Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques

Messaoudi, Ilhem

doi:10.1016/j.alcohol.2013.09.024

Cited by 5 publications

(6 citation statements)

References 38 publications

(55 reference statements)

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“…Although the non-classical and intermediate monocytes fell into single clusters with equal numbers of cells from controls and CHD animals, differential gene expression analysis revealed significant downregulation of genes associated with MHC class II, antigen processing and presentation, and IFN signaling pathways in the CHD monocytes. This observation provides a potential explanation for the reduced response to vaccination observed in CHD animals (51). Indeed, monocytes from CHD animals generated a dampened cytokine and chemokine response to heat killed E.coli.…”

Section: Discussionmentioning

confidence: 87%

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

Lewis

Sureshchandra

Doratt

et al. 2021

Preprint

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Chronic heavy drinking (CHD) of alcohol is a known risk factor for increased susceptibility to bacterial and viral infection as well as impaired wound healing. Evidence suggests that these defects are mediated by a dysregulated inflammatory response originating from myeloid cells, notably monocytes and macrophages, but the mechanisms remain poorly understood. Our ability to study CHD is impacted by the complexities of human drinking patterns and behavior as well as comorbidities and confounding risk factors for patients with alcohol use disorders. To overcome these challenges, we utilize a translational rhesus macaque model of voluntary ethanol self-administration that closely recapitulates human drinking patterns and chronicity. In this study, we examined the effects of CHD on blood monocytes and alveolar macrophages in control and CHD female macaques after 12 months of daily ethanol consumption. While monocytes from CHD female macaques generated a hyper-inflammatory response to ex vivo LPS stimulation, their response to E.Coli was dampened. In depth scRNA-Seq analysis of purified monocytes revealed significant shifts in classical monocyte subsets with accumulation of cells expressing markers of hypoxia (HIF1A) and inflammation (NFkB signaling pathway) in CHD macaques. The increased presence of monocyte subsets poised to generate a hyperinflammatory response was confirmed by the epigenetic analysis which revealed higher accessibility of promoter regions that regulate genes involved in cytokine signaling pathways. Finally, alveolar macrophages (AM) from the same animals produced higher levels of inflammatory mediators in response to LPS stimulation, but reduced ability to phagocytose bacteria. Collectively, data presented in this manuscript demonstrate that CHD primes monocytes and tissue-resident macrophages towards a more hyper-inflammatory immune response with compromised functional abilities, which could be used in diagnostic purposes or preventative measures for patients with alcohol use disorders.

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Section: Discussionmentioning

confidence: 87%

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

Lewis

Sureshchandra

Doratt

et al. 2021

Preprint

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“…Moderate alcohol use may not weaken the immune response to a vaccine. In fact, moderate use may even increase responses: Rhesus monkeys that had moderate alcohol intake for 7 months had enhanced antibody and cell-mediated response to a booster shot, but those with long-term consumption of high levels of alcohol had weaker responses (Messaoudi et al, 2013). Research among humans similarly suggests that moderate alcohol use bolsters immune function: A greater number of alcoholic drinks (up to three or four per day) is associated with reduced risk of developing a cold upon exposure to the virus (Cohen et al, 1993).…”

Section: Health Behaviors Mattermentioning

confidence: 99%

Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19

Madison

Shrout

Renna

2021

Perspect Psychol Sci

147

114

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates are being evaluated, with the goal of conferring immunity on the highest percentage of people who receive the vaccine as possible. It is noteworthy that vaccine efficacy depends not only on the vaccine but also on characteristics of the vaccinated. Over the past 30 years, a series of studies has documented the impact of psychological factors on the immune system’s vaccine response. Robust evidence has demonstrated that stress, depression, loneliness, and poor health behaviors can impair the immune system’s response to vaccines, and this effect may be greatest in vulnerable groups such as the elderly. Psychological factors are also implicated in the prevalence and severity of vaccine-related side effects. These findings have generalized across many vaccine types and therefore may be relevant to the SARS-CoV-2 vaccine. In this review, we discuss these psychological and behavioral risk factors for poor vaccine responses, their relevance to the COVID-19 pandemic, as well as targeted psychological and behavioral interventions to boost vaccine efficacy and reduce side effects. Recent data suggest these psychological and behavioral risk factors are highly prevalent during the COVID-19 pandemic, but intervention research suggests that psychological and behavioral interventions can increase vaccine efficacy.

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“…Moderate alcohol use may not weaken the immune response to a vaccine. In fact, moderate use may even upregulate responses: rhesus monkeys that had a moderate alcohol intake for seven months had enhanced antibody and cell-mediated response to a booster shot, but those who chronically consumed high levels of alcohol had weaker responses (Messaoudi et al, 2013). Research among humans similarly suggests that moderate alcohol use bolsters immune function, as a greater number of alcoholic drinks (up to three or four per day) is associated with reduced risk of developing a cold upon exposure to the virus (Cohen, Tyrrell, Russell, Jarvis, & Smith, 1993).…”

Section: Alcohol Consumptionmentioning

confidence: 99%

Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19

Madison¹,

Shrout²,

Kiecolt‐Glaser³

2021

Preprint

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This review highlights key psychological and behavioral factors that can influence the immune system's response to a vaccine. The results generalize across a wide variety of vaccines, and therefore will likely be relevant to the SARS-COV-2 vaccine. Although the SARS-COV-2 vaccine candidates are highly efficacious, these psychological and behavioral factors can impact how long it takes to develop protective immunity as well as how long the protective immunity lasts. Importantly, even short-term psychological and behavioral interventions can boost the immune system's response to vaccination.

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Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques

Cited by 5 publications

References 38 publications

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

Transcriptional, epigenetic, and functional reprogramming of blood monocytes in non-human primates following chronic alcohol drinking

Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19

Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19

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