Moderate Alcohol Intake and Cancer Incidence in Women

Allen, Naomi E.; Beral, Valerie; Casabonne, Delphine; Kan, Sau Wan; Reeves, Gillian; Brown, Anna; Green, Jane

doi:10.1093/jnci/djn514

Cited by 505 publications

(451 citation statements)

References 40 publications

Supporting

Mentioning

412

Contrasting

Unclassified

Order By: Relevance

“…In consequence, the impact of a moderate level of alcohol consumption on breast cancer risk could not be clearly evaluated, unlike the case of previous studies. 57 However, our FFQ-based estimates of alcohol consumption have been validated repeatedly. 43,44 The study population in the current study tended to have a low prevalence of alcohol drinkers and this weakened the statistical power to detect the association.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption‐associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center‐based Prospective Study

Suzuki¹,

Iwasaki

Inoue³

et al. 2010

Intl Journal of Cancer

View full text Add to dashboard Cite

Epidemiological studies have evaluated whether the impact of alcohol intake on breast cancer risk is modified by use of exogenous estrogens, folate intake, body weight and smoking status, but results have been inconsistent. Further, effect modification by intake of isoflavones and alcohol-induced facial flushing, which are prevalent in Asian populations, have not been investigated. We investigated the association between alcohol intake and breast cancer risk and whether the association is modified by these factors among 50,757 premenopausal and postmenopausal women (aged 40-69 years) in the population-based Japan Public Health Center-based Prospective Study. Alcohol consumption and other related factors were assessed using self-reported questionnaires. Through to the end of 2006, 572 patients were identified. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated by hazard ratios derived from Cox proportional hazards regression models. Compared with never-drinkers, regular alcohol drinkers (>150 g of ethanol/week) had a higher risk of the development of breast cancer; the multivariable-adjusted RRs were 1.75 (95% CI 5 1.16-2.65; p trend 5 0.035) for overall, 1.78 (95% CI 5 1.09-2.90) for premenopausal and 1.21 (95% CI 5 0.53-2.75) for postmenopausal women. There was no statistical evidence for effect modification by menopausal status, use of exogenous estrogens, intakes of isoflavone and folate, body weight, alcohol-induced facial flushing or smoking (All p interactions ! 0.15). Excessive alcohol intake was associated with an increase in the risk of breast cancer in this population. There was no statistical evidence for effect modification.Alcohol-related carcinogenesis of the breast has been identified in a number of animal and epidemiological studies, and confirmed by the International Agency for Research on Cancer (IARC) working group, 1,2 the Second Expert Report from the World Cancer Research Fund, 3 and meta-analyses. 4,5 Apparently consistent with this, the steep increase in the incidence of breast cancer in Japan over the last 3 decades 6 has coincided with an upward trend in alcohol consumption, 7 although other explanations may include increased height, early menarche, low birthrate or late first birth. [8][9][10][11] Nevertheless, a recent qualitative review 12 of 11 epidemiological studies conducted in Japanese women suggested that the association remains inconclusive, albeit that one prospective study in 35,844 women, including 151 cases, reported a positive association. 13 Proposed mechanisms of ethanol-associated breast carcinogenesis include both hormone-dependent 14-19 as well as hormone-independent carcinogenic pathways, such as the induction of carcinogenesis, mutagenesis and DNA damage by acetaldehyde, a toxic ethanol metabolite; reactive oxygen species and an effect on one carbon metabolism, which is involved with folate level and vitamin B intake. [20][21][22][23][24] Although the results of a meta-analysis 5 supported both pathways by showing a positive association for estr...

show abstract

Section: Discussionmentioning

confidence: 99%

Alcohol consumption‐associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center‐based Prospective Study

Suzuki¹,

Iwasaki

Inoue³

et al. 2010

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…In our results the association was significantly larger among women who reported using HRT at baseline compared with non users. However, neither the Million Women Study [2] nor the EPIC-Europe study [41] found evidence of any interaction by HRT use and further studies using information about use over time are encouraged. We found no evidence of differences in the association by dietary folate intake or menopausal status.…”

Section: Discussionmentioning

confidence: 92%

“…The Million Women Study recently found a relative risk of 1.12 (95 % CI 1.09, 1.15) for a 10 g/day increase in alcohol intake based on 22,000 cases among drinkers [2]. Meta analyses have found combined OR or relative risk estimates per 10 g/day increase in alcohol intake of 1.09 (95 % CI 1.04, 1.13) [8], 1.071 (95 % CI 1.055, 1.087) [3], and 1.11 (95 % CI 1.05,1.15) [5].…”

Section: Discussionmentioning

confidence: 99%

“…Breast cancer is the most common type of cancer in women worldwide [1] and several large studies and meta-analyses have concluded that increased breast cancer risk is associated with higher alcohol intake [2][3][4][5][6][7][8][9][10][11][12]. Breast cancer has been added to the list of cancers for which there is convincing evidence of a causal relationship with alcohol consumption by the International Agency for Research on Cancer (IARC) [13] and World Cancer Research Fund/ American Institute for Cancer Research 2007 report [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estimating the alcohol–breast cancer association: a comparison of diet diaries, FFQs and combined measurements

et al. 2012

View full text Add to dashboard Cite

The alcohol-breast cancer association has been established using alcohol intake measurements from Food Frequency Questionnaires (FFQ). For some nutrients diet diary measurements are more highly correlated with true intake compared with FFQ measurements, but it is unknown whether this is true for alcohol. A case-control study (656 breast cancer cases, 1905 matched controls) was sampled from four cohorts in the UK Dietary Cohort Consortium. Alcohol intake was measured prospectively using FFQs and 4-or 7-day diet diaries. Both relied on fixed portion sizes allocated to given beverage types, but those used to obtain FFQ measurements were lower. FFQ measurements were therefore on average lower and to enable fair comparison the FFQ was ''calibrated'' using diet diary portion sizes. Diet diaries gave more zero measurements, demonstrating the challenge of distinguishing never-from episodic-consumers using short term instruments. To use all information, two combined measurements were calculated. The first is an average of the two measurements with special treatment of zeros. The second is the expected true intake given both measurements, calculated using a measurement error model. After confounder adjustment the odds ratio (OR) per 10 g/day of alcohol intake was 1.05 (95 % CI 0.98, 1.13) using diet diaries, and 1.13 (1.02, 1.24) using FFQs. The calibrated FFQ measurement and combined measurements 1 and 2

show abstract

“…They must have been able to be categorized in the ethnic groups of Asian/Pacific Islander, Non-Hispanic Black, Hispanic, and Non-Hispanic White. The geographic features included residents of California [3]. The temporal features span from January 1, 1995 to December 31, 2004.…”

Section: Samplingmentioning

confidence: 99%

Incidence and Mortality Rates of Oral Cancer in California from 1995-2004

Saini¹

2016

JDHODT

View full text Add to dashboard Cite

Moderate Alcohol Intake and Cancer Incidence in Women

Cited by 505 publications

References 40 publications

Alcohol consumption‐associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center‐based Prospective Study

Alcohol consumption‐associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center‐based Prospective Study

Estimating the alcohol–breast cancer association: a comparison of diet diaries, FFQs and combined measurements

Incidence and Mortality Rates of Oral Cancer in California from 1995-2004

Contact Info

Product

Resources

About