Modelling the cyclic behaviour in a DTB crystallizer—a two-population balance model approach

Menon, Abhilash; Kramer, Herman J. M.; Grievink, Johan; Jansens, P.J.

doi:10.1016/j.jcrysgro.2004.11.211

Cited by 10 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This oscillating process behavior is a typical characteristic of an MSMPR crystallizer in which some form of activated nucleation is dominant. 65 The needlelike crystals were not observed for at least 12 residence times in the STC operated at a residence time of 2 h (STC-C06) (see Figures S45 and S46), unlike the case at a higher precipitant concentration (STC-C03). Furthermore, only the tetragonal form was obtained from the experiment performed in the STC at a residence time of 1 h (STC-C05) for at least 24 residence times of operation (see Figures S43 and S44).…”

Section: Influence Of Residence Timementioning

confidence: 97%

Continuous Protein Crystallization in Mixed-Suspension Mixed-Product-Removal Crystallizers

Thomas

Kwon

Lakerveld

2021

Crystal Growth & Design

View full text Add to dashboard Cite

The metastable needlelike form of lysozyme can be obtained from continuous crystallization in mixed-suspension mixed-product-removal (MSMPR) crystallizers for conditions at which the stable tetragonal form is obtained from batch crystallization. A 3D-printed airlift crystallizer and stirred tank crystallizer are used, which both approximate an MSMPR crystallizer well. The influence of residence time, precipitant concentration, and agitation mechanism on the attainable solid-state form is presented. The needlelike crystals appear after nucleation of the tetragonal form. An earlier transition from the tetragonal form to the needlelike form is observed in an airlift crystallizer compared to a conventional stirred crystallizer, which is possibly caused by reduced attrition and the presence of a gas–liquid interface in the airlift crystallizer. Furthermore, a long residence time and high precipitant concentration favor the formation of the needlelike crystals. This work demonstrates how the mode of operation of well-mixed crystallizers affects the attainable solid-state form of a model protein. The results generally show the importance of obtaining a quantitative understanding of the dynamic interplay between stochastic primary nucleation processes and deterministic growth and secondary nucleation processes so that future continuous MSMPR crystallizers can be designed and operated robustly to produce protein crystals of a desired solid-state form.

show abstract

Section: Influence Of Residence Timementioning

confidence: 97%

Continuous Protein Crystallization in Mixed-Suspension Mixed-Product-Removal Crystallizers

Thomas

Kwon

Lakerveld

2021

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…For modelling the evolution of a population of crystals during crystallisation processes, onedimensional (1D) population balance (PB) approach (e.g., (Alvarez and Myerson, 2010, Caillet et al, 2007, Garside, 1985, Gerstlauer et al, 2006, Hounslow et al, 2005, Li et al, 2013, Liu and Li, 2014, Menon et al, 2005, Patience et al, 2004, Rawlings et al, 1992, Temmel et al, 2016, Ulbert and Lakatos, 2005, Ward et al, 2006), using a characteristic size, such as length (e.g., (Vetter et al, 2014, Ward et al, 2011), diameter or radius of a volume equivalent sphere (e.g., ) to simplify a faceted crystal, was used and still being used widely. Two-dimensional (2D) PB method was developed to account for needle-/rod-/plate-like crystals (e.g., (Briesen, 2009, Gunawan et al, 2004, Ma et al, 2007, Oullion et al, 2007, Puel et al, 2003a, Puel et al, 2003b, Sato et al, 2008, Shi et al, 2006), whilst the introducing a volumetric shape factor into the 1D (or 2D) PB is to more accurately represent the crystal volume .…”

Section: S1 Mini-review Of Pb Modelsmentioning

confidence: 99%

Morphological population balance modelling of the effect of crystallisation environment on the evolution of crystal size and shape of para-aminobenzoic acid

Cai

2019

Computers & Chemical Engineering

View full text Add to dashboard Cite

show abstract

“…For a population of crystals (dissolving or crystallizing) in a crystallizer to manufacture pharmaceutical materials, the evolution of these crystals in terms of both size and shape is not well investigated using PB techniques. Traditionally, PB methods treat faceted crystals as their volume equivalent spheres with volume equivalent diameters (e.g., refs − , ), regardless of their actual shapes (cubic-like, plate-like, or needle-like...). Therefore, the shape information, hence face-specified properties, is lost by the simplification .…”

Section: Application Of Morphological Population Balance For Crystall...mentioning

confidence: 99%

“…Population balance (PB) modeling (for example, refs − ) has proved to be an excellent simulation tool for predicting the evolution of crystal size distributions for many practical processes. However, crystalline materials in their processing environment are inherently rarely spherical in terms of their external particle morphology.…”

Section: Introductionmentioning

confidence: 99%

Combining Morphological Population Balances with Face-Specific Growth Kinetics Data to Model and Predict the Crystallization Processes for Ibuprofen

2018

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

A route map for modelling pharmaceutical manufacturing processes utilising morphological population balance (MPB) is presented in terms of understanding and controlling of particle shape and size for optimising the efficiency of both the manufacturing process and final properties of the formulated drugs. This is applied to batch cooling crystallisation of the pharmaceutical compound, ibuprofen, from supersaturated ethanolic solutions in which the MPB is combined the known crystal morphology and associated face-specific growth kinetics (Nguyen et al., CrystEngComm, 2014, 16, 4568-4586) to predict the temporal evolution of the shape and size distributions of all crystals. The MPB simulations capture the temporal evolution of the size and shape of ibuprofen crystals and their distributions at each time instance during the crystallisation processes. The volume equivalent spherical diameter and crystal size distribution converted from MPB simulation are validated against the experimentally studies on the 1 litre scale size (Rashid et al., Chem Eng Res & Des, 2012, 90, 158-161), confirming the promise of this approach as a powerful simulation, optimisation and control tool for the digital design of precision pharmaceutical processes and products with the desirable properties, with potential applications in crystallisation design for personalised medicines.

show abstract

Modelling the cyclic behaviour in a DTB crystallizer—a two-population balance model approach

Cited by 10 publications

References 6 publications

Continuous Protein Crystallization in Mixed-Suspension Mixed-Product-Removal Crystallizers

Continuous Protein Crystallization in Mixed-Suspension Mixed-Product-Removal Crystallizers

Morphological population balance modelling of the effect of crystallisation environment on the evolution of crystal size and shape of para-aminobenzoic acid

Combining Morphological Population Balances with Face-Specific Growth Kinetics Data to Model and Predict the Crystallization Processes for Ibuprofen

Contact Info

Product

Resources

About