Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Jouyban, Abolghasem; Martínez, Fleming

doi:10.15171/ps.2017.48

Cited by 3 publications

(2 citation statements)

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“…Importantly, it is a well-established leukogenic drug for treatment of leukopenia and thrombocytopenia. Various pharmacological activities of FA − stimulated many studies of its solubility, solvation behavior, and in vitro antitumor activity, and significant progress in understanding these properties has been achieved. ,− For example, Bitencourt et al measured the solubility of FA in supercritical carbon dioxide, ethanol, and water mixtures, and the solubility of FA in ternary and quaternary systems was estimated based on binary interaction parameters . Solubility measurements carried out by Shakeel et al suggest that the solubility of FA shows good solubilization potential in each neat organic solvent, namely, “methanol, ethanol, isopropanol, ethylene glycol, propylene glycol, 1-butanol, 2-butanol, ethyl acetate, dimethyl sulfoxide, polyethylene glycol-400, and Transcutol” except water .…”

Section: Introductionmentioning

confidence: 99%

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

et al. 2022

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The intermolecular interactions of ferulic acid (FA), a promising cancer-preventive agent, in mixed aqueous alcohol solutions were investigated using volumetric, viscometric, and refractive index approaches. The density and viscosity of aqueous ethanol/1-propanol solutions of FA were measured at different temperatures (293.15, 298.15, 303.15, 308.15, and 313.15 K) under atmospheric pressure using a digital liquid densimeter and an automatic rolling-ball microviscometer, respectively. The refractive index of aqueous ethanol/1-propanol solutions of FA was measured at 298.15 K using a refractometer. The apparent molar volumes and limiting partial molar volumes were calculated from the measured solution density values. The viscosity B-coefficients and their variation with temperature, that is, dB/dT, were obtained from the viscosity data. The molar refractions of FA were calculated from the refractive index measurements. In addition, the variation of these thermodynamic parameters with solution composition and temperature was analyzed in the light of the solute–solvent intermolecular interactions. The structure making/breaking ability of FA in the studied aqueous alcohol systems was investigated by studying the dB/dT dependence.

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Section: Introductionmentioning

confidence: 99%

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

et al. 2022

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“…From a therapeutical point of view, 2-propanol has also been investigated and proved for treatment of postoperative nausea or vomiting. 11 On the other hand, aqueous mixtures of 2-propanol have been analyzed in several studies of cosolvency and/or preferential solvation of some drugs and drug-alike compounds including trimethoprim, 12,13 ferulic acid, 14,15 celecoxib, 16 lamotrigine, 17 bosentan, 18 ketoconazole, 19 mesalazine, 20 5-nitrosalicylaldehyde, 21 uracil, 22 and lanosterol. 23 Physicochemical data regarding the equilibrium solubility of drug compounds in aqueous cosolvent mixtures, as well as the comprehension of the respective dissolution mechanisms, are very important in pharmaceutical and chemical sciences, because the measured, reported and analyzed solubility values expand the solubility database, which is useful for practical purposes in both the pharmaceutical and chemical industries.…”

Section: Introductionmentioning

confidence: 99%

Solubility, correlation, dissolution thermodynamics and preferential solvation of meloxicam in aqueous mixtures of 2-propanol

Tinjacá¹,

Martínez²,

Almanza³

et al. 2021

Pharm Sci

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Background: Meloxicam is a powerful analgesic and anti-inflammatory drug widely prescribed by physicians in current therapeutics. Because of the very low aqueous equilibrium solubility of meloxicam, this property has been studied in {2-propanol + water} mixtures from (293.15 to 313.15) K to expand the solubility database about pharmaceutical compounds in mixed solvents useful for homogeneous liquid dosage forms design. Methods: Flask shaken method and UV-vis spectrophotometry were used for meloxicam solubility determinations. Jouyban-Acree model was challenged for solubility correlation. The van’t Hoff and Gibbs equations were employed here to calculate the respective apparent standard thermodynamic quantities for the dissolution and mixing processes, namely Gibbs energy, enthalpy, and entropy. In addition, the inverse Kirkwood-Buff integrals were employed to compute the preferential solvation parameters of meloxicam by 2-propanol in the mixtures. Results: Meloxicam solubility increases with temperature arising and maximum solubilities are observed in the mixture of x1 = 0.70 at all temperatures. Jouyban-Acree model correlates the meloxicam solubility very well. Dissolution processes were endothermic in all cases and entropy-driven in the interval 0.20 ≤ x1 ≤ 1.00. Non-linear enthalpy–entropy relationship was observed in the plot of enthalpy vs. Gibbs energy exhibiting negative but variant slopes in the composition region 0.00 < x1 < 0.40 and variant negative and positive slopes in the other mixtures. Meloxicam is preferentially solvated by water in water-rich mixtures, it is apparently solvated by water in 2-propanol-rich mixtures, but it is preferentially solvated by 2-propanol in the composition interval of 0.19 < x1 < 0.78. Conclusion: Solid-liquid equilibrium of meloxicam in {2-propanol + water} mixtures has been studied at several temperatures as a contribution to preformulation studies of homogeneous liquid pharmaceutical dosage forms based on this drug.

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Solubility of lamotrigine in 2-propanol + water mixtures at T = (293.2 to 313.2) K

Rezaei

Jouyban

Barzegar-Jalali

et al. 2019

Journal of Molecular Liquids

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Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Cited by 3 publications

References 14 publications

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

Solubility, correlation, dissolution thermodynamics and preferential solvation of meloxicam in aqueous mixtures of 2-propanol

Solubility of lamotrigine in 2-propanol + water mixtures at T = (293.2 to 313.2) K

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Modelling the Preferential Solvation of Ferulic Acid in {2-Propanol (1) + Water (2)} Mixtures at 298.15 K

Cited by 3 publications

References 14 publications

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

Study on the Interactions of a Promising Cancer-Preventive Drug Ferulic Acid in Aqueous Ethanol/1-Propanol Solutions Using Volumetric, Viscometric, and Refractive Index Approaches

Solubility, correlation, dissolution thermodynamics and preferential solvation of meloxicam in aqueous mixtures of 2-propanol

Solubility of lamotrigine in 2-propanol + water mixtures at T = (293.2 to 313.2) K

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Solubility of lamotrigine in 2-propanol + water mixtures at T = (293.2 to 313.2) K