Models for the mechanical characterization of core-shell microcapsules under uniaxial deformation

Huang, Yun-Han; Salmon, F. T.; Kamble, Abhijeet; Xu, April Xu; Michelon, Mariano; Leopércio, Bruna C.; Carvalho, Márcio S.; Frostad, John M.

doi:10.1016/j.foodhyd.2021.106762

Cited by 12 publications

(6 citation statements)

References 55 publications

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“…The point of contact between the rigid capillary and the neurospheres during static compression and the point at which contact is lost (separation) during decompression are not the same in a single run, and also change from one run to the next. To determine the point of contact in each case, we used the method suggested by Huang et al [ 33 ] with a slight modification to make the fitting routine more robust for our data. Specifically, a portion of the data is fit to the following function

y = {\begin{matrix} 0 & x < b^{2} \\ m {(x - b^{2})}^{1 + n^{2}} & x \geq b^{2} \end{matrix}

where y is the dependent variable (the force, in our case); x is the independent variable (the displacement or strain); and m , b , and n are adjustable parameters, with

b^{2}

corresponding to the point of contact.…”

Section: Resultsmentioning

confidence: 99%

The Mechanical Properties of Neurospheres

Okwara

Ghaemi

et al. 2021

Adv Eng Mater

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Stem cell‐derived 3D tissues such as spheroids are excellent models for investigating mechanisms of tissue formation and responses to physiological and mechanical cues. Neuronal spheroids, also known as neurospheres, have attracted particular interest. A lot is now known about the differentiation and maturation of neurospheres, as well as their responses to biochemical cues. However, understanding about their mechanical properties pales in comparison, which is all the more galling in light of newfound insights about how mechanical stimuli trigger the onset of neurodegenerative conditions. Herein, formative steps are taken to fill this knowledge gap. Neurospheres are generated from murine neural stem cells and are subjected to compressive forces. It is observed that neurospheres exhibit stress relaxation under static compression and viscoelastic behavior at low strains. The suitability of the Tatara model for characterizing the mechanical properties of neurospheres is also evaluated. The study is the first study of its kind to investigate the mechanical properties of in vitro 3D tissues. Moreover, the methodologies developed in the study can also be used to improve the quality and safety of cell and tissue biomanufacturing processes.

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y = {\begin{matrix} 0 & x < b^{2} \\ m {(x - b^{2})}^{1 + n^{2}} & x \geq b^{2} \end{matrix}

where y is the dependent variable (the force, in our case); x is the independent variable (the displacement or strain); and m , b , and n are adjustable parameters, with

b^{2}

corresponding to the point of contact.…”

Section: Resultsmentioning

confidence: 99%

The Mechanical Properties of Neurospheres

Okwara

Ghaemi

et al. 2021

Adv Eng Mater

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“…Generally, for polymeric capsule ν is supposed to be close to 0.5 for the sake of simplicity (see further). By fitting the experimental data using Equation ( 6), the elastic modulus can be measured reliably even for a liquid-core capsule [57]. For gellan gum microcapsules, this technique yields to measure the shell Young's modulus ranging from 10 kPa to 50 kPa, depending on the concentration of gellan gum [57].…”

Section: Compressionmentioning

confidence: 99%

“…By fitting the experimental data using Equation ( 6), the elastic modulus can be measured reliably even for a liquid-core capsule [57]. For gellan gum microcapsules, this technique yields to measure the shell Young's modulus ranging from 10 kPa to 50 kPa, depending on the concentration of gellan gum [57]. However, for large deformation a more sophisticated mechanical analysis has to be conducted.…”

Section: Compressionmentioning

confidence: 99%

Mechanical characterization of core-shell microcapsules

Xie¹,

Léonetti²

2023

Comptes Rendus. Mécanique

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Core-shell configurations are ubiquitous in nature such as in the form of bacterial and cells. Inspired by this, microcapsules are designed with actives as the cores surrounded by thin shells. They not only play an increasing role as artificial models for understanding dynamic behaviors of biological cells in flows, but are also becoming a fundamental class of artificial vehicles at the heart of drug delivery and release in applications. The mechanical properties of the shells are of great importance in this context. Here, we review recent experimental and theoretical characterizations of microcapsules, focusing on the soft and deformable particles with liquid cores. We begin by exploring the concept and fabrication of artificial microcapsules, followed by a discussion of different methods on the mechanical characterization of the shell.

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“…However, the concept of effective modulus of the microcapsule, or the overall stiffness, was only discussed in this work without consideration of the core‐shell geometry of microcapsules. In order to take account of this geometry in a large deformation regime, modified Reissner theory or core‐shell Tatara theory should be used instead 74 …”

Section: Mechanical Characterization Of Soft Microparticlesmentioning

confidence: 99%

“…In order to take account of this geometry in a large deformation regime, modified Reissner theory or coreshell Tatara theory should be used instead. 74…”

Section: Microelectromechanical Systemsmentioning

confidence: 99%

Mechanical characterization of soft microparticles prepared by droplet microfluidics

Kim

Lee

2022

Journal of Polymer Science

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Droplet microfluidics is one of the most promising approaches that allows preparation of microparticles with tailored structure and composition. Various functional microparticles have been developed using microfluidics, where their controlled structure shows high potential for a wide range of applications. Among these, soft polymeric microparticles which exhibit low elastic modulus compared to ceramics and metals are extensively investigated in biomedical applications due to their biocompatibility, high surface‐to‐volume ratio, as well as soft and deformable nature. As the mechanical properties of soft microparticles play important role in determining how they function in each application, it is essential to adequately characterize them for the optimal design of functional microparticles. In this review, we mainly discuss the mechanical characterization methods of soft microparticles and their elastic property. A brief overview of the droplet microfluidics‐assisted fabrication of microparticles is also provided before discussing the mechanical characterization techniques. We then describe the general characterization methods and models employed to determine the elastic properties of microparticles. In addition, we discuss the relationship between the physical parameters (size, composition, and structure) and the elastic properties of the microparticles, followed by the role of elastic properties in various applications including microcarrier, bioink, and self‐healing to name a few.

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Models for the mechanical characterization of core-shell microcapsules under uniaxial deformation

Cited by 12 publications

References 55 publications

The Mechanical Properties of Neurospheres

The Mechanical Properties of Neurospheres

Mechanical characterization of core-shell microcapsules

Mechanical characterization of soft microparticles prepared by droplet microfluidics

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