“…On the contrary, extrinsic noise originates from the random variation of one or more of the externally set control parameters, e.g., the rate constants associated with a given set of reactions. In recent years, there has been a growing interest in the development of stochastic models for describing the behavior of intrinsic and extrinsic noise [2,14,18,29,31,33]. Basically, there are two types of genetic regulatory networks models, i.e., master equation and reactive-rate equation.…”