2017
DOI: 10.1093/nar/gkx054
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Models of global gene expression define major domains of cell type and tissue identity

Abstract: The current classification of cells in an organism is largely based on their anatomic and developmental origin. Cells types and tissues are traditionally classified into those that arise from the three embryonic germ layers, the ectoderm, mesoderm and endoderm, but this model does not take into account the organization of cell type-specific patterns of gene expression. Here, we present computational models for cell type and tissue specification derived from a collection of 921 RNA-sequencing samples from 272 d… Show more

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Cited by 53 publications
(82 citation statements)
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References 75 publications
(95 reference statements)
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“…We compared our data to a comprehensive atlas of murine cell types ( 26 ). We applied ICA to decompose expression of the atlas of cell types into 120 mutually independent components, and we correlated these to the components extracted from our single cell data (Fig.…”
Section: Methodsmentioning
confidence: 99%
See 4 more Smart Citations
“…We compared our data to a comprehensive atlas of murine cell types ( 26 ). We applied ICA to decompose expression of the atlas of cell types into 120 mutually independent components, and we correlated these to the components extracted from our single cell data (Fig.…”
Section: Methodsmentioning
confidence: 99%
“…We compared our data to a comprehensive atlas of murine cell types from( 26 ) that consists of uniformly re-analysed bulk and single cell RNA-seq data from 113 publications including 921 biological samples consisting of 272 distinct cell types.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations