Modelling skin wound healing angiogenesis: A review

Guerra, Ana; Belinha, J.; Jorge, R.M. Natal

doi:10.1016/j.jtbi.2018.09.020

Cited by 80 publications

(55 citation statements)

References 101 publications

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“…New blood vessels are formed during the proliferative phase to offer sufficient oxygen and nutrients amounts to the wound tissue and reestablish the blood flow 27 . Quantitative analysis of angiogenesis showed that aloe-alginate film promote an increase in the number of blood vessels on 14th day (p=0.005) following by a decrease on 21st (p=0.002) day compared to control.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride

et al. 2020

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Purpose To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions. Methods The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Wound contraction measurements and hystological analysis were performed on 7th, 14th and 21st days after wound surgery. Results The aloe-alginate film presented adequated mechanical resistance and malleability for application as wound dressing. There was no statistical difference in wound contraction between two groups. Histological assay demonstrated that aloe-alginate film presented anti-inflammatory activity, stimulated angiogenesis on proliferative phase and a more significant increased in collagen type I fibers and decreased type III fibers which promoted a mature scar formation when compared to control. Conclusions The aloe-alginate film showed adequate physicochemical characteristics for wound dressing applications. The in vivo assay demonstrated that aloe-alginate film enhanced the healing process of incisional skin wounds.

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Section: Discussionmentioning

confidence: 99%

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride

et al. 2020

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“…Among these mechanisms, angiogenesis plays a fundamental role in various physiological and pathological conditions, including wound healing and bone repair and regeneration, by reestablishing the normal blood flow and consequently the efflux of gases, nutrients, and growth factors [7,11,12]. Additionally, by regulating the viability, proliferation, and differentiation of newly developed tissue structures, angiogenesis represents a key element in tissue engineering and regenerative medicine applications [11,13].…”

Section: Introductionmentioning

confidence: 99%

“…In this manner, anti-angiogenesis-based therapies, which involve introducing agents to reduce blood vessel formation in malignant tumors or chronic diseases, have attracted great interest as potential anticancer treatments [11]. Therefore, the aim of this paper is to provide an overview of the mechanisms involved in physiological and pathological angiogenesis and the current state of anti-angiogenic therapies [7,12].…”

Section: Introductionmentioning

confidence: 99%

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

352

251

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Angiogenesis is the process through which novel blood vessels are formed from pre-existing ones and it is involved in both physiological and pathological processes of the body. Furthermore, tumor angiogenesis is a crucial factor associated with tumor growth, progression, and metastasis. In this manner, there has been a great interest in the development of anti-angiogenesis strategies that could inhibit tumor vascularization. Conventional approaches comprise the administration of anti-angiogenic drugs that target and block the activity of proangiogenic factors. However, as their efficacy is still a matter of debate, novel strategies have been focusing on combining anti-angiogenic agents with chemotherapy or immunotherapy. Moreover, nanotechnology has also been investigated for the potential of nanomaterials to target and release anti-angiogenic drugs at specific sites. The aim of this paper is to review the mechanisms involved in angiogenesis and tumor vascularization and provide an overview of the recent trends in anti-angiogenic strategies for cancer therapy.

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“…A ngiogenesis is an important process for tissue repair upon traumatic injuries and ischemic damages 1,2 . However, abnormal angiogenesis, also known as neovascularization (NV), causes diseases in the eye 3,4 .…”

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confidence: 99%

Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation

et al. 2020

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Angiogenesis is required for tissue repair; but abnormal angiogenesis or neovascularization (NV) causes diseases in the eye. The avascular status in the cornea is a prerequisite for corneal clarity and thought to be maintained by the equilibrium between proangiogenic and antiangiogenic factors that controls proliferation and migration of vascular endothelial cells (ECs) sprouting from the pericorneal plexus. VEGF is the most important intrinsic factor for angiogenesis; anti-VEGF therapies are available for treating ocular NV. However, the effectiveness of the therapies is limited because of VEGF-independent mechanism(s). We show that Zeb1 is an important factor promoting vascular EC proliferation and corneal NV; and a couple of small molecule inhibitors can evict Ctbp from the Zeb1-Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV. We conclude that Zeb1regulation of angiogenesis is independent of Vegf and that the ZEB1-CtBP inhibitors can be of potential therapeutic significance in treating corneal NV.

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Modelling skin wound healing angiogenesis: A review

Cited by 80 publications

References 101 publications

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

Zeb1 promotes corneal neovascularization by regulation of vascular endothelial cell proliferation

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