormones. Since contradictory results have been reported, there is no general conclusion about the disruptive effects of exogenous hormones. Further experiments on animals in which long-term treatment with exogenous hormones is performed and further comprehensive endocrinological, toxicological, and human epidemiological studies are needed to confirm or deny the role of exogenous hormones in human health disorders. Moreover, long-term exposure to a combination of several exogenous compounds, such as environmental pollutants and dietary hormones and their additive effects, are also not well known and should be a topic for further studies.

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Moderate egg consumption and all-cause and specific-cause mortality in the Spanish European Prospective into Cancer and Nutrition (EPIC-Spain) study

Abstract: This study shows no association between moderate egg consumption, up to 1 egg per day, and main causes of mortality in a large free-living Mediterranean population.

Cited by 29 publications

References 27 publications

Nutritional Viewpoints on Eggs and Cholesterol

Nutritional Viewpoints on Eggs and Cholesterol

Association between dietary patterns and prognosis of hepatocellular carcinoma in the Guangdong liver cancer cohort study

Hormones in Food as a Potential Risk for Human Reproductive and Health Disorders

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