Modellreaktionen zur Synthese pharmakologisch aktiver Polymerer über monomere und polymere reaktive Ester

Batz, Hans‐Georg; Franzmann, Giselher; Ringsdorf, Helmut

doi:10.1002/ange.19720842410

Cited by 35 publications

(33 citation statements)

References 11 publications

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“…Early examples of highly ester-activated polymers were pioneered by Ferruti et al [93] and Ringsdorf et al [94]. Another interesting coupling approach was stressed by the group of Theato using monomers bearing activated esters, such as N-hydroxy succinimide esters or pentafluorophenyl esters, which can react in post-polymerization with primary and secondary amines functionalized with the desired moiety [95][96][97].…”

Section: Activated Esters As Precursor Of Post-polymerization Modificmentioning

confidence: 99%

Functional Polymers with Controlled Microstructure Based on Styrene and N ‐Substituted Maleimides

Chan‐Seng¹,

Zamfir²,

Lutz³

2012

Functional Polymers by Post‐Polymerization Modification

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Section: Activated Esters As Precursor Of Post-polymerization Modificmentioning

confidence: 99%

Functional Polymers with Controlled Microstructure Based on Styrene and N ‐Substituted Maleimides

Chan‐Seng¹,

Zamfir²,

Lutz³

2012

Functional Polymers by Post‐Polymerization Modification

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“…After evaporating the toluene, recrystallization out of ethanol yielded 85% of pure 4VBA as colorless needles. 1 Free Radical Polymerization of (4VBA) 1 4VBA and 2 mol-% of 2,2 0 -azobis(2,4-dimethyl-4-methoxy valeronitrile) were dissolved in approximately 0.5 ml of anhydrous THF for every 100 mg of 4VBA. The mixture was degassed by three freeze-thaw cycles and stirred under argon atmosphere for 16 h at 32 8C.…”

Section: Vbamentioning

confidence: 99%

“…The molecular weight distribution was obtained by GPC in THF. 1 H NMR (CDCl 3) : d ¼ 7.91-7.31 (m, br, 2H), 6.77-6.14 (m, br, 2H), 1.76-1.07 (m, br, 3H); GPC (THF):…”

Section: Vbamentioning

confidence: 99%

“…Thereby, the peak integration ratio of these two peaks represents the percentage of ethyl carbamate groups in the polymer. 1 to the carbamate for the reaction with ethanol under different conditions. The results are summarized in Table 1.…”

Section: Reactions On the Polymermentioning

confidence: 99%

“…[1] These reactive groups can then be converted into the respective functionality. As one possibility, the concept of active ester chemistry, which is well known from peptide synthesis, [2] was successfully applied to the synthesis of reactive prepolymers [3][4][5] and their reaction with nucleophiles.…”

Section: Introductionmentioning

confidence: 99%

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Poly(4‐vinylbenzoyl azide): A New Isocyanato Group Generating Polymer

Klinger

Chang

Théato

2007

Macromol. Rapid Commun.

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4‐Vinylbenzoyl azide was synthesized from p‐vinylbenzoic acid and polymerized by free radical polymerization. The obtained polymer contained acyl azide groups which were thermally transformed to the corresponding isocyanato groups. Reactions on these polymers with ethanol, hydroxyethyl methacrylate and 1‐pyrenebutanol proceeded quantitatively. Time‐resolved FT‐IR studies of the reactions with ethanol were carried out by varying the concentration and temperature. The effect of the solvent polarity on the Curtius rearrangement was investigated.

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Narrow Molecular Weight Distribution Precursors for Polymer-Drug Conjugates

et al. 2001

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Polymer ± drug conjugates derived from copolymers of N-(2-hydroxypropyl)-methacrylamide (HPMA) can be prepared from a copolymer precursor such as 3 (Scheme 1). [1] This methodology has been used for the development of conjugate 4 which is currently undergoing Phase II trials in the UK for the treatment of cancer. [2] To exploit more widely the biological advantages of large molecule therapeutics [1, 3a] and to examine more thoroughly how structure, molecular weight, [4] and solution properties correlate with biological profile [3] it is essential to develop preclinical conjugates that have 1) narrow molecular weight main transition at 531 nm and e 40 000 for the Q-like transition at 830 nm were recorded.[29] a) Crystallographic parameters for 6 (dark prisms grown from vapor diffusion of CH 2 Cl 2 and hexanes): orthorhombic, space group Pbcn, a 9.0295(2), b 17.1213(4), c 24.7737(6) , Z 4, R1 0.0365, wR2 0.0612, V 3829.9 3 . The data were collected on a Nonius Kappa CCD diffractometer using a graphite monochromator with Mo Ka radiation (l 0.71073 ) at À 150 8C using a Oxford Cryostream low temperature device. The structure was refined by fullmatrix least-squares on F 2 to 0.0612, with R(F) equal to 0.0242 and a GOF 1.009. The complex lies on a crystallographic twofold rotation axis at 0,y, 1 4. The twofold axis passes through the uranium atom and bisects the bipyrrole and the tetrapyrrole moieties. b) The crystallographic parameters for [Et 3 NH][7] (red-green dichromic rods, of dimension 0.08 Â 0.08 Â 0.12 mm 3 , were grown from vapor diffusion of CH 2 Cl 2 and hexanes): monoclinic, space group P2 1 /c, a 15.099 (2), b 22.742(3), c 14.353(1) , b 110.857(4)8, V 4606(1) 3 , Z 4, 1 calcd 1.501 mg m À3 . The data were collected at 203 K on a Bruker P4/ [*] Prof.

show abstract

Modellreaktionen zur Synthese pharmakologisch aktiver Polymerer über monomere und polymere reaktive Ester

Cited by 35 publications

References 11 publications

Functional Polymers with Controlled Microstructure Based on Styrene and N ‐Substituted Maleimides

Functional Polymers with Controlled Microstructure Based on Styrene and N ‐Substituted Maleimides

Poly(4‐vinylbenzoyl azide): A New Isocyanato Group Generating Polymer

Narrow Molecular Weight Distribution Precursors for Polymer-Drug Conjugates

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