Modelling of endoluminal and interstitial ultrasound hyperthermia and thermal ablation: Applications for device design, feedback control and treatment planning

Prakash, Punit; Salgaonkar, Vasant A.; Diederich, Chris J.

doi:10.3109/02656736.2013.800998

Cited by 27 publications

(21 citation statements)

References 103 publications

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“…Prakash et al [12] review the use of mathematical modelling for endoluminal and interstitial ultrasound hyperthermia and thermal ablation for device design, feedback control and treatment planning. Their main conclusion is that rapid computation techniques should be employed for integrating mathematical modelling in clinical settings.…”

Section: Summary Of This Special Issuementioning

confidence: 99%

The role of mathematical modelling in thermal medicine

Shafirstein

Feng

2013

International Journal of Hyperthermia

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Section: Summary Of This Special Issuementioning

confidence: 99%

The role of mathematical modelling in thermal medicine

Shafirstein

Feng

2013

International Journal of Hyperthermia

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“…From the standpoint of maximizing symmetry, the transducer should be centered and of a cylindrical geometry. This is a design feature in some devices, 22 although there are tradeoffs against the beam width and a resulting decrease in the gain of the transducer. A lower aspect ratio to the transducer's cross section would enhance its symmetry.…”

Section: Discussionmentioning

confidence: 99%

Influence of geometric and material properties on artifacts generated by interventional MRI devices: Relevance to PRF-shift thermometry

et al. 2015

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Purpose: Magnetic resonance imaging (MRI) is capable of providing valuable real-time feedback during medical procedures, partly due to the excellent soft-tissue contrast available. Several technical hurdles still exist to seamless integration of medical devices with MRI due to incompatibility of most conventional devices with this imaging modality. In this study, the effect of local perturbations in the magnetic field caused by the magnetization of medical devices was examined using finite element analysis modeling. As an example, the influence of the geometric and material characteristics of a transurethral high-intensity ultrasound applicator on temperature measurements using proton resonance frequency (PRF)-shift thermometry was investigated. Methods: The effect of local perturbations in the magnetic field, caused by the magnetization of medical device components, was examined using finite element analysis modeling. The thermometry artifact generated by a transurethral ultrasound applicator was simulated, and these results were validated against analytic models and scans of an applicator in a phantom. Several parameters were then varied to identify which most strongly impacted the level of simulated thermometry artifact, which varies as the applicator moves over the course of an ablative high-intensity ultrasound treatment. Results: Key design parameters identified as having a strong influence on the magnitude of thermometry artifact included the susceptibility of materials and their volume. The location of components was also important, particularly when positioned to maximize symmetry of the device. Finally, the location of component edges and the inclination of the device relative to the magnetic field were also found to be important factors. Conclusions: Previous design strategies to minimize thermometry artifact were validated, and novel design strategies were identified that substantially reduce PRF-shift thermometry artifacts for a variety of device orientations. These new strategies are being incorporated into the next generation of applicators. The general strategy described in this study can be applied to the design of other interventional devices intended for use with MRI. C 2016 American Association of Physicists in Medicine. [http://dx.

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“…Although larger transducer surface areas allow for better energy deposition, MIS encourages increasingly smaller probes to reduce incision sizes and dissection requirements—and this tradeoff demands better understanding of acoustic designs to balance both criteria. 13,14,15 In this study, we investigated preliminary focused ultrasound configurations for use in MIS settings, particularly for use in ablation of neuro-oncological lesions. Here, we report the development and in vitro testing of an initial series of probe designs small enough for use in MIS, yet with a large enough transducer surface area to generate the focal point ablations.…”

Section: Introductionmentioning

confidence: 99%

Toward Minimally Invasive Therapeutic Ultrasound: Ultrasound-guided Ablation in Neuro-oncology

Belzberg

Mahapatra

Chavez

et al. 2020

Preprint

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IntroductionTo improve patient outcomes (eg, reducing blood loss and infection), practitioners have gravitated toward noninvasive and minimally invasive surgeries (MIS), which demand specialized toolkits. Focused ultrasound, for example, facilitates thermal ablation from a distance, thereby reducing injury to surrounding tissue. Focused ultrasound can often be performed noninvasively; however, it is more difficult to carry out in neuro-oncological tumors, as ultrasound is dramatically attenuated while propagating through the skull. This shortcoming has prompted exploration of MIS options for intracranial placement of focused ultrasound probes, such as within the BrainPath™ (NICO Corporation, Indianapolis, IN). Herein, we present the design, development, and in vitro testing of an image-guided, focused ultrasound prototype designed for use in MIS procedures. This probe can ablate neuro-oncological lesions despite its small size.Materials & MethodsPreliminary prototypes were iteratively designed, built, and tested. The final prototype consisted of three 8-mm-diameter therapeutic elements guided by an imaging probe. Probe functionality was validated on a series of tissue-mimicking phantoms.ResultsLesions were created in tissue-mimicking phantoms with average dimensions of 2.5×1.2×6.5mm and 3.4×3.25×9.36mm after 10- and 30-second sonification, respectively. 30s sonification with 118W power at 50% duty cycle generated a peak temperature of 68°C. Each ablation was visualized in real time by the built-in imaging probe.ConclusionWe developed and validated an ultrasound-guided focused ultrasound probe for use in MIS procedures. The dimensional constraints of the prototype were designed to reflect those of BrainPath trocars, which are MIS tools used to create atraumatic access to deep-seated brain pathologies.HIGHLIGHTSAn ultrasound-guided, focused ultrasound prototype was developed and validatedThe therapeutic transducer (1.5MHz) consisted of three 8-mm circular elementsElements were placed on a 9×32mm curved rectangular aperture: 45mm radius curvatureFunctionality was examined on tissue-mimicking phantoms2.5×1.2×6.5mm and 3.4×3.25×9.36mm lesions were seen for 10 and 30s sonification

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Modelling of endoluminal and interstitial ultrasound hyperthermia and thermal ablation: Applications for device design, feedback control and treatment planning

Cited by 27 publications

References 103 publications

The role of mathematical modelling in thermal medicine

The role of mathematical modelling in thermal medicine

Influence of geometric and material properties on artifacts generated by interventional MRI devices: Relevance to PRF-shift thermometry

Toward Minimally Invasive Therapeutic Ultrasound: Ultrasound-guided Ablation in Neuro-oncology

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