Modelling of organ-specific radiation-induced secondary cancer risks following particle therapy

Stokkevåg, C.H.; Fukahori, Mai; Nomiya, Takuma; Matsufuji, Naruhiro; Engeseth, Grete May; Hysing, L.B.; Ytre-Hauge, Kristian S.; Rørvik, Eivind; Szostak, A.; Muren, L.P.

doi:10.1016/j.radonc.2016.07.001

Cited by 15 publications

(10 citation statements)

References 30 publications

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“…In general, there is considerable reluctance to apply CIRT for pediatric patients primarily out of concern regarding treatment-related adverse events and second malignant neoplasms [ 29 , 30 ]. While preclinical and modelling studies have reported conflicting results [ 31 – 34 ], the out-of-field dose from secondary neutrons is lowest for carbon ions delivered by scanning beams followed by protons delivered by scanning beams, then passive beams. Secondary neutrons dose was highest for high-energy photons [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Carbon ion radiotherapy for inoperable pediatric osteosarcoma

et al. 2018

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BackgroundUnresectable pediatric osteosarcoma has poor outcomes with conventional treatments.ResultsTwenty-six patients aged 11–20 years (median 16) had inoperable osteosarcoma of the trunk (24 pelvic, 1 mediastinal and 1 paravertebral) without any other lesion at initial examination. There were 22 primary, 1 locally recurrent and 3 metastatic cases. Median CIRT dose was 70.4 Gy RBE (relative biological effectiveness) delivered in 16 fractions. Median follow-up was 32.7 months. Overall survival was 50.0% and 41.7% at 3 and 5 years, respectively. Ten patients survived for more than 5 years (range 5–20.7 years). Local control was 69.9% and 62.9% at 3 and 5 years, respectively and progression-free survival was 34.6% at 3 and 5 years. Only largest tumor diameter correlated with 5-year overall survival and local control. There were 4 grade 3-4 CIRT-related late toxicities, 1 case of bone fracture and no treatment-related mortalities. All patients (except 1) were able to ambulate after CIRT.ConclusionsCIRT was safe and efficacious in the treatment of inoperable pediatric osteosarcoma with improved local control and overall survival compared to conventional treatments.MethodsWe retrospectively reviewed the records of pediatric and adolescent patients who received carbon ion radiotherapy (CIRT) for inoperable osteosarcoma between 1996 and 2014.

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Section: Discussionmentioning

confidence: 99%

Carbon ion radiotherapy for inoperable pediatric osteosarcoma

et al. 2018

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“…Since the NTCP parameters for both the rectum and bladder have low n values (suggesting a low volume effect), the influence of the RBE models on the NTCP should be larger for prostate cancer patients than it would for tumor sites where, e.g., the lung (that has an n value close to 1) is the critical normal tissue; for the lung, the NTCP correlates with the mean dose and may therefore be less influenced by the differences between the constant and variable RBE w doses. In order to further investigate the uncertainties in the parameters, and their influence on the RBE w dose, one option would be to perform a model parameter scan to identify the influence of these variations [26].…”

Section: Discussionmentioning

confidence: 99%

Biological dose and complication probabilities for the rectum and bladder based on linear energy transfer distributions in spot scanning proton therapy of prostate cancer

et al. 2017

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“…Due to the high uncertainty on the shape of the dose-response curve, it is hard to develop realistic mathematical models of radiation carcinogenesis. Comparative model studies of second cancer risk in patients exposed to C-ions and volumetric arc radiotherapy [ 312 ] or proton therapy [ 313 ] show only small predicted changes, that can change for different patients.…”

Section: Molecular Radiobiologymentioning

confidence: 99%

Carbon Ion Radiobiology

Tinganelli

Durante

2020

Cancers

129

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Radiotherapy using accelerated charged particles is rapidly growing worldwide. About 85% of the cancer patients receiving particle therapy are irradiated with protons, which have physical advantages compared to X-rays but a similar biological response. In addition to the ballistic advantages, heavy ions present specific radiobiological features that can make them attractive for treating radioresistant, hypoxic tumors. An ideal heavy ion should have lower toxicity in the entrance channel (normal tissue) and be exquisitely effective in the target region (tumor). Carbon ions have been chosen because they represent the best combination in this direction. Normal tissue toxicities and second cancer risk are similar to those observed in conventional radiotherapy. In the target region, they have increased relative biological effectiveness and a reduced oxygen enhancement ratio compared to X-rays. Some radiobiological properties of densely ionizing carbon ions are so distinct from X-rays and protons that they can be considered as a different “drug” in oncology, and may elicit favorable responses such as an increased immune response and reduced angiogenesis and metastatic potential. The radiobiological properties of carbon ions should guide patient selection and treatment protocols to achieve optimal clinical results.

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Modelling of organ-specific radiation-induced secondary cancer risks following particle therapy

Cited by 15 publications

References 30 publications

Carbon ion radiotherapy for inoperable pediatric osteosarcoma

Carbon ion radiotherapy for inoperable pediatric osteosarcoma

Biological dose and complication probabilities for the rectum and bladder based on linear energy transfer distributions in spot scanning proton therapy of prostate cancer

Carbon Ion Radiobiology

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