Modelling the topography of absolute defects in patients exposed to the anti-epileptic drug vigabatrin and in normal subjects using automated static suprathreshold perimetry of the entire 80° visual field

Besch, Dorothea; Schiefer, Ulrich; Eter, Nicole; Burth, R; Elger, Christian E.; Spitznas, Manfred; Dietz, Klaus

doi:10.1007/s00417-011-1625-9

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Thus, it was not recognized by patients as the temporal and inferior fields are often more important for the function. Besch and colleagues have observed sparing of the temporal field in VGB patients using static perimetry [26]. Nasal predominance of the VF constriction was also observed by Midlefart in regard to static perimetry within 60 degrees of eccentricity [6] and by Daneshvar [27].…”

Section: Discussionmentioning

confidence: 95%

Relationship between the area of isopters and Vigabatrin dosage during two years of observation

et al. 2014

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BackgroundThe aim of the study was to evaluate the relationship between the area of isopters obtained using semi-automated kinetic perimetry (SKP) and Vigabatrin dosage in epilepsy patients with pretreatment baseline examination during 2-years of the follow-up.Methods29 epilepsy patients were included into the study, but 15 individuals were excluded due to cognitive impairment, intracranial pathologies or eye diseases. Finally, 14 patients were examined with SKP before VGB treatment and after 6, 12, 18, and 24 months. Reaction time (RT)-corrected areas of three isopters (III4e, I4e and I2e) were measured for each of five examinations and compared intra-individually during 2-years period. Additionally, six epilepsy patients on other antiepileptic drugs were examined five times with SKP as a control.ResultsThere was a significant decrease of I2e, I4e and III4e isopters’ area during the follow-up of two years. Correlation was found between the I2e isopter’s area and both cumulative dose and mean daily dose of VGB. With increasing RT, there was decreasing of all isopters’ area in patients receiving VGB. In epilepsy patients who were not receiving VGB, there were no significance differences in isopters’ area during follow-up.ConclusionThere was attenuation of area of III4e, I4e and I2e isopters obtained with SKP during a period of 2 years. RT, the cumulative dose and the mean daily dose of VGB influenced isopters' area obtained with SKP.

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Section: Discussionmentioning

confidence: 95%

Relationship between the area of isopters and Vigabatrin dosage during two years of observation

et al. 2014

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Objective Derivation of the Morphology and Staging of Visual Field Loss Associated with Long-Term Vigabatrin Therapy

2019

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Background The morphology and between-eye symmetry of the visual field loss associated with the anti-epileptic drug vigabatrin (VAVFL) has received little attention. Objective To model the appearance, and ensuing staging, of VAVFL, derived with the European Medicines Agency approved perimetric protocol. Methods A retrospective, cross-sectional, observational design identified 123 adults who had received vigabatrin for refractory seizures and who had no evidence of coexisting retino-geniculo-cortical visual pathway abnormality. Thirty-eight adults with refractory seizures and identical inclusion criteria, but no exposure to vigabatrin, acted as controls. For each group, the median outcome at each stimulus location in each eye (of absolute loss, relative loss or Pattern Deviation probability level, as appropriate) was derived for each successive ten pairs of fields, ranked for severity. Between-eye symmetry was quantified by an index which accounted for severity of loss and which was referenced to the likelihood of the occurrence of symmetry due to chance. Results The modelled VAVFL was bilateral and highly symmetrical and was described by six stages which were all independent of the extent of vigabatrin exposure. The loss originated in the extreme temporal periphery and encroached centripetally along all meridians towards fixation. The initial appearance within the central field (Stage Two) occurred inferior-nasally. Subsequent stages exhibited increasing loss which was greater nasally than temporally. Stage Six described concentric loss extending to approximately 15° eccentricity from fixation. Conclusion The model exhibited a consistent pattern of VAVFL. The staging of the loss could assist the risk:benefit analysis of vigabatrin for the treatment of epilepsy.

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Drug-induced ocular side effects

2015

Drug-Induced Ocular Side Effects

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Modelling the topography of absolute defects in patients exposed to the anti-epileptic drug vigabatrin and in normal subjects using automated static suprathreshold perimetry of the entire 80° visual field

Cited by 4 publications

References 33 publications

Relationship between the area of isopters and Vigabatrin dosage during two years of observation

Relationship between the area of isopters and Vigabatrin dosage during two years of observation

Objective Derivation of the Morphology and Staging of Visual Field Loss Associated with Long-Term Vigabatrin Therapy

Drug-induced ocular side effects

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