2011
DOI: 10.4137/becb.s7050
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Modelling the Molecular Transportation of Subcutaneously Injected Salubrinal

Abstract: For the subcutaneous administration of a chemical agent (salubrinal), we constructed a mathematical model of molecule transportation and subsequently evaluated the kinetics of diffusion, convection, and molecular turnover. Salubrinal is a potential therapeutic agent that can reduce cellular damage and death. The understanding of its temporal profiles in local tissue as well as in a whole body is important to develop a proper strategy for its administration. Here, the diffusion and convection kinetics was formu… Show more

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“…The delivery of a particle in this way is regulated by many factors such as particle size, interstitium properties, and hydrophobicity. Understanding the pharmacokinetics can therefore help clinicians to determine appropriate dosages and frequencies of drug administration (Chen et al 2011).…”
Section: Introductionmentioning
confidence: 99%
“…The delivery of a particle in this way is regulated by many factors such as particle size, interstitium properties, and hydrophobicity. Understanding the pharmacokinetics can therefore help clinicians to determine appropriate dosages and frequencies of drug administration (Chen et al 2011).…”
Section: Introductionmentioning
confidence: 99%