Models and finite element techniques for blood flow simulation

Behr, Marek; Arora, Dhruv; Coronado, Oscar M.; Pasquali, Matteo

doi:10.1080/10618560600789776

Cited by 17 publications

(11 citation statements)

References 30 publications

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“…An example of an alternative approach is the Deformable-Spatial-Domain/Stabilized Space-Time finite element formulation of Behr et al 63 which they used for calculating flow in the GYRO pump. They have implemented viscoelastic fluid modelling with blood as a viscoelastic fluid in a shear thinning solvent 64 and pressure head calculations agreed well with experimental measurements: calculations at most operating conditions were within 5 % of experiments but at the fastest speed the error was up to 12 %. While solution of the Navier-Stokes equations using mesh based methods are now commonly used for flows in VADs, there are a number of other ways to calculate fluid flows, including smoothed particle hydrodynamics 65, spectral methods 66 and the Lattice Boltzmann method 67.…”

Section: Computational Techniquesmentioning

confidence: 75%

The use of computational fluid dynamics in the development of ventricular assist devices

Fraser

Taşkın

Griffith

et al. 2011

Medical Engineering & Physics

227

236

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Progress in the field of prosthetic cardiovascular devices has significantly contributed to the rapid advancements in cardiac therapy during the last four decades. The concept of mechanical circulatory assistance was established with the first successful clinical use of heart-lung machines for cardiopulmonary bypass. Since then a variety of devices have been developed to replace or assist diseased components of the cardiovascular system. Ventricular assist devices (VADs) are basically mechanical pumps designed to augment or replace the function of one or more chambers of the failing heart.Computational Fluid Dynamics (CFD) is an attractive tool in the development process of VADs, allowing numerous different designs to be characterized for their functional performance virtually, for a wide range of operating conditions, without the physical device being fabricated. However, VADs operate in a flow regime which is traditionally difficult to simulate; the transitional region at the boundary of laminar and turbulent flow. Hence different methods have been used and the best approach is debatable. In addition to these fundamental fluid dynamic issues, blood consists of biological cells. Device-induced biological complications are a serious consequence of VAD use. The complications include blood damage (haemolysis, blood cell activation), thrombosis and emboli. Patients are required to take anticoagulation medication constantly which may cause bleeding. Despite many efforts blood damage models have still not been implemented satisfactorily into numerical analysis of VADs, which severely undermines the full potential of CFD. This paper reviews the current state of the art CFD for analysis of blood pumps, including a practical critical review of the studies to date, which should help device designers choose the most appropriate methods; a summary of blood damage models and the difficulties in implementing them into CFD; and current gaps in knowledge and areas for future work.

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Section: Computational Techniquesmentioning

confidence: 75%

The use of computational fluid dynamics in the development of ventricular assist devices

Fraser

Taşkın

Griffith

et al. 2011

Medical Engineering & Physics

227

236

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“…This re-design and comparison is a useful tool in engineering design. As an alternative technique, finite element analysis methods and related software are very useful tools to understand the mechanical damage of blood cell membranes [16], without any doubt these tools have key role to reduce the hemolysis problems for artificial surfaces in both in vivo and in vitro conditions in future.…”

Section: Resultsmentioning

confidence: 99%

Hemolysis in Medical Devices

Ostadfar¹

2017

IJBSBE

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Implantable assistive devices give hope of a permanent clinical solution to people with chronic failure, such as heart or kidney failures. While long-term use of continuous-blood flow is being researched, the eliminating the extreme level of blood damage in these devices is an important design challenge. Blood damage or hemolysis depends on exposure time and shear stress, and device designers have usually preferred design estimations and calculations rather than experimental studies to make a decision in their design. In this mini review, the hemolysis aspects are reviewed to explain the risk of blood cell damage in implantable artificial devices.

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“…XNS [3], a computational fluid dynamics application based on finite-element techniques on irregular three-dimensional meshes, serves as an example for a very substantial alteration of communication behavior. The code consists of roughly 45,000 lines of mixed Fortran and C in more than 100 files and has already been subject to performance analysis and subsequent optimization using the SCALASCA toolset [15].…”

Section: Altering Communication Behaviormentioning

confidence: 99%

Verifying Causality between Distant Performance Phenomena in Large-Scale MPI Applications

Hermanns

Geimer

Wolf

et al. 2009

2009 17th Euromicro International Conference on Parallel, Distributed and Network-Based Processing

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In message-passing applications, the temporal or spatial distance between cause and symptom of a performance problem constitutes a major difficulty in deriving helpful conclusions from performance data. So just knowing the locations of wait states in the program is often insufficient to understand the reason for their occurrence. We therefore present a method for verifying hypotheses on causal connections between temporally or spatially distant performance phenomena without altering the application itself. The verification is accomplished by modifying MPI event traces and using them to simulate the hypothetical message-passing behavior. By performing a parallel real-time reenactment of the communication to be simulated using the original execution configuration, we can achieve high scalability and satisfactory predictive accuracy in relation to the measured behavior. Not relying on a potentially complex model of the message-passing subsystem, our method is also platform independent.

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Models and finite element techniques for blood flow simulation

Cited by 17 publications

References 30 publications

The use of computational fluid dynamics in the development of ventricular assist devices

The use of computational fluid dynamics in the development of ventricular assist devices

Hemolysis in Medical Devices

Verifying Causality between Distant Performance Phenomena in Large-Scale MPI Applications

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