1981
DOI: 10.1007/bf01870828
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Models of coupled salt and water transport across leaky epithelia

Abstract: A general formulation is presented for the verification of isotonic transport and for the assignment of a degree of osmotic coupling in any epithelial model. In particular, it is shown that the concentration of the transported fluid in the presence of exactly equal bathing media is, in general, not a sufficient calculation by which to decide the issue of isotonicity of transport. Within this framework, two epithelial models are considered: (1) A nonelectrolyte compartment model of the lateral intercellular spa… Show more

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Cited by 57 publications
(59 citation statements)
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“…The reflexion coefficient at the basal opening of the lateral intercellular space towards all solutes = 0. However, the diffusive barrier between the lateral intercellular space and submucosa is an important determinant of the capacity of the tissue to move water against a transepithelial salt concentration gradient (Weinstein & Stephenson, 1981). …”
Section: Discussionmentioning
confidence: 99%
“…The reflexion coefficient at the basal opening of the lateral intercellular space towards all solutes = 0. However, the diffusive barrier between the lateral intercellular space and submucosa is an important determinant of the capacity of the tissue to move water against a transepithelial salt concentration gradient (Weinstein & Stephenson, 1981). …”
Section: Discussionmentioning
confidence: 99%
“…JNa was calculated according to the rate of fluid absorption ([Na]*Jv), since the ratio of fluid and Na ϩ absorption is 1 in the proximal tubule (53). The JCl was calculated as JCl ϭ JNa Ϫ JHCO3 (see justification in DISCUSSION).…”
Section: Methodsmentioning
confidence: 99%
“…The JNa was calculated according to the rate of fluid absorption ([Na] * Jv), since the ratio of fluid and Na ϩ absorption is 1 in the proximal tubule (40). The JCl was estimated as JCl ϭ JNa Ϫ JHCO3.…”
Section: Methodsmentioning
confidence: 99%