Modelling the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) by activated sludge and a pure culture

Almeida, Barbara; Oehmen, Adrian; Marques, Ricardo; Brito, Dulce; Carvalho, Gilda; Crespo, Maria Teresa Barreto

doi:10.1016/j.biortech.2013.01.035

Cited by 45 publications

(18 citation statements)

References 30 publications

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“…The biodegradation hypothesis is also further supported by secondary metabolites formation detected by UHPLC MS/MS. A similar conclusion was made by Almeida et al [44] who investigated the degradation of the NSAIDs mixture by the AS from three different WWTPs. Generally, the biodegradation kinetics in the bioaugmented assay AS1 and the non-bioaugmented AS2 followed a similar trend, especially for APAP, which was utilized with equal efficiency in both systems.…”

Section: Pharmaceuticals Removal and Secondary Metabolites Formationsupporting

confidence: 81%

“…In this study, we focused mainly on the metabolic response and biochemical diversity alterations in the AS during feeding with low concentrations of the drugs. As Almeida et al [44] reported, biodegradation is rarely studied in terms of the mixture of NSAIDs and analgesics, where synergistic effects of the presence of one drug on another are widely observed. It is well known that a combination of different compounds can affect biodegradation due to its inhibition or by competition and toxicity [44,45].…”

Section: The Impact Of Bioaugmentation and Pharmaceuticals On The As mentioning

confidence: 99%

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Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity

Żur

Michalska

Piński

et al. 2020

Water

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In this study, we evaluated the impact of the successive bioaugmentation of the activated sludge (AS) with the defined bacterial consortium on the activity and functional capacity of the AS microorganisms. In parallel, the removal of low concentrations of the selected non-steroidal anti-inflammatory drugs (ibuprofen, naproxen, diclofenac) and analgesic paracetamol was studied. We found that the addition of the bacterial consortium consisting of three pharmaceuticals-degrading strains Bacillus thuringiensis B1 (2015b), Stenotrophomonas maltophilia KB2, and Pseudomonas moorei KB4 into the AS did not cause any significant changes in the biomass abundance and metabolic activity of the AS microorganisms. Although, the successive bioaugmentation of the AS caused a slight increase in the metabolic diversity, the intensity of carbohydrates usage, and metabolic richness. Microorganisms in the bioaugmented and non-bioaugmented AS were able to degrade the mixture of the analyzed drugs with similar efficiency, however, diclofenac was removed more effectively in the bioaugmented AS. Several metabolites were identified and efficiently utilized, with the exception of 4-OH diclofenac. Two new diclofenac-degrading strains assigned as Serratia proteamaculans AS4 and Rahnella bruchi AS7 were isolated from the diclofenac-treated AS.

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Section: Pharmaceuticals Removal and Secondary Metabolites Formationsupporting

confidence: 81%

Section: The Impact Of Bioaugmentation and Pharmaceuticals On The As mentioning

confidence: 99%

Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity

Żur

Michalska

Piński

et al. 2020

Water

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“…Ketoprofen 2-(3-benzoylphenyl)propanoic acid is a type of PNSAID which has been detected in soil, surface water and in influents and effluents of wastewater treatment plants in concentrations ranging from ng l -1 up to lg l -1 (Xu et al 2009;Marco-Urrea et al 2010b;Almeida et al 2013). Adsorption and transformation of ketoprofen in soil are among the processes dependent on biotic and abiotic factors in soil.…”

Section: Biodegradation/biotransformation Of Ketoprofenmentioning

confidence: 99%

Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs

Domaradzka

Guzik

Wojcieszyńska

2015

Rev Environ Sci Biotechnol

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In recent years the increased use of polycyclic non-steroidal anti-inflammatory drugs has resulted in their presence in the environment. This in turn may cause potential negative effects on living organisms. While the biotransformation mechanisms of polycyclic non-steroidal anti-inflammatory drugs in the human body and in other mammals have been extensively studied, degradation of these drugs by microorganisms has seldom been investigated and is largely unknown. Biotransformation/biodegradation of polycyclic nonsteroidal anti-inflammatory drugs is caused by fungal microorganisms, mainly white-rot fungi, and a few strains of bacteria. However, hitherto only complete degradation of olsazine was described. The first step of the transformation is most often hydroxylation catalyzed by cytochrom P-450 monooxygenases, or oxygenation by laccases and three peroxidases: lignin peroxidase, manganese-dependent peroxidase and versatile peroxidase manganese-dependent peroxidase. The aim of this work is to summarize the knowledge about the biotransformation and/or biodegradation of polycyclic non-steroidal anti-inflammatory drugs and to present their biotransformation pathways.

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“…The microbial community is instrumental in determining the biological fate of PPCPs during water recycling (18), though little is known about the identity of key players in biotransformation of PPCPs in situ. The community can be affected by a number of environmental factors during SAT, including wetting and drying cycles of the soil during normal SAT operation.…”

mentioning

confidence: 99%

Removal of Pharmaceuticals and Personal Care Products during Water Recycling: Microbial Community Structure and Effects of Substrate Concentration

Onesios-Barry

Berry

Proescher

et al. 2014

Appl Environ Microbiol

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Many pharmaceuticals and personal care products (PPCPs) have been shown to be biotransformed in water treatment systems. However, little research exists on the effect of initial PPCP concentration on PPCP biotransformation or on the microbial communities treating impacted water. In this study, biological PPCP removal at various concentrations was assessed using laboratory columns inoculated with wastewater treatment plant effluent. Pyrosequencing was used to examine microbial communities in the columns and in soil from a soil aquifer treatment (SAT; a method of water treatment prior to reuse) site. Laboratory columns were supplied with different concentrations (0.25, 10, 100, or 1,000 g liter ؊1 ) of each of 15 PPCPs. Five PPCPs (4-isopropyl-3-methylphenol [biosol], p-chloro-m-xylenol, gemfibrozil, ketoprofen, and phenytoin) were not removed at any tested concentrations. Two PPCPs (naproxen and triclosan) exhibited removals independent of PPCP concentration. PPCP removal efficiencies were dependent on initial concentrations for biphenylol, p-chloro-m-cresol, chlorophene, diclofenac, 5-fluorouracil, ibuprofen, and valproic acid, showing that PPCP concentration can affect biotransformation. Biofilms from sand samples collected from the 0.25-and 10-g liter ؊1 PPCP columns were pyrosequenced along with SAT soil samples collected on three consecutive days of a wetting and drying cycle to enable comparison of these two communities exposed to PPCPs. SAT communities were similar to column communities in taxonomy and phylotype composition, and both were found to contain close relatives of known PPCP degraders. The efficiency of biological removal of PPCPs was found to be dependent on the concentration at which the contamination occurs for some, but not all, PPCPs.

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Modelling the biodegradation of non-steroidal anti-inflammatory drugs (NSAIDs) by activated sludge and a pure culture

Cited by 45 publications

References 30 publications

Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity

Effects of Low Concentration of Selected Analgesics and Successive Bioaugmentation of the Activated Sludge on Its Activity and Metabolic Diversity

Biodegradation and biotransformation of polycyclic non-steroidal anti-inflammatory drugs

Removal of Pharmaceuticals and Personal Care Products during Water Recycling: Microbial Community Structure and Effects of Substrate Concentration

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