Modelling of the methyl halide biodegradation in bacteria and its effect on environmental systems

Bhatt, Pankaj; Pal, Kalyanbrata; Bhandari, Geeta; Barh, Anupam

doi:10.1016/j.pestbp.2019.04.015

Cited by 39 publications

(12 citation statements)

References 36 publications

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“…A microbial consortium performs better than axenic cultures due to robustness in metabolic function (Bhatt et al, 2019b). A mixed community of microorganisms can alleviate the metabolic limitations of a single population (Shong et al, 2012).…”

Section: Microbial Consortiummentioning

confidence: 99%

“…The systems biology of pesticide-degrading microbial cells is helpful for understanding the detailed metabolic pathways, lindane residues in the soil/water system and their effect on other living systems. Using this tool, we can analyze the overall biomagnification due to lindane in the environment (Bhatt et al, 2019b). Systems biology tools are also helpful to design the synthetic microbial consortium for the rapid removal of lindane from soil and water bodies.…”

Section: Novel Technologiesmentioning

confidence: 99%

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Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

et al. 2020

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Lindane (γ-hexachlorocyclohexane) is an organochlorine pesticide that has been widely used in agriculture over the last seven decades. The increasing residues of lindane in soil and water environments are toxic to humans and other organisms. Large-scale applications and residual toxicity in the environment require urgent lindane removal. Microbes, particularly Gram-negative bacteria, can transform lindane into non-toxic and environmentally safe metabolites. Aerobic and anaerobic microorganisms follow different metabolic pathways to degrade lindane. A variety of enzymes participate in lindane degradation pathways, including dehydrochlorinase (LinA), dehalogenase (LinB), dehydrogenase (LinC), and reductive dechlorinase (LinD). However, a limited number of reviews have been published regarding the biodegradation and bioremediation of lindane. This review summarizes the current knowledge regarding lindane-degrading microbes along with biodegradation mechanisms, metabolic pathways, and the microbial remediation of lindane-contaminated environments. The prospects of novel bioremediation technologies to provide insight between laboratory cultures and largescale applications are also discussed. This review provides a theoretical foundation and practical basis to use lindane-degrading microorganisms for bioremediation.

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Section: Microbial Consortiummentioning

confidence: 99%

Section: Novel Technologiesmentioning

confidence: 99%

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

et al. 2020

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“…The value for each molecular species ranges from 1 to 6.0 (S2 Table in S1 File ). The gene, protein, and mRNA values were set at 1.0 due to the basal amount in bacterial cells [ 21 ]. The agrochemical amounts were set at 0.5, 1.00, 1.5, 2.00, 3.00, and 4.00 and calculate the enzyme’s productivity on its products.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of methanolic extracts of Vernonia cinerea against Xanthomonas oryzae and identification of their compounds using in silico techniques

et al. 2021

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Bacterial Leaf Blight (BLB) disease is an extremely ruinous disease in rice, caused by Xanthomonas oryzae pv. oryzae (Xoo). Although various chemicals are available to manage BLB, they are toxic to the environment as well as humans. Hence there is a need to develop new pesticides as alternatives to hazardous chemicals. Therefore, a study was carried out to discover new potent natural pesticides against Xoo from different solvent extracts of Vernonia cinerea. Among all the fractions, the methanolic extract showed the highest inhibition zone. Further, to gain mechanistic insight of inhibitory action, 40 molecules of methanolic extracts were subjected for in silico study against two enzymes D-alanine—D-alanine ligase (Ddl) and Peptide deformylase (PDF). In silico study showed Rutin and Methanone, [1,4-dimethyl-7-(1- methylethyl)-2- azulenyl]phenyl have a good binding affinity with Ddl while Phenol, 2,4-bis(1-phenylethyl)- and 1,2-Benzenedicarboxylic acid, diisooctyl ester showed an excellent binding affinity to PDF. Finally, the system biology approach was applied to understand the agrochemical’s effect in the cell system of bacteria against both the enzymes. Conclusively, these four-hit compounds may have strong potential against Xoo and can be used as biopesticides in the future.

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“…Pesticides are organic compounds used in an enormous quantity in agriculture and homes to control a broad spectrum of pests [ 132 , 133 ]. Most pesticides are hydrophobic with complex structures.…”

Section: Glycoconjugates In Pesticide Degradationmentioning

confidence: 99%

Microbial glycoconjugates in organic pollutant bioremediation: recent advances and applications

et al. 2021

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The large-scale application of organic pollutants (OPs) has contaminated the air, soil, and water. Persistent OPs enter the food supply chain and create several hazardous effects on living systems. Thus, there is a need to manage the environmental levels of these toxicants. Microbial glycoconjugates pave the way for the enhanced degradation of these toxic pollutants from the environment. Microbial glycoconjugates increase the bioavailability of these OPs by reducing surface tension and creating a solvent interface. To date, very little emphasis has been given to the scope of glycoconjugates in the biodegradation of OPs. Glycoconjugates create a bridge between microbes and OPs, which helps to accelerate degradation through microbial metabolism. This review provides an in-depth overview of glycoconjugates, their role in biofilm formation, and their applications in the bioremediation of OP-contaminated environments.

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Modelling of the methyl halide biodegradation in bacteria and its effect on environmental systems

Cited by 39 publications

References 36 publications

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

Antimicrobial activity of methanolic extracts of Vernonia cinerea against Xanthomonas oryzae and identification of their compounds using in silico techniques

Microbial glycoconjugates in organic pollutant bioremediation: recent advances and applications

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