Modelling of systemic lesion of organism for development of multitarget cellular and cytokine therapy

Кордюм, В. А.; Chaikovsky, Yu. B.; Іродов, Д. М.; Drahulian, M. V.; Gulko, T. P.; Buchek, P. V.; Korsak, A.; Neverovskiy, A. V.

doi:10.7124/bc.000934

Cited by 3 publications

(5 citation statements)

References 14 publications

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“…The developed model of orbital trauma of the orbital allows to reproduce destructive changes in its content and deep degeneration of the optic nerve, which is consistent with the literature [Kordium et al 2016 response to trauma and axonal degeneration or death of retinal ganglion cells. In contrast, in group II animals after 12 and 24 weeks, although there was a decrease in the number of nerve fibers in the peripheral segment, however the growth of the gliocytes number was not so rapid, indicating less pronounced scarring and more successful regeneration.…”

Section: Discussionsupporting

confidence: 80%

Influence of the Neural Crest Derived Stem Cells to Optic Nerve Regeneration After Its Experimental Injury

2021

J. Diagn. Treat. Oral Maxillofac. Pathol.

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Purpose: Orbital trauma is a challenging problem due to such severe sequel as diplopia, decrease of vision or eye motility disorder. However, the conditions of orbital soft tissue content still become underestimated. The aim of this study was to investigate structural changes in the rat optic nerve after experimental injury followed by treatment with stem cells. Materials and Ьethods: An experimental model of injury to the orbital soft tissue content in the rat was developed. Forty Wistar rats maintained under daylight were divided into two equal experimental groups. Unlike the rats of Group I, in rats of Group II, the site of injury to the orbital soft tissue mass received postnatal multipotent stem cells, epidermal neural crest stem cells (NCSCs) derived from the bulge of hair follicles. Results: Comparing the number of glial cells per certain area of the slice (NC) between group І and site without injury (control) after 3 week of observation, it was higher in group I more than 258.8% (p < 0.0001) and on 272.4% in group II (p < 0.0001). After 6 weeks NC in group I was higher than at previous terms: more then 128.9% (р < 0.0001). At the same, NC in group II was higher comparing with previous terms only on 17.1% (р = 0.0212). Between the animals of group I at terms of 12 and 24 weeks NC high and wasn’t significantly differ between this terms of observation (ANOVA p = 0.4379). In contrast, NC in group II stopped rising between 6 and 12 weeks demonstrating statistical equality (p = 0.4563). Conclusions: It can be assumed that the application of mesenchymal stem cells, derivates of the neural crest, after the experimental orbital trauma, stimulates a recovery of the optic nerve. Further studies should be performed to more deeply discover the neural crest derived stem cell populations, ivoleved into recovery of damaged optic nerves.

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Section: Discussionsupporting

confidence: 80%

Influence of the Neural Crest Derived Stem Cells to Optic Nerve Regeneration After Its Experimental Injury

2021

J. Diagn. Treat. Oral Maxillofac. Pathol.

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“…The developed model of orbital trauma of the orbital allows reproducing destructive changes in its content and deep degeneration of the optic nerve, which is consistent with the literature. 11,1,7 According to the literature there are several major factors that complicate the regeneration of the optic nerve. On the one hand, trauma induces apoptosis of retinal ganglion neurons and there is a genetically determined weak ability of injured axons of mature retinal ganglion cells of the retina to regenerate.…”

Section: Discussionmentioning

confidence: 99%

“…7,6 Although numerous relevant studies have been conducted, and the pathogenesis of optic nerve damage has been thoroughly investigated, effective methods to promote regeneration of damaged optic nerve are still to be developed. 2,[8][9][10][11] Due to this, therapeutic influence to the regeneration of the nervous structures of the orbital soft tissue content could be recognized as appropriate component of complex orbital trauma management in addition to surgical reconstruction. However, treatment strategies capable of effecting major phases of the regenerative process should be developed.…”

Section: Introductionmentioning

confidence: 99%

August’s 2021 Full Issue PDF

2021

J. Diagn. Treat. Oral Maxillofac. Pathol.

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This is a monthly peer-reviewed oral and maxillofacial surgery journal focused on: Microvascular and jaw reconstructive surgery, dental implants, salivary gland tumors/diseases, TMJ lesions, virtual surgical planning, implementation of ultrasonography into the practice of oral and maxillofacial surgeons. Editorial Board (EB) CompositionEB shows significant geographic diversity representing 27 opinion leaders from 13 countries: Brazil,

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“…In the experiment we developed the model of systemic damage of a body with tetrachloromethane [4], based on reproducting of oxidative stress, which caused MOFS development in human [6], being accompanied by pathological changes in liver, lungs, kidneys and spleen [1,5].…”

mentioning

confidence: 99%

“…У експерименті розроблено модель системного ураження організмy тетрахлорметаном [4], яка грунтується на відтворенні оксидативного стресу, що викликає розвиток СПОН у людини [6] і супроводжується патологічними змінами печінки, легенів, нирок та селезінки [1,5].…”

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Spleen Morphological Features Under Experimental Model of Multiple Organ Failure and Stem Cell Application

Likhodiievskyi¹,

Korsak²,

Іродов³

et al. 2018

Probl Cryobiol Cryomed

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Modelling of systemic lesion of organism for development of multitarget cellular and cytokine therapy

Cited by 3 publications

References 14 publications

Influence of the Neural Crest Derived Stem Cells to Optic Nerve Regeneration After Its Experimental Injury

Influence of the Neural Crest Derived Stem Cells to Optic Nerve Regeneration After Its Experimental Injury

August’s 2021 Full Issue PDF

Spleen Morphological Features Under Experimental Model of Multiple Organ Failure and Stem Cell Application

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