Moderate Alcohol Consumption Induces Lasting Impacts on Prefrontal Cortical Signaling in Mice
Grace C. Smith,
Keith R. Griffith,
Avery R. Sicher
et al.
Abstract:Both alcohol use disorder (AUD) and Alzheimer's Disease and Related Dementias (ADRD) appear to include disruption in the balance of excitation and inhibition in the cortex, but their potential interactions are unclear. We examined the effect of moderate voluntary binge alcohol consumption on the aged, pre-disease neuronal environment by measuring intrinsic excitability and spontaneous neurotransmission on prefrontal cortical pyramidal (excitatory, glutamatergic) and non-pyramidal (inhibitory, GABAergic) neuron… Show more
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