2023
DOI: 10.3390/pharmaceutics15020489
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Modelling the Evolution of Pore Structure during the Disintegration of Pharmaceutical Tablets

Abstract: Pharmaceutical tablet disintegration is a critical process for dissolving and enabling the absorption of the drug substance into the blood stream. The tablet disintegration process consists of multiple connected and interdependent mechanisms: liquid penetration, swelling, dissolution, and break-up. One key dependence is the dynamic change of the pore space in a tablet caused by the swelling of particles while the tablet takes up liquid. This study analysed the changes in the pore structure during disintegratio… Show more

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