Modelling of AAm-co-alginate hydrogels swelling kinetics

Abstract

In this study, cross-linked acrylamide-co-alginat hydrogels were synthesized by free radical polymerization in aqueous solutions of acrylamide and of acrylamide with sodium alginate as comonomer. For each copolymerization, four different compositions were used and in all systems a concentration of a crosslinker such as oxalic acid and polyethylene glycol dimethacrylate (PEGDMA 500) was employed. As a result of swelling tests, the influence of crosslinkers and the relative content of sodium alginate on the swelling properties in the hydrogels were examined and modeled. Acrylamide-co-alginate hydrogels were swollen in the range 12.72-25.52 g water /g dry gel in water, while acrylamide hydrogels swelled in the range 8.5-10.37 g water /g dry gel. The swelling capacity was found to increase significantly with increase in alginate concentration. The diffusion coefficients (D) of acrylamide-co-alginat hydrogels was calculated in the range 3.39 x 10-10-4.34 x 10-10 m 2 s-1. The experimental swelling data was fitted to three models. The fırst order swelling kınetıc model showed the best fit for all acrylamide-co-alginat hydrogels.

NaAlg-g-AA Hydrogels: Candidates in Sustainable Agriculture Applications

“…This result is also supported by the sol–gel analysis ( Table 2 ). Moreover, some studies have reported that an increase in the degree of swelling is correlated with low values of k 1,s [ 56 , 57 ].…”

In-vitro evaluation of co-excipients for release of donepezil hydrochloride from Carbopol 974P based tablets

“…Among the different drug delivery systems, oral controlled release (CR) formulation is the most preferred in the pharmaceutical industry. [1][2][3] Hydrogels are generally used in matrix tablets in light of their superior characteristics such as flexibility. 4 Oral controlled release systems are one of the most desirable methods due to their low cost and risk of dose dumping and easy manufacturing route.…”