Modelling of Dynamic Behaviour in Magnetic Nanoparticles

Rietberg, Max Tigo; Waanders, Sebastiaan; Loosdrecht, Melissa Mathilde Horstman-van de; Wildeboer, Rogier R.; Haken, Bennie ten; Alic, Lejla

doi:10.3390/nano11123396

Cited by 9 publications

(5 citation statements)

References 46 publications

(55 reference statements)

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“…These two widely used MNP commercial systems have significant differences in their magnetic properties but both exhibit improved spatial resolution with increasing harmonic number. Although the crystallite diameters for Vivotrax and Synomag are both about 5 nm, Vivotrax shows non-uniform aggregation, but Synomag is a “nanoflower” with well-defined cluster geometry 53 . They exhibit differences in their MPS signatures, AC susceptibility, and PSF widths.…”

Section: Resultsmentioning

confidence: 99%

Harmonic dependence of thermal magnetic particle imaging

Bui,

Henn,

Tew

et al. 2023

Sci Rep

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Advances in instrumentation and tracer materials are still required to enable sensitive, accurate, and localized in situ 3D temperature monitoring by magnetic particle imaging (MPI). We have developed a high-resolution magnetic particle imaging instrument and implemented a low-noise multi-harmonic lock-in detection method to observe and quantify temperature variations in iron oxide nanoparticle tracers using the harmonic ratio method for determining temperature. Using isolated harmonics for MPI and temperature imaging revealed an apparent dependence of imaging resolution on harmonic number. Thus, we present experimental and simulation studies to quantify the imaging resolution dependence on temperature and harmonic number, and directly validate the fundamental origin of MPI imaging resolution on harmonic number based on the concept of a harmonic point-spread-function.

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Section: Resultsmentioning

confidence: 99%

Harmonic dependence of thermal magnetic particle imaging

Bui,

Henn,

Tew

et al. 2023

Sci Rep

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“…Note that figure 4(e) shows that the 3rd harmonic decreases at first and then slightly increases with increasing the excitation frequency. It might be caused by the complex dynamics of the MNPs with coupled Brownian and Neel relaxations [52,53]. We have also measured the MPS signal of Perimag ® Plain MNPs, showing the 3rd harmonic continuously decreases with increasing the excitation frequency (data not provided here).…”

Section: Mps Signal and Dynamic Magnetization Curvementioning

confidence: 86%

A multi-frequency magnetic particle spectroscopy system for systematic characterization and highly sensitive detection of magnetic nanoparticles

Sun,

et al. 2024

Meas. Sci. Technol.

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Systematic characterization and highly sensitive detection of magnetic nanoparticles (MNPs) is of great importance to investigate the magnetic properties of the MNPs for biomedical applications. In this study, a multi-frequency magnetic particle spectroscopy (MPS) system is developed to measure the magnetic response of the MNPs in different ac magnetic fields. A model for the description of the output signal of the MPS system is deduced to analyze the signal-to-noise ratio (SNR) of the MNP harmonics. The noise source, including the Gaussian noise and harmonic distortion from the excitation magnetic field, is quantitatively measured and comprehensively analyzed. Especially, the underlying mechanism of the MNP harmonic SNR dependence on the noise source is investigated. Afterwards, the MPS signal and dynamic magnetization curve of the MNPs are measured in different ac magnetic fields with the developed MPS system. In addition, a series of MNP samples with different iron concentrations are prepared for experiments to determine the limit-of-detection (LOD), indicating an LOD of 2.3 ng in terms of iron. We envisage that the present work is of great importance to systematic characterization and highly sensitive detection of MNPs for magnetic biosensing and magnetic particle imaging.

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“…However, this is quite enough to understand the fundamentals of the magneto-mechanical approach in external MFs, without going further into the analysis of special cases. Detailed cases of restrictions and extensions to other objects were carried out in various works [ 25 , 26 , 27 , 28 ].…”

Section: Theoretical Foundations Of Magneto-mechanical Mnp-assisted P...mentioning

confidence: 99%

Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives

Никитин

Ivanova

Semkina

et al. 2022

IJMS

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The magneto-mechanical approach is a powerful technique used in many different applications in biomedicine, including remote control enzyme activity, cell receptors, cancer-selective treatments, mechanically-activated drug releases, etc. This approach is based on the use of a combination of magnetic nanoparticles and external magnetic fields that have led to the movement of such nanoparticles with torques and forces (enough to change the conformation of biomolecules or even break weak chemical bonds). However, despite many theoretical and experimental works on this topic, it is difficult to predict the magneto-mechanical effects in each particular case, while the important results are scattered and often cannot be translated to other experiments. The main reason is that the magneto-mechanical effect is extremely sensitive to changes in any parameter of magnetic nanoparticles and the environment and changes in the parameters of the applied magnetic field. Thus, in this review, we (1) summarize and propose a simplified theoretical explanation of the main factors affecting the efficiency of the magneto-mechanical approach; (2) discuss the nature of the MNP-mediated mechanical forces and their order of magnitude; (3) show some of the main applications of the magneto-mechanical approach in the control over the properties of biological systems.

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Modelling of Dynamic Behaviour in Magnetic Nanoparticles

Cited by 9 publications

References 46 publications

Harmonic dependence of thermal magnetic particle imaging

Harmonic dependence of thermal magnetic particle imaging

A multi-frequency magnetic particle spectroscopy system for systematic characterization and highly sensitive detection of magnetic nanoparticles

Magneto-Mechanical Approach in Biomedicine: Benefits, Challenges, and Future Perspectives

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