Modelling the transmission dynamics of dengue in the presence of Wolbachia

Ndii, Meksianis Z.; Hickson, Roslyn I.; Allingham, David; Mercer, G. N.

doi:10.1016/j.mbs.2014.12.011

Cited by 90 publications

(70 citation statements)

References 43 publications

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“…Various models have been applied to try to understand the impact of Wolbachia on the transmission of dengue virus in its mosquito host (74)(75)(76). These models do not consider the effects of vertical transmission on the maintenance of dengue virus within a population, which has been suggested to be an important factor affecting the ability of the virus to persist within the population in rural areas with low human population densities (65).…”

Section: Figmentioning

confidence: 99%

Wolbachia-Mediated Antiviral Protection in Drosophila Larvae and Adults following Oral Infection

Stevanovic

Arnold

Johnson

2015

Appl Environ Microbiol

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Understanding viral dynamics in arthropods is of great importance when designing models to describe how viral spread can influence arthropod populations. The endosymbiotic bacterium Wolbachia spp., which is present in up to 40% of all insect species, has the ability to alter viral dynamics in both Drosophila spp. and mosquitoes, a feature that in mosquitoes may be utilized to limit spread of important arboviruses. To understand the potential effect of Wolbachia on viral dynamics in nature, it is important to consider the impact of natural routes of virus infection on Wolbachia antiviral effects. Using adult Drosophila strains, we show here that Drosophila-Wolbachia associations that have previously been shown to confer antiviral protection following systemic viral infection also confer protection against virus-induced mortality following oral exposure to Drosophila C virus in adults. Interestingly, a different pattern was observed when the same fly lines were challenged with the virus when still larvae. Analysis of the four Drosophila-Wolbachia associations that were protective in adults indicated that only the w1118-wMelPop association conferred protection in larvae following oral delivery of the virus. Analysis of Wolbachia density using quantitative PCR (qPCR) showed that a high Wolbachia density was congruent with antiviral protection in both adults and larvae. This study indicates that Wolbachia-mediated protection may vary between larval and adult stages of a given Wolbachia-host combination and that the variations in susceptibility by life stage correspond with Wolbachia density. The differences in the outcome of virus infection are likely to influence viral dynamics in Wolbachia-infected insect populations in nature and could also have important implications for the transmission of arboviruses in mosquito populations.A rthropods harbor a wide range of viruses that can be transmitted between individuals or populations of the same species or can bridge the interspecies gap to infect plants or other animals. The outcome of viral infections can be modulated by tripartite interactions between arthropods, viruses, and bacteria (1). One such interaction is the tripartite interaction between insects, viruses, and the endosymbyotic bacterium Wolbachia pipientis.Wolbachia spp. have gained much attention due to the antiviral effects they confer to their host. The impact of Wolbachia spp. on virus infection was first described in the Drosophila melanogaster host, where it was shown to protect against mortality induced by diverse viruses, including Drosophila C virus (DCV), cricket paralysis virus, and Flock House virus (2, 3). Since that discovery, Wolbachia-mediated antiviral effects have been demonstrated in a number of insect hosts and are being investigated as a way of limiting spread of arboviruses (reviewed in references 1, 4, 5, and 6). Notably, Wolbachia-mediated antiviral effects have been demonstrated in adult mosquitoes artificially infected with Wolbachia; in mosquitoes, Wolbachia can interfere with accu...

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Section: Figmentioning

confidence: 99%

Wolbachia-Mediated Antiviral Protection in Drosophila Larvae and Adults following Oral Infection

Stevanovic

Arnold

Johnson

2015

Appl Environ Microbiol

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“…Models for spatial dispersion are analyzed in [14] and [15]. In [16], [17], models are presented that assess the effect of the Wolbachia in dengue dynamics. [18] describes a data driven model suitable to estimate accurately some biological parameters by fitting the model with field and lab data.…”

Section: A Arboviroses and Vector Controlmentioning

confidence: 99%

Global stabilizing feedback law for a problem of biological control of mosquito-borne diseases

Bliman

Aronna

Coelho

et al. 2015

2015 54th IEEE Conference on Decision and Control (CDC)

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Abstract-The control of the spread of dengue fever by introduction of the intracellular parasitic bacterium Wolbachia in populations of the vector Aedes aegypti, is presently one of the most promising tools for eliminating dengue, in the absence of an efficient vaccine. The success of this operation requires locally careful planning to determine the adequate number of mosquitoes carrying the Wolbachia parasite that need to be introduced into the natural population. The latter are expected to eventually replace the Wolbachia-free population and guarantee permanent protection against the transmission of dengue to human.In this paper, we propose and analyze a model describing the fundamental aspects of the competition between mosquitoes carrying Wolbachia and mosquitoes free of the parasite. We then introduce a simple feedback control law to synthesize an introduction protocol, and prove that the population is guaranteed to converge to a stable equilibrium where the totality of mosquitoes carry Wolbachia. The techniques are based on the theory of monotone control systems, as developed after Angeli and Sontag. Due to bistability, the considered inputoutput system has multivalued static characteristics, but the existing results are unable to prove almost-global stabilization, and ad hoc analysis has to be conducted.

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“…The Wolbachia-infected mosquitoes are less able to transmit dengue, chikungunya, or Zika virus [2,10,12,14,16,32,34,39,56]. The goal of the modeling effort is to better understand how this bacterium can be used to control vector-borne diseases.…”

Section: Introductionmentioning

confidence: 99%

Two-sex mosquito model for the persistence ofWolbachia

Xue

Manore

Thongsripong

et al. 2016

Journal of Biological Dynamics

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We develop and analyse an ordinary differential equation model to investigate the transmission dynamics of releasing Wolbachiainfected mosquitoes to establish an endemic infection in a population of wild uninfected mosquitoes. Wolbachia is a genus of endosymbiotic bacteria that can infect mosquitoes and reduce their ability to transmit some viral mosquito-transmitted diseases, including dengue fever, chikungunya, and Zika. Although the bacterium is transmitted vertically from infected mothers to their offspring, it can be difficult to establish an endemic infection in a wild mosquito population. Our transmission model for the adult and aquatic-stage mosquitoes takes into account Wolbachia-induced fitness change and cytoplasmic incompatibility. We show that, for a wide range of realistic parameter values, the basic reproduction number, R 0 , is less than one. Hence, the epidemic will die out if only a few Wolbachiainfected mosquitoes are introduced into the wild population. Even though the basic reproduction number is less than one, an endemic Wolbachia infection can be established if a sufficient number of infected mosquitoes are released. This threshold effect is created by a backward bifurcation with three coexisting equilibria: a stable zeroinfection equilibrium, an intermediate-infection unstable endemic equilibrium, and a high-infection stable endemic equilibrium. We analyse the impact of reducing the wild mosquito population before introducing the infected mosquitoes and observed that the most effective approach to establish the infection in the wild is based on reducing mosquitoes in both the adult and aquatic stages. ARTICLE HISTORY

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Modelling the transmission dynamics of dengue in the presence of Wolbachia

Cited by 90 publications

References 43 publications

Wolbachia-Mediated Antiviral Protection in Drosophila Larvae and Adults following Oral Infection

Wolbachia-Mediated Antiviral Protection in Drosophila Larvae and Adults following Oral Infection

Global stabilizing feedback law for a problem of biological control of mosquito-borne diseases

Two-sex mosquito model for the persistence ofWolbachia

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