Modelling the Impact of NETosis During the Initial Stage of Systemic Lupus Erythematosus
Vladimira Suvandjieva,
Ivanka Tsacheva,
Marlene Santos
et al.
Abstract:The development of autoimmune diseases often takes years before clinical symptoms become detectable. We propose a mathematical model for the immune response during the initial stage of Systemic Lupus Erythematosus which models the process of aberrant apoptosis and activation of macrophages and neutrophils. NETosis is a type of cell death characterised by the release of neutrophil extracellular traps, or NETs, containing material from the neutrophil’s nucleus, in response to a pathogenic stimulus. This process … Show more
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