Modelling of magnetoimpedance response of thin film sensitive element in the presence of ferrogel: Next step toward development of biosensor for in-tissue embedded magnetic nanoparticles detection

Buznikov, N. A.; Сафронов, А. П.; Orúe, I.; Голубева, Е. В.; Lepalovskij, V. N.; Svalov, A. V.; Членова, А. А.; Kurlyandskaya, G. V.

doi:10.1016/j.bios.2018.06.032

Cited by 64 publications

(68 citation statements)

References 43 publications

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“…The first level of biocompatibility understanding is its estimation in the case of water based stable suspensions of the MNPs. In this respect, the LTE MNPs used in the present study serve as a very good model, as their physical and chemical properties were extensively tested in our previous studies [62,63], including hyperthermia studies and biological tests with different cell cultures [49,64,65]. Zhang et al [55] discussed diverse mechanical force-triggered drug delivery systems and, among others, an interesting case of release by deformation of carriers under compression.…”

Section: Discussionmentioning

confidence: 99%

The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties

et al. 2019

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Iron oxide γ-Fe2O3 magnetic nanoparticles (MNPs) were fabricated by laser target evaporation technique (LTE) and their structure and magnetic properties were studied. Polyacrylamide (PAAm) gels with different cross-linking density of the polymer network and polyacrylamide-based ferrogel with embedded LTE MNPs (0.34 wt.%) were synthesized. Their adhesive and proliferative potential with respect to human dermal fibroblasts were studied. At the same value of Young modulus, the adhesive and proliferative activities of the human dermal fibroblasts on the surface of ferrogel were unexpectedly much higher in comparison with the surface of PAAm gel. Properties of PAAm-100 + γ-Fe2O3 MNPs composites were discussed with focus on creation of a new generation of drug delivery systems combined in multifunctional devices, including magnetic field assisted delivery, positioning, and biosensing. Although exact applications are still under development, the obtained results show a high potential of LTE MNPs to be applied for cellular technologies and tissue engineering. PAAm-100 ferrogel with very low concentration of γ-Fe2O3 MNPs results in significant improvement of the cells’ compatibility to the gel-based scaffold.

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Section: Discussionmentioning

confidence: 99%

The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties

et al. 2019

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“…The multilayered GMI [Ti(6 nm)/Fe 19 Ni 81 (50 nm)] 6 /Ti(6 nm)/Cu(500nm)/Ti(6 nm)/[Fe 19 Ni 81 (50 nm)Ti(6 nm)] 6 elements were deposited by magnetron sputtering onto Corning glass (Corning Incorporated, Corning, NY, USA) substrates, using a background pressure of 3.0 × 10 −7 mbar and Ar working pressure of 3.8 × 10 −3 mbar [13,30]. Fe 19 Ni 81 composition for the magnetic layers was selected taking into account the fact that it insures the lowest magnetostriction, coercivity and high dynamic magnetic permeability [23,31,35,[39][40][41][42]. The thicknesses of permalloy, titanium and copper layers were estimated using information known from previous calibration deposition rate.…”

Section: Methodsmentioning

confidence: 99%

Angular Dependence of the Ferromagnetic Resonance Parameters of [Ti/FeNi]6/Ti/Cu/Ti/[FeNi/Ti]6 Nanostructured Multilayered Elements in the Wide Frequency Range

et al. 2020

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Magnetically soft [Ti(6)/FeNi(50)]6/Ti(6)/Cu(500)/Ti(6)/[FeNi(50)/Ti(6)]6 nanostructured multilayered elements were deposited by rf-sputtering technique in the shape of elongated stripes. The easy magnetization axis was oriented along the short size of the stripe using deposition in the external magnetic field. Such configuration is important for the development of small magnetic field sensors employing giant magnetoimpedance effect (GMI) for different applications. Microwave absorption of electromagnetic radiation was experimentally and theoretically studied in order to provide an as complete as possible high frequency characterization. The conductor-backed coplanar line was used for microwave properties investigation. The medialization for the precession of the magnetization vector in the uniformly magnetized GMI element was done on the basis of the Landau–Lifshitz equation with a dissipative Bloch–Bloembergen term. We applied the method of the complex amplitude for the analysis of the rotation of the ferromagnetic GMI element in the external magnetic field. The calculated and experimental dependences for the amplitudes of the imaginary part of the magnetic susceptibility tensor x-component and magnetoabsorption related to different angles show a good agreement.

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“…Despite limited research on these materials, some researchers used ferrogels as a model material to mimic natural biological tissues, laying the foundation for potentially implantable magnetic biosensors. Buznikov et al(Buznikov et al, 2018) developed a magnetoimpedance (MI) biosensor prototype with a multilayered FeNi/Ni as sensitive element and ferrogels as mimic tissue. Giant magnetoimpedance sensor prototype responses were measured through effective stray field of magnetic nanoparticles and the corresponding model for MI was proposed.…”

Section: Implantable Soft and Flexible Material-based Affinity Sensorsmentioning

confidence: 99%

Soft and flexible material-based affinity sensors

Meng

Turner

Mak

2020

Biotechnology Advances

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Recent advances in biosensors and point-of-care (PoC) devices are poised to change and expand the delivery of diagnostics from conventional lateral-flow assays and test strips that dominate the market currently, to newly emerging wearable and implantable devices that can provide continuous monitoring. Soft and flexible materials are playing a key role in propelling these trends towards real-time and remote health monitoring. Affinity biosensors have the capability to provide for diagnosis and monitoring of cancerous, cardiovascular, infectious and genetic diseases by the detection of biomarkers using affinity interactions. This review tracks the evolution of affinity sensors from conventional lateral-flow assay and test strips to wearable/implantable devices enabled by soft and flexible materials. Initially, we highlight conventional affinity sensors exploiting membrane and paper materials which have been so successfully applied in point-of-care tests, such as lateral-flow immunoassay strips and emerging microfluidic paper-based devices. We then turn our attention to the multifarious polymer designs that provide both the base materials for sensor designs, such as PDMS, and more advanced functionalised materials that are capable of both recognition and transduction, such as conducting and molecularly imprinted polymers. The subsequent content discusses wearable soft and flexible material-based affinity sensors, classified as flexible and skinmountable, textile materials-based and contact lens-based affinity sensors. In the final sections, we explore the possibilities for implantable/injectable soft and flexible affinity sensors, including hydrogels, microencapsulated sensors and optical fibers. This area is truly a work in 2 progress and we trust that this review will help pull together the many technological streams that are contributing to the field.

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Modelling of magnetoimpedance response of thin film sensitive element in the presence of ferrogel: Next step toward development of biosensor for in-tissue embedded magnetic nanoparticles detection

Cited by 64 publications

References 43 publications

The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties

The Contribution of Magnetic Nanoparticles to Ferrogel Biophysical Properties

Angular Dependence of the Ferromagnetic Resonance Parameters of [Ti/FeNi]6/Ti/Cu/Ti/[FeNi/Ti]6 Nanostructured Multilayered Elements in the Wide Frequency Range

Soft and flexible material-based affinity sensors

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