Modelling Renal Development and Disease in Drosophila

A specific isoform of Pyd/ZO-1 mediates junctional remodeling and formation of slit diaphragms

“…These discoveries allowed the use of nephrocytes to model kidney diseases. As a result, nephrocytes are a powerful tool to identify novel SD components and regulators and unravel the molecular mechanisms responsible for SD stability, damage, and repair (Carrasco-Rando et al, 2015; Na et al, 2015; Helmstädter et al, 2017).…”