Modelling the progression of a preleukemic stage to overt leukemia in children with Down syndrome

Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity

“…It was recently demonstrated that GM-CSF/CSF2 enhances survival in Down syndrome transient abnormal myelopoiesis (TAM), suggesting a growth advantage for ML-DS under GM-CSF/CSF2-rich conditions. 35 When CMK cells were injected into GS larvae, xenografts demonstrated increased cell proliferation at 3 dpi compared to casper controls ( Figure 2C , D). Strikingly, this was preceded by a sudden decrease in the number of CMK cells in both control and transgenic larvae at 2 dpi ( Figure 2D ).…”